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Neuropathology of Parkinson's disease and related syndromes.
Neurol Clin. 1992 May; 10(2):361-76.NC

Abstract

A progressive parkinsonian disorder predicts pathology in the substantia nigra and possibly elsewhere in the basal ganglia. Parkinson's disease is a manifestation of Lewy body disease, which is characterized by the association between Lewy bodies and cell degeneration in specific neuronal populations. Striatonigral degeneration is part of multiple system atrophy and is characterized by striatal and nigral degeneration without neuronal inclusion bodies, but glial inclusions have been described. Steele-Richardson-Olszewski disease is characterized by the globose neurofibrillary tangle and predominant brain stem pathology. Corticobasal degeneration shows similar midbrain pathology and a round, filamentous inclusion in the substantia nigra, not unlike the globose tangle, but there is also focal frontoparietal cortical atrophy. The combination of the distribution of degeneration and nerve cell morphology identify apparently distinct disorders, but most of the neuronal inclusions are not disease specific.

Authors+Show Affiliations

University Department of Neurology, King's College School of Medicine and Dentistry, London, United Kingdom.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1584179

Citation

Gibb, W R.. "Neuropathology of Parkinson's Disease and Related Syndromes." Neurologic Clinics, vol. 10, no. 2, 1992, pp. 361-76.
Gibb WR. Neuropathology of Parkinson's disease and related syndromes. Neurol Clin. 1992;10(2):361-76.
Gibb, W. R. (1992). Neuropathology of Parkinson's disease and related syndromes. Neurologic Clinics, 10(2), 361-76.
Gibb WR. Neuropathology of Parkinson's Disease and Related Syndromes. Neurol Clin. 1992;10(2):361-76. PubMed PMID: 1584179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropathology of Parkinson's disease and related syndromes. A1 - Gibb,W R, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 361 EP - 76 JF - Neurologic clinics JO - Neurol Clin VL - 10 IS - 2 N2 - A progressive parkinsonian disorder predicts pathology in the substantia nigra and possibly elsewhere in the basal ganglia. Parkinson's disease is a manifestation of Lewy body disease, which is characterized by the association between Lewy bodies and cell degeneration in specific neuronal populations. Striatonigral degeneration is part of multiple system atrophy and is characterized by striatal and nigral degeneration without neuronal inclusion bodies, but glial inclusions have been described. Steele-Richardson-Olszewski disease is characterized by the globose neurofibrillary tangle and predominant brain stem pathology. Corticobasal degeneration shows similar midbrain pathology and a round, filamentous inclusion in the substantia nigra, not unlike the globose tangle, but there is also focal frontoparietal cortical atrophy. The combination of the distribution of degeneration and nerve cell morphology identify apparently distinct disorders, but most of the neuronal inclusions are not disease specific. SN - 0733-8619 UR - https://www.unboundmedicine.com/medline/citation/1584179/Neuropathology_of_Parkinson's_disease_and_related_syndromes_ L2 - https://www.diseaseinfosearch.org/result/5603 DB - PRIME DP - Unbound Medicine ER -