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The peroxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome.
Clin Endocrinol (Oxf). 2005 May; 62(5):573-9.CE

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and chronic anovulation. The genetic background of the insulin resistance frequently associated with PCOS is unclear.

OBJECTIVES

To examine the influe nce of the Pro12Ala polymorphism of the peroxisome proliferator activated receptor gamma (PPARgamma), which is thought to play a role in the regulation of insulin sensitivity, on endocrine and metabolic parameters in PCOS patients.

METHODS

PPARgamma alleles were analysed in 102 PCOS patients (age 27 +/- 5.3 years) and 104 age matched control women. PCOS was defined by the NIH-criteria as the presence of chronic oligo- or anovulation and hyperandrogenism. Family history and clinical parameters were evaluated by personal interview and physical examination, parameters of insulin resistance [homeostasis model assessment (HOMA) and Matsuda-index] were evaluated with a glucose tolerance test.

RESULTS

Seventy-nine (77.5%) PCOS patients were carriers of the wild-type PPARgamma allele (Pro/Pro), while 23 (22.5%) had at least one Ala allele (X/Ala), with an equal distribution in controls. X/Ala PCOS women were more insulin-sensitive, evidenced by lower fasting insulin, HOMA index and insulin secretion. Differences in insulin resistance did not depend on body mass index. The genotype had no influence on lipid status, leptin, adiponectin, ghrelin, or family history of type 2 diabetes. A significantly lower proportion of Pro/Ala patients had hirsutism and they had on average lower hirsutism scores than Pro/Pro patients. No relationship was found between the Pro/Ala polymorphism and other signs of hyperandrogenism.

CONCLUSION

The Pro12Ala polymorphism of the PPARgamma gene is associated with increased insulin sensitivity and lower hirsutism scores in PCOS women.

Authors+Show Affiliations

Division of Endocrinology, Department of Internal Medicine, University Hospital of Essen, Essen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15853827

Citation

Hahn, Susanne, et al. "The Peroxisome Proliferator Activated Receptor Gamma Pro12Ala Polymorphism Is Associated With a Lower Hirsutism Score and Increased Insulin Sensitivity in Women With Polycystic Ovary Syndrome." Clinical Endocrinology, vol. 62, no. 5, 2005, pp. 573-9.
Hahn S, Fingerhut A, Khomtsiv U, et al. The peroxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2005;62(5):573-9.
Hahn, S., Fingerhut, A., Khomtsiv, U., Khomtsiv, L., Tan, S., Quadbeck, B., Herrmann, B. L., Knebel, B., Müller-Wieland, D., Mann, K., & Janssen, O. E. (2005). The peroxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome. Clinical Endocrinology, 62(5), 573-9.
Hahn S, et al. The Peroxisome Proliferator Activated Receptor Gamma Pro12Ala Polymorphism Is Associated With a Lower Hirsutism Score and Increased Insulin Sensitivity in Women With Polycystic Ovary Syndrome. Clin Endocrinol (Oxf). 2005;62(5):573-9. PubMed PMID: 15853827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The peroxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome. AU - Hahn,Susanne, AU - Fingerhut,Anja, AU - Khomtsiv,Ulyana, AU - Khomtsiv,Liliya, AU - Tan,Susanne, AU - Quadbeck,Beate, AU - Herrmann,Burkhard L, AU - Knebel,Birgit, AU - Müller-Wieland,Dirk, AU - Mann,Klaus, AU - Janssen,Onno E, PY - 2005/4/28/pubmed PY - 2005/7/15/medline PY - 2005/4/28/entrez SP - 573 EP - 9 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 62 IS - 5 N2 - BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and chronic anovulation. The genetic background of the insulin resistance frequently associated with PCOS is unclear. OBJECTIVES: To examine the influe nce of the Pro12Ala polymorphism of the peroxisome proliferator activated receptor gamma (PPARgamma), which is thought to play a role in the regulation of insulin sensitivity, on endocrine and metabolic parameters in PCOS patients. METHODS: PPARgamma alleles were analysed in 102 PCOS patients (age 27 +/- 5.3 years) and 104 age matched control women. PCOS was defined by the NIH-criteria as the presence of chronic oligo- or anovulation and hyperandrogenism. Family history and clinical parameters were evaluated by personal interview and physical examination, parameters of insulin resistance [homeostasis model assessment (HOMA) and Matsuda-index] were evaluated with a glucose tolerance test. RESULTS: Seventy-nine (77.5%) PCOS patients were carriers of the wild-type PPARgamma allele (Pro/Pro), while 23 (22.5%) had at least one Ala allele (X/Ala), with an equal distribution in controls. X/Ala PCOS women were more insulin-sensitive, evidenced by lower fasting insulin, HOMA index and insulin secretion. Differences in insulin resistance did not depend on body mass index. The genotype had no influence on lipid status, leptin, adiponectin, ghrelin, or family history of type 2 diabetes. A significantly lower proportion of Pro/Ala patients had hirsutism and they had on average lower hirsutism scores than Pro/Pro patients. No relationship was found between the Pro/Ala polymorphism and other signs of hyperandrogenism. CONCLUSION: The Pro12Ala polymorphism of the PPARgamma gene is associated with increased insulin sensitivity and lower hirsutism scores in PCOS women. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/15853827/The_peroxisome_proliferator_activated_receptor_gamma_Pro12Ala_polymorphism_is_associated_with_a_lower_hirsutism_score_and_increased_insulin_sensitivity_in_women_with_polycystic_ovary_syndrome_ L2 - https://doi.org/10.1111/j.1365-2265.2005.02261.x DB - PRIME DP - Unbound Medicine ER -