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Pharmacokinetics of an ampicillin-sulbactam combination after intravenous and intramuscular administration to neonatal calves.
Vet J. 2005 May; 169(3):437-43.VJ

Abstract

The pharmacokinetics of a 2:1 ampicillin-sulbactam combination after intravenous (i.v.) and intramuscular (i.m.) injection at a single dose rate of 20 mg/kg bodyweight (13.33 mg/kg of sodium ampicillin and 6.67 mg/kg of sodium sulbactam) were studied in 10-day-old neonatal calves (n = 10). The plasma concentration-time data of both antibiotics were best fitted to an open two-compartment model after i.v. administration. After i.m. administration, an open two-compartment model demonstrated first order absorption. The apparent volumes of distribution of ampicillin and sulbactam, calculated by the area method, were 0.20+/-0.01 and 0.18+/-0.01 L/kg, respectively, and the total body clearances were 0.51+/-0.03 and 0.21+/-0.01 L/kg h. The elimination half-lives of ampicillin after i.v. and i.m. administration were 0.99+/-0.03 and 1.01+/-0.02 h, respectively, whereas for sulbactam the half-lives were 2.24+/-0.02 and 3.44+/-0.94 h. The bioavailability after i.m. injection was high and similar for both drugs (70.31+/-0.2% for ampicillin and 68.62+/-4.44% for sulbactam). The mean peak plasma concentrations of ampicillin and sulbactam were reached at similar times (0.47+/-0.02 and 0.72+/-0.01 h, respectively) and peak concentrations were also similar but not proportional to the dose administered (17.88+/-0.91 mg/L of ampicillin and 12.92+/-0.79 mg/L of sulbactam). Both drugs had similar pharmacokinetic behaviour after i.m. administration. Since the plasma concentrations of sulbactam were consistently higher during the elimination phase of their disposition, consideration could be given to formulating the ampicillin-sulbactam combination in a ratio higher than 2:1.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30.071 Murcia, Spain. emiliofv@um.esNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15848786

Citation

Fernández-Varón, Emilio, et al. "Pharmacokinetics of an Ampicillin-sulbactam Combination After Intravenous and Intramuscular Administration to Neonatal Calves." Veterinary Journal (London, England : 1997), vol. 169, no. 3, 2005, pp. 437-43.
Fernández-Varón E, Escudero-Pastor E, Cárceles-Rodríguez CM. Pharmacokinetics of an ampicillin-sulbactam combination after intravenous and intramuscular administration to neonatal calves. Vet J. 2005;169(3):437-43.
Fernández-Varón, E., Escudero-Pastor, E., & Cárceles-Rodríguez, C. M. (2005). Pharmacokinetics of an ampicillin-sulbactam combination after intravenous and intramuscular administration to neonatal calves. Veterinary Journal (London, England : 1997), 169(3), 437-43.
Fernández-Varón E, Escudero-Pastor E, Cárceles-Rodríguez CM. Pharmacokinetics of an Ampicillin-sulbactam Combination After Intravenous and Intramuscular Administration to Neonatal Calves. Vet J. 2005;169(3):437-43. PubMed PMID: 15848786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of an ampicillin-sulbactam combination after intravenous and intramuscular administration to neonatal calves. AU - Fernández-Varón,Emilio, AU - Escudero-Pastor,Elisa, AU - Cárceles-Rodríguez,Carlos M, PY - 2004/02/28/accepted PY - 2005/4/26/pubmed PY - 2005/6/14/medline PY - 2005/4/26/entrez SP - 437 EP - 43 JF - Veterinary journal (London, England : 1997) JO - Vet J VL - 169 IS - 3 N2 - The pharmacokinetics of a 2:1 ampicillin-sulbactam combination after intravenous (i.v.) and intramuscular (i.m.) injection at a single dose rate of 20 mg/kg bodyweight (13.33 mg/kg of sodium ampicillin and 6.67 mg/kg of sodium sulbactam) were studied in 10-day-old neonatal calves (n = 10). The plasma concentration-time data of both antibiotics were best fitted to an open two-compartment model after i.v. administration. After i.m. administration, an open two-compartment model demonstrated first order absorption. The apparent volumes of distribution of ampicillin and sulbactam, calculated by the area method, were 0.20+/-0.01 and 0.18+/-0.01 L/kg, respectively, and the total body clearances were 0.51+/-0.03 and 0.21+/-0.01 L/kg h. The elimination half-lives of ampicillin after i.v. and i.m. administration were 0.99+/-0.03 and 1.01+/-0.02 h, respectively, whereas for sulbactam the half-lives were 2.24+/-0.02 and 3.44+/-0.94 h. The bioavailability after i.m. injection was high and similar for both drugs (70.31+/-0.2% for ampicillin and 68.62+/-4.44% for sulbactam). The mean peak plasma concentrations of ampicillin and sulbactam were reached at similar times (0.47+/-0.02 and 0.72+/-0.01 h, respectively) and peak concentrations were also similar but not proportional to the dose administered (17.88+/-0.91 mg/L of ampicillin and 12.92+/-0.79 mg/L of sulbactam). Both drugs had similar pharmacokinetic behaviour after i.m. administration. Since the plasma concentrations of sulbactam were consistently higher during the elimination phase of their disposition, consideration could be given to formulating the ampicillin-sulbactam combination in a ratio higher than 2:1. SN - 1090-0233 UR - https://www.unboundmedicine.com/medline/citation/15848786/Pharmacokinetics_of_an_ampicillin_sulbactam_combination_after_intravenous_and_intramuscular_administration_to_neonatal_calves_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090023304000541 DB - PRIME DP - Unbound Medicine ER -