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Characteristics of gastritis in patients with Helicobacter pylori-positive reflux esophagitis.
J Gastroenterol Hepatol. 2005 May; 20(5):682-7.JG

Abstract

BACKGROUND AND AIM

The influence of Helicobacter pylori on gastric acid secretion differs with the status of gastritis. The histological characteristics of gastritis in H. pylori-positive patients with reflux esophagitis have not been fully investigated. We therefore studied the pattern of endoscopic gastric mucosal atrophy and degree of histological gastritis in such patients.

METHODS

Subjects comprised 41 H. pylori-positive patients with reflux esophagitis, 41 age- and sex-matched patients with duodenal ulcer, and 41 patients with early gastric cancer. The endoscopic pattern of gastric mucosal atrophy was reviewed, and the degree of histological gastritis in biopsy specimens from the antrum and corpus was assessed in accordance with the updated Sydney system.

RESULTS

The grade of endoscopic and histological gastric mucosal atrophy in patients with reflux esophagitis was significantly lower than that in patients with gastric cancer, and the histological scores for antral atrophy and metaplasia in patients with reflux esophagitis tended to be lower than those in patients with duodenal ulcer. In patients with reflux esophagitis and duodenal ulcer, the scores for antral inflammation and activity tended to be higher than those for the corpus. Conversely, the inflammation and activity score in patients with early gastric cancer showed a corpus-predominant gastritis pattern.

CONCLUSION

In H. pylori-positive patients with reflux esophagitis, the degree of endoscopic gastric mucosal atrophy is low and histologically there is an antral-predominant gastritis pattern. Therefore, gastric acid secretion in H. pylori-positive patients with reflux esophagitis may be augmented by H. pylori infection.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Shimane University, School of Medicine, Izumo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15853979

Citation

Mihara, Takafumi, et al. "Characteristics of Gastritis in Patients With Helicobacter Pylori-positive Reflux Esophagitis." Journal of Gastroenterology and Hepatology, vol. 20, no. 5, 2005, pp. 682-7.
Mihara T, Adachi K, Komazawa Y, et al. Characteristics of gastritis in patients with Helicobacter pylori-positive reflux esophagitis. J Gastroenterol Hepatol. 2005;20(5):682-7.
Mihara, T., Adachi, K., Komazawa, Y., Yoshida, M., Araki, A., Maruyama, R., Furuta, K., Ishihara, S., Amano, Y., & Kinoshita, Y. (2005). Characteristics of gastritis in patients with Helicobacter pylori-positive reflux esophagitis. Journal of Gastroenterology and Hepatology, 20(5), 682-7.
Mihara T, et al. Characteristics of Gastritis in Patients With Helicobacter Pylori-positive Reflux Esophagitis. J Gastroenterol Hepatol. 2005;20(5):682-7. PubMed PMID: 15853979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of gastritis in patients with Helicobacter pylori-positive reflux esophagitis. AU - Mihara,Takafumi, AU - Adachi,Kyoichi, AU - Komazawa,Yoshinori, AU - Yoshida,Manabu, AU - Araki,Asuka, AU - Maruyama,Riruke, AU - Furuta,Kenji, AU - Ishihara,Shunji, AU - Amano,Yuji, AU - Kinoshita,Yoshikazu, PY - 2005/4/28/pubmed PY - 2005/9/9/medline PY - 2005/4/28/entrez SP - 682 EP - 7 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 20 IS - 5 N2 - BACKGROUND AND AIM: The influence of Helicobacter pylori on gastric acid secretion differs with the status of gastritis. The histological characteristics of gastritis in H. pylori-positive patients with reflux esophagitis have not been fully investigated. We therefore studied the pattern of endoscopic gastric mucosal atrophy and degree of histological gastritis in such patients. METHODS: Subjects comprised 41 H. pylori-positive patients with reflux esophagitis, 41 age- and sex-matched patients with duodenal ulcer, and 41 patients with early gastric cancer. The endoscopic pattern of gastric mucosal atrophy was reviewed, and the degree of histological gastritis in biopsy specimens from the antrum and corpus was assessed in accordance with the updated Sydney system. RESULTS: The grade of endoscopic and histological gastric mucosal atrophy in patients with reflux esophagitis was significantly lower than that in patients with gastric cancer, and the histological scores for antral atrophy and metaplasia in patients with reflux esophagitis tended to be lower than those in patients with duodenal ulcer. In patients with reflux esophagitis and duodenal ulcer, the scores for antral inflammation and activity tended to be higher than those for the corpus. Conversely, the inflammation and activity score in patients with early gastric cancer showed a corpus-predominant gastritis pattern. CONCLUSION: In H. pylori-positive patients with reflux esophagitis, the degree of endoscopic gastric mucosal atrophy is low and histologically there is an antral-predominant gastritis pattern. Therefore, gastric acid secretion in H. pylori-positive patients with reflux esophagitis may be augmented by H. pylori infection. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/15853979/Characteristics_of_gastritis_in_patients_with_Helicobacter_pylori_positive_reflux_esophagitis_ L2 - https://doi.org/10.1111/j.1440-1746.2005.03779.x DB - PRIME DP - Unbound Medicine ER -