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Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes.
Am J Obstet Gynecol. 2005 Apr; 192(4):1162-6.AJ

Abstract

OBJECTIVE

To compare morbidities of neonates born to women who developed chorioamnionitis after premature preterm rupture of membranes versus those who did not.

STUDY DESIGN

We reviewed outcomes in singleton pregnancies with confirmed premature preterm rupture of membranes at 24 weeks or beyond that resulted in delivery less than 37 weeks. Management of premature preterm rupture of membranes included the use of antibiotics, betamethasone if less than 32 weeks, and expectant management with induction at 34 weeks or greater. Composite neonatal major and minor morbidity rates were compared between pregnancies complicated by chorioamnionitis and those that were not.

RESULTS

From August 1998 to August 2000, 430 cases of premature preterm rupture of membranes were identified among 6003 deliveries (7.2%). Thirteen percent of women (56/430) with premature preterm rupture of membranes developed chorioamnionitis. The incidence of chorioamnionitis increased significantly with decreasing gestational age. The composite neonatal major morbidity rate was significantly higher in neonates whose mothers developed chorioamnionitis (55%) versus those who did not (18%, P < .0001). In a multiple logistic regression model, chorioamnionitis (P < .0001), infant gender (P = .007), latency (P = .03), and gestational age at delivery (P < .0001) were significantly associated with composite neonatal morbidity.

CONCLUSION

Neonatal morbidities are significantly higher among pregnancies with premature preterm rupture of membranes complicated by chorioamnionitis when compared with pregnancies that were not.

Authors+Show Affiliations

Division of Maternal-Fetal Medicine, Department of Obstetrics/Gynecology, 458 Old Hillman Building, 619 19th St South, Birmingham, AL, USA. ramsey_patrick@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15846196

Citation

Ramsey, Patrick S., et al. "Chorioamnionitis Increases Neonatal Morbidity in Pregnancies Complicated By Preterm Premature Rupture of Membranes." American Journal of Obstetrics and Gynecology, vol. 192, no. 4, 2005, pp. 1162-6.
Ramsey PS, Lieman JM, Brumfield CG, et al. Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes. Am J Obstet Gynecol. 2005;192(4):1162-6.
Ramsey, P. S., Lieman, J. M., Brumfield, C. G., & Carlo, W. (2005). Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes. American Journal of Obstetrics and Gynecology, 192(4), 1162-6.
Ramsey PS, et al. Chorioamnionitis Increases Neonatal Morbidity in Pregnancies Complicated By Preterm Premature Rupture of Membranes. Am J Obstet Gynecol. 2005;192(4):1162-6. PubMed PMID: 15846196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes. AU - Ramsey,Patrick S, AU - Lieman,Joelle M, AU - Brumfield,Cynthia G, AU - Carlo,Waldemar, PY - 2005/4/23/pubmed PY - 2005/5/25/medline PY - 2005/4/23/entrez SP - 1162 EP - 6 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 192 IS - 4 N2 - OBJECTIVE: To compare morbidities of neonates born to women who developed chorioamnionitis after premature preterm rupture of membranes versus those who did not. STUDY DESIGN: We reviewed outcomes in singleton pregnancies with confirmed premature preterm rupture of membranes at 24 weeks or beyond that resulted in delivery less than 37 weeks. Management of premature preterm rupture of membranes included the use of antibiotics, betamethasone if less than 32 weeks, and expectant management with induction at 34 weeks or greater. Composite neonatal major and minor morbidity rates were compared between pregnancies complicated by chorioamnionitis and those that were not. RESULTS: From August 1998 to August 2000, 430 cases of premature preterm rupture of membranes were identified among 6003 deliveries (7.2%). Thirteen percent of women (56/430) with premature preterm rupture of membranes developed chorioamnionitis. The incidence of chorioamnionitis increased significantly with decreasing gestational age. The composite neonatal major morbidity rate was significantly higher in neonates whose mothers developed chorioamnionitis (55%) versus those who did not (18%, P < .0001). In a multiple logistic regression model, chorioamnionitis (P < .0001), infant gender (P = .007), latency (P = .03), and gestational age at delivery (P < .0001) were significantly associated with composite neonatal morbidity. CONCLUSION: Neonatal morbidities are significantly higher among pregnancies with premature preterm rupture of membranes complicated by chorioamnionitis when compared with pregnancies that were not. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/15846196/Chorioamnionitis_increases_neonatal_morbidity_in_pregnancies_complicated_by_preterm_premature_rupture_of_membranes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937804019933 DB - PRIME DP - Unbound Medicine ER -