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Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy.
Brain. 2005 Jun; 128(Pt 6):1259-66.B

Abstract

Most cerebral imaging studies of patients with progressive supranuclear palsy (PSP) have noted subtle atrophy, although the full extent of atrophy and any correlates to clinical features have not been determined. We used voxel-based morphometry analysis of grey matter, white matter and CSF on MRI brain scans to map the statistical probability of regional tissue atrophy in 21 patients with PSP, 17 patients with Parkinson's disease and 23 controls. PSP and Parkinson's disease cohorts were selected to approximate the mid-stages of their respective disease courses. Where regions of significant tissue atrophy were identified in a disease group relative to controls, the probability of tissue loss within those regions was correlated with global indices of motor disability, and behavioural and cognitive disturbance for that disease group. Minimal regional atrophy was observed in Parkinson's disease. PSP could be distinguished from both controls and Parkinson's disease by symmetrical tissue loss in the frontal cortex (maximal in the orbitofrontal and medial frontal cortices), subcortical nuclei (midbrain, caudate and thalamic) as well as periventricular white matter. For PSP, motor deficits correlated with atrophy of the caudate and motor cingulate, while behavioural changes related to atrophy in the orbitofrontal cortex and midbrain. These data suggest that intrinsic neurodegeneration of specific subcortical nuclei and frontal cortical subregions together contribute to motor and behavioural disturbances in PSP and differentiate this disorder from Parkinson's disease within 2-4 years of symptom onset.

Authors+Show Affiliations

Department of Geriatric Medicine, Westmead Hospital and the University of Sydney, Westmead, NSW, Australia. Nicholas_Cordato@wsahs.nsw.gov.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15843423

Citation

Cordato, N J., et al. "Clinical Deficits Correlate With Regional Cerebral Atrophy in Progressive Supranuclear Palsy." Brain : a Journal of Neurology, vol. 128, no. Pt 6, 2005, pp. 1259-66.
Cordato NJ, Duggins AJ, Halliday GM, et al. Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy. Brain. 2005;128(Pt 6):1259-66.
Cordato, N. J., Duggins, A. J., Halliday, G. M., Morris, J. G., & Pantelis, C. (2005). Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy. Brain : a Journal of Neurology, 128(Pt 6), 1259-66.
Cordato NJ, et al. Clinical Deficits Correlate With Regional Cerebral Atrophy in Progressive Supranuclear Palsy. Brain. 2005;128(Pt 6):1259-66. PubMed PMID: 15843423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy. AU - Cordato,N J, AU - Duggins,A J, AU - Halliday,G M, AU - Morris,J G L, AU - Pantelis,C, Y1 - 2005/04/20/ PY - 2005/4/22/pubmed PY - 2005/9/15/medline PY - 2005/4/22/entrez SP - 1259 EP - 66 JF - Brain : a journal of neurology JO - Brain VL - 128 IS - Pt 6 N2 - Most cerebral imaging studies of patients with progressive supranuclear palsy (PSP) have noted subtle atrophy, although the full extent of atrophy and any correlates to clinical features have not been determined. We used voxel-based morphometry analysis of grey matter, white matter and CSF on MRI brain scans to map the statistical probability of regional tissue atrophy in 21 patients with PSP, 17 patients with Parkinson's disease and 23 controls. PSP and Parkinson's disease cohorts were selected to approximate the mid-stages of their respective disease courses. Where regions of significant tissue atrophy were identified in a disease group relative to controls, the probability of tissue loss within those regions was correlated with global indices of motor disability, and behavioural and cognitive disturbance for that disease group. Minimal regional atrophy was observed in Parkinson's disease. PSP could be distinguished from both controls and Parkinson's disease by symmetrical tissue loss in the frontal cortex (maximal in the orbitofrontal and medial frontal cortices), subcortical nuclei (midbrain, caudate and thalamic) as well as periventricular white matter. For PSP, motor deficits correlated with atrophy of the caudate and motor cingulate, while behavioural changes related to atrophy in the orbitofrontal cortex and midbrain. These data suggest that intrinsic neurodegeneration of specific subcortical nuclei and frontal cortical subregions together contribute to motor and behavioural disturbances in PSP and differentiate this disorder from Parkinson's disease within 2-4 years of symptom onset. SN - 1460-2156 UR - https://www.unboundmedicine.com/medline/citation/15843423/Clinical_deficits_correlate_with_regional_cerebral_atrophy_in_progressive_supranuclear_palsy_ L2 - https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awh508 DB - PRIME DP - Unbound Medicine ER -