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Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels.
Am J Gastroenterol 2005; 100(5):1154-60AJ

Abstract

OBJECTIVES

Acromegalics have been reported to be at an increased risk of colorectal neoplasm. However, the magnitude of the risk is still controversial and the mechanism has not been fully investigated. In this study, we attempted to determine the magnitude of the association between acromegaly and colorectal lesions after taking into account age, gender, smoking status, and treatment status. In addition, we assessed the relationship between colorectal lesions and serum growth hormone (GH) levels in acromegalics.

METHODS

We conducted a case-control study by using 19 consecutive untreated patients (male:female = 11:8) who were newly diagnosed with acromegaly between 1990 and 2000. All patients underwent colonoscopy and received a histological diagnosis of colorectal lesions. Prevalence of hyperplastic polyp, adenoma, and carcinoma were compared with the prevalence in 76 controls matched for gender, age, and smoking status. Serum GH levels were compared between acromegalic patients with and without each type of colorectal lesion.

RESULTS

The prevalence of hyperplastic polyp, adenoma, and carcinoma were significantly higher in the acromegalic patients compared to the controls (p < 0.05, odds ratios; 8.3, 4.2, and 9.8, respectively). In acromegalics, the presence of hyperplastic polyps and carcinomas were significantly associated with higher serum GH levels after adjusting for the other lesions and age (p < 0.05).

CONCLUSIONS

After controlling for age, gender, smoking status, and treatment status, acromegaly was associated with significantly higher prevalence of colorectal hyperplastic polyp, adenoma, and carcinoma. High serum GH levels may be associated with the presence of hyperplastic polyp and carcinoma.

Authors+Show Affiliations

The Second Department of Internal Medicine, Kanazawa University School of Medicine, Ishikawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15842593

Citation

Matano, Yutaka, et al. "Risk of Colorectal Neoplasm in Patients With Acromegaly and Its Relationship With Serum Growth Hormone Levels." The American Journal of Gastroenterology, vol. 100, no. 5, 2005, pp. 1154-60.
Matano Y, Okada T, Suzuki A, et al. Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels. Am J Gastroenterol. 2005;100(5):1154-60.
Matano, Y., Okada, T., Suzuki, A., Yoneda, T., Takeda, Y., & Mabuchi, H. (2005). Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels. The American Journal of Gastroenterology, 100(5), pp. 1154-60.
Matano Y, et al. Risk of Colorectal Neoplasm in Patients With Acromegaly and Its Relationship With Serum Growth Hormone Levels. Am J Gastroenterol. 2005;100(5):1154-60. PubMed PMID: 15842593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels. AU - Matano,Yutaka, AU - Okada,Toshihide, AU - Suzuki,Ayako, AU - Yoneda,Takashi, AU - Takeda,Yoshiyun, AU - Mabuchi,Hiroshi, PY - 2005/4/22/pubmed PY - 2005/6/2/medline PY - 2005/4/22/entrez SP - 1154 EP - 60 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 100 IS - 5 N2 - OBJECTIVES: Acromegalics have been reported to be at an increased risk of colorectal neoplasm. However, the magnitude of the risk is still controversial and the mechanism has not been fully investigated. In this study, we attempted to determine the magnitude of the association between acromegaly and colorectal lesions after taking into account age, gender, smoking status, and treatment status. In addition, we assessed the relationship between colorectal lesions and serum growth hormone (GH) levels in acromegalics. METHODS: We conducted a case-control study by using 19 consecutive untreated patients (male:female = 11:8) who were newly diagnosed with acromegaly between 1990 and 2000. All patients underwent colonoscopy and received a histological diagnosis of colorectal lesions. Prevalence of hyperplastic polyp, adenoma, and carcinoma were compared with the prevalence in 76 controls matched for gender, age, and smoking status. Serum GH levels were compared between acromegalic patients with and without each type of colorectal lesion. RESULTS: The prevalence of hyperplastic polyp, adenoma, and carcinoma were significantly higher in the acromegalic patients compared to the controls (p < 0.05, odds ratios; 8.3, 4.2, and 9.8, respectively). In acromegalics, the presence of hyperplastic polyps and carcinomas were significantly associated with higher serum GH levels after adjusting for the other lesions and age (p < 0.05). CONCLUSIONS: After controlling for age, gender, smoking status, and treatment status, acromegaly was associated with significantly higher prevalence of colorectal hyperplastic polyp, adenoma, and carcinoma. High serum GH levels may be associated with the presence of hyperplastic polyp and carcinoma. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/15842593/Risk_of_colorectal_neoplasm_in_patients_with_acromegaly_and_its_relationship_with_serum_growth_hormone_levels_ L2 - http://Insights.ovid.com/pubmed?pmid=15842593 DB - PRIME DP - Unbound Medicine ER -