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Antifungal activity of Ocimum gratissimum towards dermatophytes.
Mycoses. 2005 May; 48(3):172-5.M

Abstract

The development of more effective and less toxic antifungal agents is required for the treatment of dermatophytosis. Plants and their preparations have been used as medicines against infectious diseases. Extracts of Ocimum gratissimum leaves were investigated for in vitro antifungal activity, using agar dilution technique against dermatophytes. The extracts (hexane, chloroform fractions, the essential oil and eugenol) produced antifungal activities against Microsporum canis, M. gypseum, Trichophyton rubrum and T. mentagrophytes. Trichophyton rubrum, the most common aetiological agent of dermatophytosis in Goiânia, state of Goiás, Brazil, was also the most susceptible dermatophyte. The hexane fraction and eugenol were the most active. Hexane fraction inhibited the growth of 100% of dermatophytes at a concentration of 125 microg ml(-1), while eugenol inhibited the growth of 80% of dermatophytes at this same concentration. These results show that extracts of O. gratissimum are active in vitro against human pathogenic dermatophytes.

Authors+Show Affiliations

Silva MR
Instituto de Patologia Tropical e Saúde Pública da UFG, Goiânia, Goiás, Brazil. rosario@iptsp.ufg.br
Oliveira JG
No affiliation info available
Fernandes OF
No affiliation info available
Passos XS
No affiliation info available
Costa CR
No affiliation info available
Souza LK
No affiliation info available
Lemos JA
No affiliation info available
Paula JR
No affiliation info available

MeSH

Antifungal AgentsArthrodermataceaeBrazilMicrobial Sensitivity TestsMicrosporumOcimumPlant ExtractsPlant LeavesTrichophyton

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15842332

Citation

Silva, M R R., et al. "Antifungal Activity of Ocimum Gratissimum Towards Dermatophytes." Mycoses, vol. 48, no. 3, 2005, pp. 172-5.
Silva MR, Oliveira JG, Fernandes OF, et al. Antifungal activity of Ocimum gratissimum towards dermatophytes. Mycoses. 2005;48(3):172-5.
Silva, M. R., Oliveira, J. G., Fernandes, O. F., Passos, X. S., Costa, C. R., Souza, L. K., Lemos, J. A., & Paula, J. R. (2005). Antifungal activity of Ocimum gratissimum towards dermatophytes. Mycoses, 48(3), 172-5.
Silva MR, et al. Antifungal Activity of Ocimum Gratissimum Towards Dermatophytes. Mycoses. 2005;48(3):172-5. PubMed PMID: 15842332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal activity of Ocimum gratissimum towards dermatophytes. AU - Silva,M R R, AU - Oliveira,J G,Jr AU - Fernandes,O F L, AU - Passos,X S, AU - Costa,C R, AU - Souza,L K H, AU - Lemos,J A, AU - Paula,J R, PY - 2005/4/22/pubmed PY - 2005/6/23/medline PY - 2005/4/22/entrez SP - 172 EP - 5 JF - Mycoses JO - Mycoses VL - 48 IS - 3 N2 - The development of more effective and less toxic antifungal agents is required for the treatment of dermatophytosis. Plants and their preparations have been used as medicines against infectious diseases. Extracts of Ocimum gratissimum leaves were investigated for in vitro antifungal activity, using agar dilution technique against dermatophytes. The extracts (hexane, chloroform fractions, the essential oil and eugenol) produced antifungal activities against Microsporum canis, M. gypseum, Trichophyton rubrum and T. mentagrophytes. Trichophyton rubrum, the most common aetiological agent of dermatophytosis in Goiânia, state of Goiás, Brazil, was also the most susceptible dermatophyte. The hexane fraction and eugenol were the most active. Hexane fraction inhibited the growth of 100% of dermatophytes at a concentration of 125 microg ml(-1), while eugenol inhibited the growth of 80% of dermatophytes at this same concentration. These results show that extracts of O. gratissimum are active in vitro against human pathogenic dermatophytes. SN - 0933-7407 UR - https://www.unboundmedicine.com/medline/citation/15842332/Antifungal_activity_of_Ocimum_gratissimum_towards_dermatophytes_ DB - PRIME DP - Unbound Medicine ER -