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The prevalence of the metabolic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population.

Abstract

CONTEXT

Diabetes and obesity, components of the metabolic syndrome, are common characteristics of women with prior gestational diabetes mellitus (GDM). Due to increasing incidence of diabetes and obesity, the metabolic syndrome might comprise a major health problem among these women.

OBJECTIVE

The objective was to estimate the prevalence of the metabolic syndrome by three different criteria [World Health Organization 1999 (WHO), The National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults 2001, and European Group for the Study of Insulin Resistance 2002] among women with previous GDM.

DESIGN

We conducted a follow-up study of a Danish cohort of women admitted in 1978-1996 to the Diabetes and Pregnancy Center, Rigshospitalet, Copenhagen University Hospital, with diet-treated GDM. The follow-up took place in 2000-2002 at median 9.8 yr (interquartile range 6.4-17.2) after pregnancy. Results were compared with a control group of 1000 age-matched women from a population-based sample (Inter99).

PARTICIPANTS

Four hundred eighty-one women at median age 43 yr (interquartile range 38-48) participated.

MAIN OUTCOME MEASURES

The main outcome measures were body mass index (BMI), glucose tolerance, blood pressure, lipid profile, and insulin resistance.

RESULTS

Independent of the criteria, the prevalence of the metabolic syndrome was three times higher in the prior GDM group, compared with the control group (e.g. WHO: 38.4 vs. 13.4%, P < 0.0005). Age- and BMI-adjusted odds ratio for having the WHO-defined metabolic syndrome was 3.4 (95% confidence interval 2.5-4.8) for the prior GDM group vs. the control group. Obese women (BMI > 30 kg/m(2)) with previous GDM had a more than 7-fold increased prevalence of the metabolic syndrome (WHO), compared with normal-weight prior GDM women (BMI < 25 kg/m(2)). In glucose-tolerant women, the prevalence was doubled in the prior GDM group, compared with control group.

CONCLUSION

The prevalence of the metabolic syndrome was three times as high in women with prior diet-treated GDM, compared with age-matched control subjects.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Obstetrics, 4031, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. jeannet@lauenb.org.

    , , , , , , ,

    Source

    MeSH

    Adult
    Diabetes, Gestational
    Female
    Humans
    Metabolic Syndrome
    Middle Aged
    Pregnancy
    Prevalence

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15840755

    Citation

    Lauenborg, Jeannet, et al. "The Prevalence of the Metabolic Syndrome in a Danish Population of Women With Previous Gestational Diabetes Mellitus Is Three-fold Higher Than in the General Population." The Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 7, 2005, pp. 4004-10.
    Lauenborg J, Mathiesen E, Hansen T, et al. The prevalence of the metabolic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population. J Clin Endocrinol Metab. 2005;90(7):4004-10.
    Lauenborg, J., Mathiesen, E., Hansen, T., Glümer, C., Jørgensen, T., Borch-Johnsen, K., ... Damm, P. (2005). The prevalence of the metabolic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population. The Journal of Clinical Endocrinology and Metabolism, 90(7), pp. 4004-10.
    Lauenborg J, et al. The Prevalence of the Metabolic Syndrome in a Danish Population of Women With Previous Gestational Diabetes Mellitus Is Three-fold Higher Than in the General Population. J Clin Endocrinol Metab. 2005;90(7):4004-10. PubMed PMID: 15840755.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The prevalence of the metabolic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population. AU - Lauenborg,Jeannet, AU - Mathiesen,Elisabeth, AU - Hansen,Torben, AU - Glümer,Charlotte, AU - Jørgensen,Torben, AU - Borch-Johnsen,Knut, AU - Hornnes,Peter, AU - Pedersen,Oluf, AU - Damm,Peter, Y1 - 2005/04/19/ PY - 2005/4/21/pubmed PY - 2005/8/10/medline PY - 2005/4/21/entrez SP - 4004 EP - 10 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 90 IS - 7 N2 - CONTEXT: Diabetes and obesity, components of the metabolic syndrome, are common characteristics of women with prior gestational diabetes mellitus (GDM). Due to increasing incidence of diabetes and obesity, the metabolic syndrome might comprise a major health problem among these women. OBJECTIVE: The objective was to estimate the prevalence of the metabolic syndrome by three different criteria [World Health Organization 1999 (WHO), The National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults 2001, and European Group for the Study of Insulin Resistance 2002] among women with previous GDM. DESIGN: We conducted a follow-up study of a Danish cohort of women admitted in 1978-1996 to the Diabetes and Pregnancy Center, Rigshospitalet, Copenhagen University Hospital, with diet-treated GDM. The follow-up took place in 2000-2002 at median 9.8 yr (interquartile range 6.4-17.2) after pregnancy. Results were compared with a control group of 1000 age-matched women from a population-based sample (Inter99). PARTICIPANTS: Four hundred eighty-one women at median age 43 yr (interquartile range 38-48) participated. MAIN OUTCOME MEASURES: The main outcome measures were body mass index (BMI), glucose tolerance, blood pressure, lipid profile, and insulin resistance. RESULTS: Independent of the criteria, the prevalence of the metabolic syndrome was three times higher in the prior GDM group, compared with the control group (e.g. WHO: 38.4 vs. 13.4%, P < 0.0005). Age- and BMI-adjusted odds ratio for having the WHO-defined metabolic syndrome was 3.4 (95% confidence interval 2.5-4.8) for the prior GDM group vs. the control group. Obese women (BMI > 30 kg/m(2)) with previous GDM had a more than 7-fold increased prevalence of the metabolic syndrome (WHO), compared with normal-weight prior GDM women (BMI < 25 kg/m(2)). In glucose-tolerant women, the prevalence was doubled in the prior GDM group, compared with control group. CONCLUSION: The prevalence of the metabolic syndrome was three times as high in women with prior diet-treated GDM, compared with age-matched control subjects. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/15840755/The_prevalence_of_the_metabolic_syndrome_in_a_danish_population_of_women_with_previous_gestational_diabetes_mellitus_is_three_fold_higher_than_in_the_general_population_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2004-1713 DB - PRIME DP - Unbound Medicine ER -