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Factors associated with the presence of nonalcoholic steatohepatitis in patients with chronic hepatitis C.
Am J Gastroenterol 2005; 100(5):1091-8AJ

Abstract

OBJECTIVES

The aim of this study was to identify factors associated with the presence of nonalcoholic steatohepatitis (NASH) in patients with chronic hepatitis C (CHC).

METHODS

We studied 98 patients with CHC [47 with NASH (group HCV/NASH), 51 without NASH (group HCV)] and 85 with NASH not infected with hepatitis C virus (HCV) (group NASH). We determined factors associated with the presence of NASH in patients with hepatitis C.

RESULTS

Group HCV/NASH patients resembled those with NASH. Body mass index (BMI) was higher in group HCV/NASH than in group HCV, but was similar to group NASH. Most HCV/NASH patients had risk factors for NASH. In patients infected with HCV, NASH and NASH-related lesions were independently associated with BMI, while steatosis score was associated with HCV genotype 3 and BMI. Fibrosis stage was independently associated with steatosis, necroinflammatory activity index, and NASH lesions.

CONCLUSION

While HCV genotype 3 infection and BMI are associated with the presence of steatosis in CHC, BMI is the only factor independently associated with the presence of NASH in these patients. We suggest that overweight-related factors might induce NASH in CHC patients.

Authors+Show Affiliations

Departments of Gastroenterology and Pathology, Hospital Universitario Doce de Octubre, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15842583

Citation

Solis-Herruzo, José A., et al. "Factors Associated With the Presence of Nonalcoholic Steatohepatitis in Patients With Chronic Hepatitis C." The American Journal of Gastroenterology, vol. 100, no. 5, 2005, pp. 1091-8.
Solis-Herruzo JA, Pérez-Carreras M, Rivas E, et al. Factors associated with the presence of nonalcoholic steatohepatitis in patients with chronic hepatitis C. Am J Gastroenterol. 2005;100(5):1091-8.
Solis-Herruzo, J. A., Pérez-Carreras, M., Rivas, E., Fernández-Vázquez, I., Garfia, C., Bernardos, E., ... Colina, F. (2005). Factors associated with the presence of nonalcoholic steatohepatitis in patients with chronic hepatitis C. The American Journal of Gastroenterology, 100(5), pp. 1091-8.
Solis-Herruzo JA, et al. Factors Associated With the Presence of Nonalcoholic Steatohepatitis in Patients With Chronic Hepatitis C. Am J Gastroenterol. 2005;100(5):1091-8. PubMed PMID: 15842583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with the presence of nonalcoholic steatohepatitis in patients with chronic hepatitis C. AU - Solis-Herruzo,José A, AU - Pérez-Carreras,Mercedes, AU - Rivas,Eloy, AU - Fernández-Vázquez,Inmaculada, AU - Garfia,Cristina, AU - Bernardos,Esther, AU - Castellano,Gregorio, AU - Colina,Francisco, PY - 2005/4/22/pubmed PY - 2005/6/2/medline PY - 2005/4/22/entrez SP - 1091 EP - 8 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 100 IS - 5 N2 - OBJECTIVES: The aim of this study was to identify factors associated with the presence of nonalcoholic steatohepatitis (NASH) in patients with chronic hepatitis C (CHC). METHODS: We studied 98 patients with CHC [47 with NASH (group HCV/NASH), 51 without NASH (group HCV)] and 85 with NASH not infected with hepatitis C virus (HCV) (group NASH). We determined factors associated with the presence of NASH in patients with hepatitis C. RESULTS: Group HCV/NASH patients resembled those with NASH. Body mass index (BMI) was higher in group HCV/NASH than in group HCV, but was similar to group NASH. Most HCV/NASH patients had risk factors for NASH. In patients infected with HCV, NASH and NASH-related lesions were independently associated with BMI, while steatosis score was associated with HCV genotype 3 and BMI. Fibrosis stage was independently associated with steatosis, necroinflammatory activity index, and NASH lesions. CONCLUSION: While HCV genotype 3 infection and BMI are associated with the presence of steatosis in CHC, BMI is the only factor independently associated with the presence of NASH in these patients. We suggest that overweight-related factors might induce NASH in CHC patients. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/15842583/Factors_associated_with_the_presence_of_nonalcoholic_steatohepatitis_in_patients_with_chronic_hepatitis_C_ L2 - http://Insights.ovid.com/pubmed?pmid=15842583 DB - PRIME DP - Unbound Medicine ER -