Tags

Type your tag names separated by a space and hit enter

Effect of SBE7-beta-cyclodextrin complexation on carbamazepine release from sustained release beads.
Eur J Pharm Biopharm. 2005 May; 60(1):73-80.EJ

Abstract

The effect of SBE7-beta-cyclodextrin together with hydroxypropylmethyl cellulose (HPMC) or polyvinylpyrrolidone (PVP) on the saturated solubility and delivery of carbamazepine (a poorly soluble drug) from sustained release (SR) beads was investigated. Carbamazepine solubility at room temperature increased from 0.1 to 5.4mg/ml by forming an inclusion complex with SBE7-beta-cyclodextrin (15%w/v). HPMC (0.1%w/v) also increased the aqueous solubility of carbamazepine, acting both alone and synergistically with SBE7-beta-cyclodextrin, to produce solubility values of 0.26 and 8.1mg/ml respectively. PVP (0.1-0.5%w/v) had no effect on carbamazepine solubility, either alone or in combination with SBE7-beta-cyclodextrin. The addition of SBE7-beta-cyclodextrin to SR beads increased the rate of carbamazepine release. In addition, comparable release rates where obtained when lower ratios of SBE7-beta-cyclodextrin together HPMC were incorporated in the SR bead. Therefore this ternary drug cyclodextrin polymer system was considered preferable over the binary drug cyclodextrin system for SR beads, as less cyclodextrin was required. However, both binary and ternary approaches were considered suitable techniques to improve the release rate and potentially the in vivo bioavailability of poorly soluble drugs that had previously exhibited slow or incomplete release from SR beads.

Authors+Show Affiliations

Pharmaceutical Research and Development, Pfizer Global Research and Development, Sandwich, UK. janet.s.smith@pfizer.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15848059

Citation

Smith, J S., et al. "Effect of SBE7-beta-cyclodextrin Complexation On Carbamazepine Release From Sustained Release Beads." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 60, no. 1, 2005, pp. 73-80.
Smith JS, Macrae RJ, Snowden MJ. Effect of SBE7-beta-cyclodextrin complexation on carbamazepine release from sustained release beads. Eur J Pharm Biopharm. 2005;60(1):73-80.
Smith, J. S., Macrae, R. J., & Snowden, M. J. (2005). Effect of SBE7-beta-cyclodextrin complexation on carbamazepine release from sustained release beads. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 60(1), 73-80.
Smith JS, Macrae RJ, Snowden MJ. Effect of SBE7-beta-cyclodextrin Complexation On Carbamazepine Release From Sustained Release Beads. Eur J Pharm Biopharm. 2005;60(1):73-80. PubMed PMID: 15848059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of SBE7-beta-cyclodextrin complexation on carbamazepine release from sustained release beads. AU - Smith,J S, AU - Macrae,R J, AU - Snowden,M J, PY - 2004/03/11/received PY - 2004/12/01/revised PY - 2004/12/07/accepted PY - 2005/4/26/pubmed PY - 2005/9/24/medline PY - 2005/4/26/entrez SP - 73 EP - 80 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 60 IS - 1 N2 - The effect of SBE7-beta-cyclodextrin together with hydroxypropylmethyl cellulose (HPMC) or polyvinylpyrrolidone (PVP) on the saturated solubility and delivery of carbamazepine (a poorly soluble drug) from sustained release (SR) beads was investigated. Carbamazepine solubility at room temperature increased from 0.1 to 5.4mg/ml by forming an inclusion complex with SBE7-beta-cyclodextrin (15%w/v). HPMC (0.1%w/v) also increased the aqueous solubility of carbamazepine, acting both alone and synergistically with SBE7-beta-cyclodextrin, to produce solubility values of 0.26 and 8.1mg/ml respectively. PVP (0.1-0.5%w/v) had no effect on carbamazepine solubility, either alone or in combination with SBE7-beta-cyclodextrin. The addition of SBE7-beta-cyclodextrin to SR beads increased the rate of carbamazepine release. In addition, comparable release rates where obtained when lower ratios of SBE7-beta-cyclodextrin together HPMC were incorporated in the SR bead. Therefore this ternary drug cyclodextrin polymer system was considered preferable over the binary drug cyclodextrin system for SR beads, as less cyclodextrin was required. However, both binary and ternary approaches were considered suitable techniques to improve the release rate and potentially the in vivo bioavailability of poorly soluble drugs that had previously exhibited slow or incomplete release from SR beads. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/15848059/Effect_of_SBE7_beta_cyclodextrin_complexation_on_carbamazepine_release_from_sustained_release_beads_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(04)00323-6 DB - PRIME DP - Unbound Medicine ER -