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Determinants of inducible brain natriuretic peptide promoter activity.
Regul Pept. 2005 Jun 30; 128(3):169-76.RP

Abstract

Atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) are polypeptide hormones belonging to the cardiac-derived mammalian natriuretic peptide system. These hormones share the same biological properties and receptors and both play important roles in the maintenance of fluid and electrolyte balance and in cardiovascular growth. Most hemodynamic and neurohumoral stimuli can coordinately increase ANF and BNP gene expression. However, instances of discoordinated ANF and BNP gene expression have been described, providing an opportunity for investigating the mechanisms that differentially regulate the expression of the natriuretic peptide genes. For example, exposure of cardiocytes in culture to certain pro-inflammatory cytokines and conditioned medium from mixed lymphocyte cultures upregulate BNP but not ANF gene expression. BNP promoter activity is also upregulated under these conditions but the cis-acting elements involved in this phenomenon are not known. In comparison to the ANF gene, less is known about BNP promoter consensus elements that regulate gene expression by mechanical or neurohumoral agonists. A number of cis-acting elements for GATA, Nkx2.5, NF-kappaB and TEF transcription factors have recently been identified within the BNP promoter that regulate BNP expression in response to specific agonists. This review focuses on the information available regarding cis-acting determinants responsible for inducible BNP transcription.

Authors+Show Affiliations

Cardiovascular Endocrinology Laboratory, University of Ottawa Heart Institute, Department of Cellular and Molecular Medicine, Faculty of Medicine, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15837525

Citation

Ma, Kenneth K., et al. "Determinants of Inducible Brain Natriuretic Peptide Promoter Activity." Regulatory Peptides, vol. 128, no. 3, 2005, pp. 169-76.
Ma KK, Banas K, de Bold AJ. Determinants of inducible brain natriuretic peptide promoter activity. Regul Pept. 2005;128(3):169-76.
Ma, K. K., Banas, K., & de Bold, A. J. (2005). Determinants of inducible brain natriuretic peptide promoter activity. Regulatory Peptides, 128(3), 169-76.
Ma KK, Banas K, de Bold AJ. Determinants of Inducible Brain Natriuretic Peptide Promoter Activity. Regul Pept. 2005 Jun 30;128(3):169-76. PubMed PMID: 15837525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determinants of inducible brain natriuretic peptide promoter activity. AU - Ma,Kenneth K, AU - Banas,Krystyna, AU - de Bold,Adolfo J, PY - 2005/4/20/pubmed PY - 2005/9/27/medline PY - 2005/4/20/entrez SP - 169 EP - 76 JF - Regulatory peptides JO - Regul Pept VL - 128 IS - 3 N2 - Atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) are polypeptide hormones belonging to the cardiac-derived mammalian natriuretic peptide system. These hormones share the same biological properties and receptors and both play important roles in the maintenance of fluid and electrolyte balance and in cardiovascular growth. Most hemodynamic and neurohumoral stimuli can coordinately increase ANF and BNP gene expression. However, instances of discoordinated ANF and BNP gene expression have been described, providing an opportunity for investigating the mechanisms that differentially regulate the expression of the natriuretic peptide genes. For example, exposure of cardiocytes in culture to certain pro-inflammatory cytokines and conditioned medium from mixed lymphocyte cultures upregulate BNP but not ANF gene expression. BNP promoter activity is also upregulated under these conditions but the cis-acting elements involved in this phenomenon are not known. In comparison to the ANF gene, less is known about BNP promoter consensus elements that regulate gene expression by mechanical or neurohumoral agonists. A number of cis-acting elements for GATA, Nkx2.5, NF-kappaB and TEF transcription factors have recently been identified within the BNP promoter that regulate BNP expression in response to specific agonists. This review focuses on the information available regarding cis-acting determinants responsible for inducible BNP transcription. SN - 0167-0115 UR - https://www.unboundmedicine.com/medline/citation/15837525/Determinants_of_inducible_brain_natriuretic_peptide_promoter_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-0115(04)00470-7 DB - PRIME DP - Unbound Medicine ER -