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Hypersensitivity to cutaneous thermal nociceptive stimuli in irritable bowel syndrome.
Pain. 2005 May; 115(1-2):5-11.PAIN

Abstract

Irritable bowel syndrome (IBS) is a common intestinal ailment of which the pathophysiological mechanisms are not well understood. Most IBS patients demonstrate enhanced perception, visceral hypersensitivity, in response to distension of the gut lumen but there are conflicting results about changes in somatic sensitivity. This study focused on the possible contribution of abnormal pain sensitization due to positive feedback (vicious pain cycle) that affects somatic tissues due to viscero-somatic convergence. The specific objectives were to measure cutaneous thermal pain sensitivity along the segmental axis, including in dermatomes that are remote from the visceral pain focus. Pain sensitivity was probed with cutaneous thermal stimulation to the lower and upper extremities and the face in nine diarrhea-predominant IBS patients (diagnosed with ROME II criteria) and 12 healthy female controls. The stimuli were administered with a contact thermode, assuring that size of the stimulated area and stimulus duration were clearly defined and identical in all locations. Sensitization of IBS patients was not limited to symptomatic dermatomes (calf) but extended evenly across the body, including to the face (no sensitization gradient from foot to face). Also, the difference between IBS and control groups did not depend on the evoked pain intensity level, i.e. the degree of sensitization of IBS patients was similar near threshold (10% on the visual analog scale) and at higher intensities. Lastly, no correlation was found between IBS subjects' pain sensitivity of any of the three test sites and their ratings of spontaneous pain.

Authors+Show Affiliations

Department of Neuroscience, University of Florida, P.O. Box 100435, Gainesville, FL 32610-0435, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15836964

Citation

Rodrigues, Anthony C., et al. "Hypersensitivity to Cutaneous Thermal Nociceptive Stimuli in Irritable Bowel Syndrome." Pain, vol. 115, no. 1-2, 2005, pp. 5-11.
Rodrigues AC, Nicholas Verne G, Schmidt S, et al. Hypersensitivity to cutaneous thermal nociceptive stimuli in irritable bowel syndrome. Pain. 2005;115(1-2):5-11.
Rodrigues, A. C., Nicholas Verne, G., Schmidt, S., & Mauderli, A. P. (2005). Hypersensitivity to cutaneous thermal nociceptive stimuli in irritable bowel syndrome. Pain, 115(1-2), 5-11.
Rodrigues AC, et al. Hypersensitivity to Cutaneous Thermal Nociceptive Stimuli in Irritable Bowel Syndrome. Pain. 2005;115(1-2):5-11. PubMed PMID: 15836964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypersensitivity to cutaneous thermal nociceptive stimuli in irritable bowel syndrome. AU - Rodrigues,Anthony C, AU - Nicholas Verne,G, AU - Schmidt,Siegfried, AU - Mauderli,Andre P, PY - 2004/07/16/received PY - 2005/01/28/revised PY - 2005/01/28/accepted PY - 2005/4/20/pubmed PY - 2005/6/29/medline PY - 2005/4/20/entrez SP - 5 EP - 11 JF - Pain JO - Pain VL - 115 IS - 1-2 N2 - Irritable bowel syndrome (IBS) is a common intestinal ailment of which the pathophysiological mechanisms are not well understood. Most IBS patients demonstrate enhanced perception, visceral hypersensitivity, in response to distension of the gut lumen but there are conflicting results about changes in somatic sensitivity. This study focused on the possible contribution of abnormal pain sensitization due to positive feedback (vicious pain cycle) that affects somatic tissues due to viscero-somatic convergence. The specific objectives were to measure cutaneous thermal pain sensitivity along the segmental axis, including in dermatomes that are remote from the visceral pain focus. Pain sensitivity was probed with cutaneous thermal stimulation to the lower and upper extremities and the face in nine diarrhea-predominant IBS patients (diagnosed with ROME II criteria) and 12 healthy female controls. The stimuli were administered with a contact thermode, assuring that size of the stimulated area and stimulus duration were clearly defined and identical in all locations. Sensitization of IBS patients was not limited to symptomatic dermatomes (calf) but extended evenly across the body, including to the face (no sensitization gradient from foot to face). Also, the difference between IBS and control groups did not depend on the evoked pain intensity level, i.e. the degree of sensitization of IBS patients was similar near threshold (10% on the visual analog scale) and at higher intensities. Lastly, no correlation was found between IBS subjects' pain sensitivity of any of the three test sites and their ratings of spontaneous pain. SN - 0304-3959 UR - https://www.unboundmedicine.com/medline/citation/15836964/Hypersensitivity_to_cutaneous_thermal_nociceptive_stimuli_in_irritable_bowel_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3959(05)00042-4 DB - PRIME DP - Unbound Medicine ER -