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Results of a search for the mechanisms of steroid receptor regulation of gene expression.
Ann N Y Acad Sci. 2004 Dec; 1038:80-7.AN

Abstract

This publication provides a brief summary of a presentation given at the NICHD Anniversary Symposium that was designed to describe the research progress of the O'Malley laboratory over the past 30 years of its NICHD funding. It highlights a few of the lab's major discoveries during the course of the pursuit of its long-standing goal to define the molecular pathway for steroid hormone action. The key discovery that set the scientific tone for the lab over the ensuing few decades began with the discovery that steroid hormones induced the nuclear production of specific mRNAs for ovalbumin and avidin in the chick oviduct. This completed the pathway from receptor to specific proteins and indicated that steroid receptors were transcription factors. More recently the lab discovered the first coactivators (e.g., SRC-1) for steroid hormone receptors and has subsequently elucidated the many and diverse roles of nuclear coactivators in transcription reactions and in cell signaling.

Authors+Show Affiliations

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. berto@bcm.tmc.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15838100

Citation

O'Malley, Bert W.. "Results of a Search for the Mechanisms of Steroid Receptor Regulation of Gene Expression." Annals of the New York Academy of Sciences, vol. 1038, 2004, pp. 80-7.
O'Malley BW. Results of a search for the mechanisms of steroid receptor regulation of gene expression. Ann N Y Acad Sci. 2004;1038:80-7.
O'Malley, B. W. (2004). Results of a search for the mechanisms of steroid receptor regulation of gene expression. Annals of the New York Academy of Sciences, 1038, 80-7.
O'Malley BW. Results of a Search for the Mechanisms of Steroid Receptor Regulation of Gene Expression. Ann N Y Acad Sci. 2004;1038:80-7. PubMed PMID: 15838100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Results of a search for the mechanisms of steroid receptor regulation of gene expression. A1 - O'Malley,Bert W, PY - 2005/4/20/pubmed PY - 2005/11/10/medline PY - 2005/4/20/entrez SP - 80 EP - 7 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1038 N2 - This publication provides a brief summary of a presentation given at the NICHD Anniversary Symposium that was designed to describe the research progress of the O'Malley laboratory over the past 30 years of its NICHD funding. It highlights a few of the lab's major discoveries during the course of the pursuit of its long-standing goal to define the molecular pathway for steroid hormone action. The key discovery that set the scientific tone for the lab over the ensuing few decades began with the discovery that steroid hormones induced the nuclear production of specific mRNAs for ovalbumin and avidin in the chick oviduct. This completed the pathway from receptor to specific proteins and indicated that steroid receptors were transcription factors. More recently the lab discovered the first coactivators (e.g., SRC-1) for steroid hormone receptors and has subsequently elucidated the many and diverse roles of nuclear coactivators in transcription reactions and in cell signaling. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/15838100/Results_of_a_search_for_the_mechanisms_of_steroid_receptor_regulation_of_gene_expression_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=2004&volume=1038&spage=80 DB - PRIME DP - Unbound Medicine ER -