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Placental pathology and pregnancy outcomes in donor and non-donor oocyte in vitro fertilization pregnancies.
J Perinat Med. 2005; 33(1):27-32.JP

Abstract

OBJECTIVE

Intrinsically poor maternal adaptation to pregnancy and dysregulated processes have been postulated to occur as a consequence of an immune response to the feto-placental unit as "foreign" material. The aim of our study was to compare placental pathology and pregnancy outcomes of in vitro fertilization (IVF) pregnancies conceived by donor oocytes with those conceived by non-donor oocytes.

STUDY DESIGN

We conducted a retrospective, case-control study on 91 placentas from IVF pregnancies (36 from donor oocytes and 55 from non-donor cycles). All placentas were examined by a single pathologist for signs indicative of an immune response, including chronic villitis, chronic deciduitis, increased perivillous fibrin, ischemic change/infarction, decidual vasculopathy, increased syncytial knots, intervillous thrombi, and retroplacental hematomas.

RESULTS

Placentas from donor cycles were significantly more likely to demonstrate certain pathologic findings: chronic villitis (P<0.001), chronic deciduitis (P=0.034), increased perivillous fibrin (P=0.001), ischemic change/ infarction (P=0.001), and intervillous thrombi (P =0.008). There was no statistical significance with respect to decidual vasculopathy, increased syncytial knots, or retroplacental hematomas.

CONCLUSION

Pathologic evidence of an immune-mediated process is much more pronounced in donor oocyte IVF pregnancies compared to non-donor cycles. Clinical implications of these findings have yet to be determined.

Authors+Show Affiliations

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA. scperni@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15841610

Citation

Perni, Sriram C., et al. "Placental Pathology and Pregnancy Outcomes in Donor and Non-donor Oocyte in Vitro Fertilization Pregnancies." Journal of Perinatal Medicine, vol. 33, no. 1, 2005, pp. 27-32.
Perni SC, Predanic M, Predanik M, et al. Placental pathology and pregnancy outcomes in donor and non-donor oocyte in vitro fertilization pregnancies. J Perinat Med. 2005;33(1):27-32.
Perni, S. C., Predanic, M., Predanik, M., Cho, J. E., & Baergen, R. N. (2005). Placental pathology and pregnancy outcomes in donor and non-donor oocyte in vitro fertilization pregnancies. Journal of Perinatal Medicine, 33(1), 27-32.
Perni SC, et al. Placental Pathology and Pregnancy Outcomes in Donor and Non-donor Oocyte in Vitro Fertilization Pregnancies. J Perinat Med. 2005;33(1):27-32. PubMed PMID: 15841610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placental pathology and pregnancy outcomes in donor and non-donor oocyte in vitro fertilization pregnancies. AU - Perni,Sriram C, AU - Predanic,Mladen, AU - Predanik,Mladen, AU - Cho,Jennifer E, AU - Baergen,Rebecca N, PY - 2005/4/22/pubmed PY - 2005/5/20/medline PY - 2005/4/22/entrez SP - 27 EP - 32 JF - Journal of perinatal medicine JO - J Perinat Med VL - 33 IS - 1 N2 - OBJECTIVE: Intrinsically poor maternal adaptation to pregnancy and dysregulated processes have been postulated to occur as a consequence of an immune response to the feto-placental unit as "foreign" material. The aim of our study was to compare placental pathology and pregnancy outcomes of in vitro fertilization (IVF) pregnancies conceived by donor oocytes with those conceived by non-donor oocytes. STUDY DESIGN: We conducted a retrospective, case-control study on 91 placentas from IVF pregnancies (36 from donor oocytes and 55 from non-donor cycles). All placentas were examined by a single pathologist for signs indicative of an immune response, including chronic villitis, chronic deciduitis, increased perivillous fibrin, ischemic change/infarction, decidual vasculopathy, increased syncytial knots, intervillous thrombi, and retroplacental hematomas. RESULTS: Placentas from donor cycles were significantly more likely to demonstrate certain pathologic findings: chronic villitis (P<0.001), chronic deciduitis (P=0.034), increased perivillous fibrin (P=0.001), ischemic change/ infarction (P=0.001), and intervillous thrombi (P =0.008). There was no statistical significance with respect to decidual vasculopathy, increased syncytial knots, or retroplacental hematomas. CONCLUSION: Pathologic evidence of an immune-mediated process is much more pronounced in donor oocyte IVF pregnancies compared to non-donor cycles. Clinical implications of these findings have yet to be determined. SN - 0300-5577 UR - https://www.unboundmedicine.com/medline/citation/15841610/Placental_pathology_and_pregnancy_outcomes_in_donor_and_non_donor_oocyte_in_vitro_fertilization_pregnancies_ L2 - https://www.degruyter.com/doi/10.1515/JPM.2005.004 DB - PRIME DP - Unbound Medicine ER -