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Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men.
Circulation. 2005 Apr 19; 111(15):1904-14.Circ

Abstract

BACKGROUND

The prevalence of cardiovascular disease (CVD) is partly attributable to an inactive and/or overweight population. However, the independent association of body fatness and aerobic fitness with CVD risk factors is uncertain. We sought to determine whether fatness or fitness better predicted traditional CVD risk factors in men with broad fatness, aerobic fitness, and age ranges using 3 expressions of adiposity.

METHODS AND RESULTS

In 135 carefully screened healthy men, we measured 18 established CVD risk factors, body mass index, total percent body fat, waist circumference, and maximal aerobic capacity. Body mass index, percent body fat, and waist circumference were consistently associated with all metabolic risk factors (r=-0.44 to 0.51, P<0.05) after partialling out the effects of aerobic fitness and age. Body mass index and waist circumference were also independently associated with selective hemodynamic risk factors (r=0.20 to 0.30, P< or =0.01). In contrast, aerobic fitness was independently associated with only selective metabolic risk factors (r=-0.21 to 0.19, P<0.05) and was not associated with any hemodynamic risk factors (P>0.05). Both aerobic fitness and body fatness were independently associated with selective hemostatic risk factors (r=-0.22 to -0.26, P< or =0.01; r=-0.32 to 0.48, P<0.05, respectively). Overall, fatness was more strongly and consistently associated with CVD risk factors than aerobic fitness.

CONCLUSIONS

Body fatness is a better predictor of CVD risk factor profile than aerobic fitness in healthy men. Although habitual physical activity is an effective strategy for preventing CVD, elevated body fatness is associated with an adverse CVD risk factor profile independently of aerobic fitness.

Authors+Show Affiliations

Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA. christou@colorado.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15837943

Citation

Christou, Demetra D., et al. "Fatness Is a Better Predictor of Cardiovascular Disease Risk Factor Profile Than Aerobic Fitness in Healthy Men." Circulation, vol. 111, no. 15, 2005, pp. 1904-14.
Christou DD, Gentile CL, DeSouza CA, et al. Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men. Circulation. 2005;111(15):1904-14.
Christou, D. D., Gentile, C. L., DeSouza, C. A., Seals, D. R., & Gates, P. E. (2005). Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men. Circulation, 111(15), 1904-14.
Christou DD, et al. Fatness Is a Better Predictor of Cardiovascular Disease Risk Factor Profile Than Aerobic Fitness in Healthy Men. Circulation. 2005 Apr 19;111(15):1904-14. PubMed PMID: 15837943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men. AU - Christou,Demetra D, AU - Gentile,Christopher L, AU - DeSouza,Christopher A, AU - Seals,Douglas R, AU - Gates,Phillip E, PY - 2005/4/20/pubmed PY - 2005/11/16/medline PY - 2005/4/20/entrez SP - 1904 EP - 14 JF - Circulation JO - Circulation VL - 111 IS - 15 N2 - BACKGROUND: The prevalence of cardiovascular disease (CVD) is partly attributable to an inactive and/or overweight population. However, the independent association of body fatness and aerobic fitness with CVD risk factors is uncertain. We sought to determine whether fatness or fitness better predicted traditional CVD risk factors in men with broad fatness, aerobic fitness, and age ranges using 3 expressions of adiposity. METHODS AND RESULTS: In 135 carefully screened healthy men, we measured 18 established CVD risk factors, body mass index, total percent body fat, waist circumference, and maximal aerobic capacity. Body mass index, percent body fat, and waist circumference were consistently associated with all metabolic risk factors (r=-0.44 to 0.51, P<0.05) after partialling out the effects of aerobic fitness and age. Body mass index and waist circumference were also independently associated with selective hemodynamic risk factors (r=0.20 to 0.30, P< or =0.01). In contrast, aerobic fitness was independently associated with only selective metabolic risk factors (r=-0.21 to 0.19, P<0.05) and was not associated with any hemodynamic risk factors (P>0.05). Both aerobic fitness and body fatness were independently associated with selective hemostatic risk factors (r=-0.22 to -0.26, P< or =0.01; r=-0.32 to 0.48, P<0.05, respectively). Overall, fatness was more strongly and consistently associated with CVD risk factors than aerobic fitness. CONCLUSIONS: Body fatness is a better predictor of CVD risk factor profile than aerobic fitness in healthy men. Although habitual physical activity is an effective strategy for preventing CVD, elevated body fatness is associated with an adverse CVD risk factor profile independently of aerobic fitness. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/15837943/Fatness_is_a_better_predictor_of_cardiovascular_disease_risk_factor_profile_than_aerobic_fitness_in_healthy_men_ L2 - https://www.ahajournals.org/doi/10.1161/01.CIR.0000161818.28974.1A?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -