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Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein Barr virus encoded latent membrane protein 1.
Sci China C Life Sci. 2005 Feb; 48(1):70-80.SC

Abstract

Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) may trigger the transcription factor AP-1 including c-Jun and c-fos. In this report, using a Tet-on LMP1 HNE2 cell line which is a dual-stable LMP1 integrated nasopharyngeal carcinoma (NPC) cell line and the expression of LMP1 in which could be regulated by the Tet-on system, we show that Jun B can efficiently form a new heterodimeric complex with the c-Jun protein under the regulation of LMP1, phosphorylation of c-Jun (ser 63, ser 73) and Jun B is involved in the process of the new heterodimeric formation. We also find that this heterodimeric form can bind to the AP-1 consensus sequence. Transfection studies suggest that JNK interaction protein (JIP) could inhibit the heterodimer formation of c-Jun and Jun B through blocking the AP-1 signaling pathway triggered by LMP1. The interaction and function between c-Jun protein and Jun B protein increase the repertoire of possible regulatory complexes by LMP1 that could play an important role in the regulation of transcription of specific cellular genes in the process of genesis of nasopharyngeal carcinoma.

Authors+Show Affiliations

Cancer Research Institute, Xiangya School of Medicine, Central South of University, Changsha 410078, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15844359

Citation

Song, Xin, et al. "Heterodimer Formation Between c-Jun and Jun B Proteins Mediated By Epstein Barr Virus Encoded Latent Membrane Protein 1." Science in China. Series C, Life Sciences, vol. 48, no. 1, 2005, pp. 70-80.
Song X, Tao Y, Tan Y, et al. Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein Barr virus encoded latent membrane protein 1. Sci China C Life Sci. 2005;48(1):70-80.
Song, X., Tao, Y., Tan, Y., Lee, L. M., Deng, X., Wu, Q., & Cao, Y. (2005). Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein Barr virus encoded latent membrane protein 1. Science in China. Series C, Life Sciences, 48(1), 70-80.
Song X, et al. Heterodimer Formation Between c-Jun and Jun B Proteins Mediated By Epstein Barr Virus Encoded Latent Membrane Protein 1. Sci China C Life Sci. 2005;48(1):70-80. PubMed PMID: 15844359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein Barr virus encoded latent membrane protein 1. AU - Song,Xin, AU - Tao,Yongguang, AU - Tan,Yunnian, AU - Lee,Leo M, AU - Deng,Xiyun, AU - Wu,Qiao, AU - Cao,Ya, PY - 2005/4/23/pubmed PY - 2005/7/19/medline PY - 2005/4/23/entrez SP - 70 EP - 80 JF - Science in China. Series C, Life sciences JO - Sci China C Life Sci VL - 48 IS - 1 N2 - Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) may trigger the transcription factor AP-1 including c-Jun and c-fos. In this report, using a Tet-on LMP1 HNE2 cell line which is a dual-stable LMP1 integrated nasopharyngeal carcinoma (NPC) cell line and the expression of LMP1 in which could be regulated by the Tet-on system, we show that Jun B can efficiently form a new heterodimeric complex with the c-Jun protein under the regulation of LMP1, phosphorylation of c-Jun (ser 63, ser 73) and Jun B is involved in the process of the new heterodimeric formation. We also find that this heterodimeric form can bind to the AP-1 consensus sequence. Transfection studies suggest that JNK interaction protein (JIP) could inhibit the heterodimer formation of c-Jun and Jun B through blocking the AP-1 signaling pathway triggered by LMP1. The interaction and function between c-Jun protein and Jun B protein increase the repertoire of possible regulatory complexes by LMP1 that could play an important role in the regulation of transcription of specific cellular genes in the process of genesis of nasopharyngeal carcinoma. SN - 1006-9305 UR - https://www.unboundmedicine.com/medline/citation/15844359/Heterodimer_formation_between_c_Jun_and_Jun_B_proteins_mediated_by_Epstein_Barr_virus_encoded_latent_membrane_protein_1_ L2 - https://antibodies.cancer.gov/detail/CPTC-OTUB1-1 DB - PRIME DP - Unbound Medicine ER -