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Usefulness of enalapril versus propranolol or atenolol for prevention of aortic dilation in patients with the Marfan syndrome.
Am J Cardiol. 2005 May 01; 95(9):1125-7.AJ

Abstract

Despite variable clinical results, beta blockers have become the primary therapy for prevention of aortic dilation in patients with the Marfan syndrome. This study examines the use of the angiotensin-converting enzyme inhibitor enalapril for treatment of these patients. We sought to examine the effects of enalapril versus beta-blocker therapy in patients with the Marfan syndrome and noted improved aortic distensibility (3.0 +/- 0.3 vs 1.9 +/- 0.4 cm2 dynes(-1); p <0.02) and a reduced aortic stiffness index (8.0 +/- 2.9 vs 18.4 +/- 3.8; p <0.05) in patients receiving enalapril compared with those receiving beta blockers. These favorable hemodynamic changes were associated with a smaller increase in aortic root diameter (0.1 +/- 1.0 vs 5.8 +/- 5.2 mm) and fewer clinical end points during follow-up.

Authors+Show Affiliations

Yetman AT
Division of Cardiology, Department of Pediatrics, The Children's Hospital, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA. Yetman.Angela@tchden.org
Bornemeier RA
No affiliation info available
McCrindle BW
No affiliation info available

MeSH

AdolescentAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsAortaAtenololChildDilatation, PathologicEnalaprilFemaleHumansMaleMarfan SyndromePropranololProspective StudiesTreatment Outcome

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15842990

Citation

Yetman, Anji T., et al. "Usefulness of Enalapril Versus Propranolol or Atenolol for Prevention of Aortic Dilation in Patients With the Marfan Syndrome." The American Journal of Cardiology, vol. 95, no. 9, 2005, pp. 1125-7.
Yetman AT, Bornemeier RA, McCrindle BW. Usefulness of enalapril versus propranolol or atenolol for prevention of aortic dilation in patients with the Marfan syndrome. Am J Cardiol. 2005;95(9):1125-7.
Yetman, A. T., Bornemeier, R. A., & McCrindle, B. W. (2005). Usefulness of enalapril versus propranolol or atenolol for prevention of aortic dilation in patients with the Marfan syndrome. The American Journal of Cardiology, 95(9), 1125-7.
Yetman AT, Bornemeier RA, McCrindle BW. Usefulness of Enalapril Versus Propranolol or Atenolol for Prevention of Aortic Dilation in Patients With the Marfan Syndrome. Am J Cardiol. 2005 May 1;95(9):1125-7. PubMed PMID: 15842990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of enalapril versus propranolol or atenolol for prevention of aortic dilation in patients with the Marfan syndrome. AU - Yetman,Anji T, AU - Bornemeier,Renee A, AU - McCrindle,Brian W, PY - 2004/09/24/received PY - 2005/01/05/revised PY - 2005/01/04/accepted PY - 2005/4/22/pubmed PY - 2005/6/18/medline PY - 2005/4/22/entrez SP - 1125 EP - 7 JF - The American journal of cardiology JO - Am J Cardiol VL - 95 IS - 9 N2 - Despite variable clinical results, beta blockers have become the primary therapy for prevention of aortic dilation in patients with the Marfan syndrome. This study examines the use of the angiotensin-converting enzyme inhibitor enalapril for treatment of these patients. We sought to examine the effects of enalapril versus beta-blocker therapy in patients with the Marfan syndrome and noted improved aortic distensibility (3.0 +/- 0.3 vs 1.9 +/- 0.4 cm2 dynes(-1); p <0.02) and a reduced aortic stiffness index (8.0 +/- 2.9 vs 18.4 +/- 3.8; p <0.05) in patients receiving enalapril compared with those receiving beta blockers. These favorable hemodynamic changes were associated with a smaller increase in aortic root diameter (0.1 +/- 1.0 vs 5.8 +/- 5.2 mm) and fewer clinical end points during follow-up. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/15842990/Usefulness_of_enalapril_versus_propranolol_or_atenolol_for_prevention_of_aortic_dilation_in_patients_with_the_Marfan_syndrome_ DB - PRIME DP - Unbound Medicine ER -