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Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats.
Life Sci. 2005 May 20; 77(1):1-14.LS

Abstract

Intracerebroventricular (ICV) injection of streptozotocin (STZ) causes cognitive impairment in rats. ICV STZ is known to impair cholinergic neurotransmission by decreasing choline acetyltransferase (ChAT) levels, glucose and energy metabolism in brain and synthesis of acetyl CoA. However, no reports are available regarding the cholinesterase inhibitors in this model. In aging brain, reduced energy metabolism increases glutamate release, which is blocked by L-type calcium channel blockers. These calcium channel blockers have shown beneficial effects on learning and memory in various models of cognitive impairment. The present study was designed to investigate the influence of chronic administration of donepezil (cholinesterase inhibitor, 1 and 3 mg/kg) and lercanidipine (L-type calcium channel blocker, 0.3 and 1 mg/kg) on cognitive impairment in male Sprague-Dawley rats injected twice with ICV STZ (3 mg/kg) bilaterally on days 1 and 3. ICV STZ injected rats developed a severe deficit in learning and memory indicated by deficits in passive avoidance paradigm and elevated plus maze as compared to control rats. Cholinesterase activity in brain was significantly increased in ICV STZ injected rats. Donepezil dose-dependently inhibited cholinesterase activity and improved performance in memory tests at both the doses. Lercanidipine (0.3 mg/kg) showed significant improvement in memory. When administered together, the effect of combination of these two drugs on memory and cholinesterase activity was higher than that obtained with either of the drugs when used alone.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar 160062, Punjab, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15848214

Citation

Sonkusare, Swapnil, et al. "Effect of Donepezil and Lercanidipine On Memory Impairment Induced By Intracerebroventricular Streptozotocin in Rats." Life Sciences, vol. 77, no. 1, 2005, pp. 1-14.
Sonkusare S, Srinivasan K, Kaul C, et al. Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats. Life Sci. 2005;77(1):1-14.
Sonkusare, S., Srinivasan, K., Kaul, C., & Ramarao, P. (2005). Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats. Life Sciences, 77(1), 1-14.
Sonkusare S, et al. Effect of Donepezil and Lercanidipine On Memory Impairment Induced By Intracerebroventricular Streptozotocin in Rats. Life Sci. 2005 May 20;77(1):1-14. PubMed PMID: 15848214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats. AU - Sonkusare,Swapnil, AU - Srinivasan,Krishnamoorthy, AU - Kaul,Chamanlal, AU - Ramarao,Poduri, PY - 2004/03/09/received PY - 2004/10/23/accepted PY - 2005/4/26/pubmed PY - 2005/6/15/medline PY - 2005/4/26/entrez SP - 1 EP - 14 JF - Life sciences JO - Life Sci VL - 77 IS - 1 N2 - Intracerebroventricular (ICV) injection of streptozotocin (STZ) causes cognitive impairment in rats. ICV STZ is known to impair cholinergic neurotransmission by decreasing choline acetyltransferase (ChAT) levels, glucose and energy metabolism in brain and synthesis of acetyl CoA. However, no reports are available regarding the cholinesterase inhibitors in this model. In aging brain, reduced energy metabolism increases glutamate release, which is blocked by L-type calcium channel blockers. These calcium channel blockers have shown beneficial effects on learning and memory in various models of cognitive impairment. The present study was designed to investigate the influence of chronic administration of donepezil (cholinesterase inhibitor, 1 and 3 mg/kg) and lercanidipine (L-type calcium channel blocker, 0.3 and 1 mg/kg) on cognitive impairment in male Sprague-Dawley rats injected twice with ICV STZ (3 mg/kg) bilaterally on days 1 and 3. ICV STZ injected rats developed a severe deficit in learning and memory indicated by deficits in passive avoidance paradigm and elevated plus maze as compared to control rats. Cholinesterase activity in brain was significantly increased in ICV STZ injected rats. Donepezil dose-dependently inhibited cholinesterase activity and improved performance in memory tests at both the doses. Lercanidipine (0.3 mg/kg) showed significant improvement in memory. When administered together, the effect of combination of these two drugs on memory and cholinesterase activity was higher than that obtained with either of the drugs when used alone. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/15848214/Effect_of_donepezil_and_lercanidipine_on_memory_impairment_induced_by_intracerebroventricular_streptozotocin_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(05)00019-6 DB - PRIME DP - Unbound Medicine ER -