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[Diabetes and depression].
Dtsch Med Wochenschr. 2005 Apr 29; 130(17):1097-102.DM

Abstract

Cohort studies indicate a high prevalence of depression in patients with diabetes mellitus. Despite numerous investigations, the underlying pathophysiologies of the metabolic abnormalities are poorly understood. A possible role play the increased counter-regulatory hormone release involved in glucose homeostasis, alterations in the glucose transport function and increased inflammatory activation triggered by depression. The diagnose of "depression" in diabetic patients might be hampered by similar symptoms of both conditions as fatigue, psychomotor inhibition, reduced appetite or sexual dysfunction. In treating depressive patients with diabetes one should consider potential induction or worsening of diabetes-like metabolic alterations. Selective serotonin-reuptake-inhibitors, venlafaxin and MAO-Inhibitors constitute a beneficial choice. Atypical antipsychotics like clozapine, olanzapine, quetiapine and risperidone should be given with precaution due to potential effects on glucose homeostasis.

Authors+Show Affiliations

Klinik und Hochschulambulanz für Psychiatrie und Psychotherapie, Charité -- Universitätsmedizin Berlin. francesca.regen@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

15841425

Citation

Regen, F, et al. "[Diabetes and Depression]." Deutsche Medizinische Wochenschrift (1946), vol. 130, no. 17, 2005, pp. 1097-102.
Regen F, Merkl A, Heuser I, et al. [Diabetes and depression]. Dtsch Med Wochenschr. 2005;130(17):1097-102.
Regen, F., Merkl, A., Heuser, I., Dettling, M., & Anghelescu, I. (2005). [Diabetes and depression]. Deutsche Medizinische Wochenschrift (1946), 130(17), 1097-102.
Regen F, et al. [Diabetes and Depression]. Dtsch Med Wochenschr. 2005 Apr 29;130(17):1097-102. PubMed PMID: 15841425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diabetes and depression]. AU - Regen,F, AU - Merkl,A, AU - Heuser,I, AU - Dettling,M, AU - Anghelescu,I, PY - 2005/4/21/pubmed PY - 2005/5/25/medline PY - 2005/4/21/entrez SP - 1097 EP - 102 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch. Med. Wochenschr. VL - 130 IS - 17 N2 - Cohort studies indicate a high prevalence of depression in patients with diabetes mellitus. Despite numerous investigations, the underlying pathophysiologies of the metabolic abnormalities are poorly understood. A possible role play the increased counter-regulatory hormone release involved in glucose homeostasis, alterations in the glucose transport function and increased inflammatory activation triggered by depression. The diagnose of "depression" in diabetic patients might be hampered by similar symptoms of both conditions as fatigue, psychomotor inhibition, reduced appetite or sexual dysfunction. In treating depressive patients with diabetes one should consider potential induction or worsening of diabetes-like metabolic alterations. Selective serotonin-reuptake-inhibitors, venlafaxin and MAO-Inhibitors constitute a beneficial choice. Atypical antipsychotics like clozapine, olanzapine, quetiapine and risperidone should be given with precaution due to potential effects on glucose homeostasis. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/15841425/[Diabetes_and_depression]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2005-866794 DB - PRIME DP - Unbound Medicine ER -