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Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature.
Br J Dermatol. 2005 Apr; 152(4):780-3.BJ

Abstract

Cutaneous drug reactions occur with a frequency of 1-8% and can be higher for certain classes of drugs. They can range from mild morbilliform eruptions to more severe forms such as drug-hypersensitivity syndrome, toxic epidermal necrolysis or anaphylaxis. Acute generalized exanthematous pustulosis (AGEP) is considered to be a clinical reaction pattern, which is induced in over 90% of the cases by systemic drugs. It is a rare presentation of an adverse drug reaction most frequently triggered by anti-infectious drugs. A high proportion of these cases have been attributed to aminopenicillins and macrolides. We report a terbinafine-induced AGEP in a 68-year-old male confirmed by lymphocyte stimulation in vitro, and review the published cases induced by antimycotic drugs with special emphasis on terbinafine-triggered cases.

Authors+Show Affiliations

Beltraminelli HS
Department of Dermatology, Kantonsspital Basel, University of Basel, Petersgraben 4 CH-4031 Basel, Switzerland. hbeltraminelli@uhbs.ch
Lerch M
No affiliation info available
Arnold A
No affiliation info available
Bircher AJ
No affiliation info available
Haeusermann P
No affiliation info available

MeSH

AgedAntifungal AgentsExanthemaHumansLymphocyte ActivationMaleNaphthalenesOnychomycosisSkin Diseases, VesiculobullousTerbinafine

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

15840114

Citation

Beltraminelli, H S., et al. "Acute Generalized Exanthematous Pustulosis Induced By the Antifungal Terbinafine: Case Report and Review of the Literature." The British Journal of Dermatology, vol. 152, no. 4, 2005, pp. 780-3.
Beltraminelli HS, Lerch M, Arnold A, et al. Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature. Br J Dermatol. 2005;152(4):780-3.
Beltraminelli, H. S., Lerch, M., Arnold, A., Bircher, A. J., & Haeusermann, P. (2005). Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature. The British Journal of Dermatology, 152(4), 780-3.
Beltraminelli HS, et al. Acute Generalized Exanthematous Pustulosis Induced By the Antifungal Terbinafine: Case Report and Review of the Literature. Br J Dermatol. 2005;152(4):780-3. PubMed PMID: 15840114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature. AU - Beltraminelli,H S, AU - Lerch,M, AU - Arnold,A, AU - Bircher,A J, AU - Haeusermann,P, PY - 2005/4/21/pubmed PY - 2005/7/15/medline PY - 2005/4/21/entrez SP - 780 EP - 3 JF - The British journal of dermatology JO - Br J Dermatol VL - 152 IS - 4 N2 - Cutaneous drug reactions occur with a frequency of 1-8% and can be higher for certain classes of drugs. They can range from mild morbilliform eruptions to more severe forms such as drug-hypersensitivity syndrome, toxic epidermal necrolysis or anaphylaxis. Acute generalized exanthematous pustulosis (AGEP) is considered to be a clinical reaction pattern, which is induced in over 90% of the cases by systemic drugs. It is a rare presentation of an adverse drug reaction most frequently triggered by anti-infectious drugs. A high proportion of these cases have been attributed to aminopenicillins and macrolides. We report a terbinafine-induced AGEP in a 68-year-old male confirmed by lymphocyte stimulation in vitro, and review the published cases induced by antimycotic drugs with special emphasis on terbinafine-triggered cases. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/15840114/Acute_generalized_exanthematous_pustulosis_induced_by_the_antifungal_terbinafine:_case_report_and_review_of_the_literature_ DB - PRIME DP - Unbound Medicine ER -