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Extended blockade of the discriminative stimulus effects of nicotine with low doses of ethanol.
Eur J Pharmacol. 2005 Apr 11; 512(2-3):165-72.EJ

Abstract

The aim of the present study was to further evaluate effects of ethanol on nicotine discrimination and to correlate these effects with blood ethanol levels. Rats were trained to discriminate 0.3 mg/kg nicotine from its vehicle in the standard two-lever operant procedure. In antagonism tests, small doses of ethanol (0.25-0.5 g/kg) were injected either 5 or 50 min before nicotine. Both doses of ethanol partially antagonized the nicotine cue regardless of the pre-treatment time. Ethanol attenuated also inhibitory effects of nicotine on the rate of responding. Suppression of the cueing effects of nicotine was noted even 60 min after the injection of 0.25 g/kg ethanol, i.e. at the time point when the blood ethanol level was close to zero. Ethanol-induced antagonism of the nicotine cue disappeared when longer time (110 min) was allowed to elapse between the ethanol (0.5 g/kg) and nicotine injection. Concluding, the present results may indicate that the effects of ethanol on nicotine discrimination are not primarily related to blood ethanol levels.

Authors+Show Affiliations

Department of Pharmacology, Institute of Psychiatry and Neurology, 9 Sobieskiego St., PL-02957, Warsaw, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15840401

Citation

Korkosz, Agnieszka, et al. "Extended Blockade of the Discriminative Stimulus Effects of Nicotine With Low Doses of Ethanol." European Journal of Pharmacology, vol. 512, no. 2-3, 2005, pp. 165-72.
Korkosz A, Taracha E, Plaznik A, et al. Extended blockade of the discriminative stimulus effects of nicotine with low doses of ethanol. Eur J Pharmacol. 2005;512(2-3):165-72.
Korkosz, A., Taracha, E., Plaznik, A., Wrobel, E., Kostowski, W., & Bienkowski, P. (2005). Extended blockade of the discriminative stimulus effects of nicotine with low doses of ethanol. European Journal of Pharmacology, 512(2-3), 165-72.
Korkosz A, et al. Extended Blockade of the Discriminative Stimulus Effects of Nicotine With Low Doses of Ethanol. Eur J Pharmacol. 2005 Apr 11;512(2-3):165-72. PubMed PMID: 15840401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extended blockade of the discriminative stimulus effects of nicotine with low doses of ethanol. AU - Korkosz,Agnieszka, AU - Taracha,Ewa, AU - Plaznik,Adam, AU - Wrobel,Elzbieta, AU - Kostowski,Wojciech, AU - Bienkowski,Przemyslaw, PY - 2005/02/08/received PY - 2005/02/18/accepted PY - 2005/4/21/pubmed PY - 2005/8/6/medline PY - 2005/4/21/entrez SP - 165 EP - 72 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 512 IS - 2-3 N2 - The aim of the present study was to further evaluate effects of ethanol on nicotine discrimination and to correlate these effects with blood ethanol levels. Rats were trained to discriminate 0.3 mg/kg nicotine from its vehicle in the standard two-lever operant procedure. In antagonism tests, small doses of ethanol (0.25-0.5 g/kg) were injected either 5 or 50 min before nicotine. Both doses of ethanol partially antagonized the nicotine cue regardless of the pre-treatment time. Ethanol attenuated also inhibitory effects of nicotine on the rate of responding. Suppression of the cueing effects of nicotine was noted even 60 min after the injection of 0.25 g/kg ethanol, i.e. at the time point when the blood ethanol level was close to zero. Ethanol-induced antagonism of the nicotine cue disappeared when longer time (110 min) was allowed to elapse between the ethanol (0.5 g/kg) and nicotine injection. Concluding, the present results may indicate that the effects of ethanol on nicotine discrimination are not primarily related to blood ethanol levels. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/15840401/Extended_blockade_of_the_discriminative_stimulus_effects_of_nicotine_with_low_doses_of_ethanol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(05)00185-8 DB - PRIME DP - Unbound Medicine ER -