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Clinical features of HBsAg-negative but anti-HBc-positive hepatocellular carcinoma in a hepatitis B virus endemic area.
J Gastroenterol Hepatol 2005; 20(5):746-51JG

Abstract

BACKGROUND

The presence of antibody to the hepatitis B core antigen (anti-HBc) IgG in serum usually means a past infection of the hepatitis B virus (HBV). The clinical characteristics of patients with hepatocellular carcinoma (HCC), who have only a marker for past HBV infection, were investigated.

METHODS

A total of 565 HCC patients were classified according to their markers for HBV and the hepatitis C virus (HCV). The clinical features and the survival rate of hepatitis B surface antigen (HBsAg)(-)/anti-HBc(+) patients were compared to those of HBsAg(+) patients.

RESULTS

Four hundred and three patients were positive for HBsAg (B group, 71.3%), 64 were positive for anti-HCV (11.3%), and 90 were negative for both HBsAg and anti-HCV (N group, 15.9%). In the N group, 71 were positive for anti-HBc (PB group, 12.6% of total patients). The clinical characteristics of the PB group were different from those of the B group: age at diagnosis (60.6 +/- 9.6 vs 53.3 +/- 10.6 years, P < 0.001), habitual drinking (59.2% vs 23.6%, P < 0.001), family history of liver disease (9.9% vs 38.9%, P < 0.005), detection with periodic screening (28.2% vs 50.4%, P < 0.001), and elevated alpha-fetoprotein (53.5% vs 76.2%, P < 0.001). In both the PB group and the B group, liver cirrhosis was accompanied by a similar high prevalence (74.6% vs 89.1%). However, there was no significant difference in the cumulative survival rate.

CONCLUSIONS

The prevalence of HBsAg(-)/anti-HBc(+) HCC is not rare or more common than that of anti-HCV(+) HCC in Korea, a high HBV endemic area. Although some differences in clinical characteristics may imply a different pathogenesis, chronic HBV infection or habitual drinking may be major contributing factors in the development of HCC in these patients.

Authors+Show Affiliations

Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15853989

Citation

Shim, Jaejun, et al. "Clinical Features of HBsAg-negative but anti-HBc-positive Hepatocellular Carcinoma in a Hepatitis B Virus Endemic Area." Journal of Gastroenterology and Hepatology, vol. 20, no. 5, 2005, pp. 746-51.
Shim J, Kim BH, Kim NH, et al. Clinical features of HBsAg-negative but anti-HBc-positive hepatocellular carcinoma in a hepatitis B virus endemic area. J Gastroenterol Hepatol. 2005;20(5):746-51.
Shim, J., Kim, B. H., Kim, N. H., Dong, S. H., Kim, H. J., Chang, Y. W., ... Chang, R. (2005). Clinical features of HBsAg-negative but anti-HBc-positive hepatocellular carcinoma in a hepatitis B virus endemic area. Journal of Gastroenterology and Hepatology, 20(5), pp. 746-51.
Shim J, et al. Clinical Features of HBsAg-negative but anti-HBc-positive Hepatocellular Carcinoma in a Hepatitis B Virus Endemic Area. J Gastroenterol Hepatol. 2005;20(5):746-51. PubMed PMID: 15853989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features of HBsAg-negative but anti-HBc-positive hepatocellular carcinoma in a hepatitis B virus endemic area. AU - Shim,Jaejun, AU - Kim,Byung-Ho, AU - Kim,Nam Hoon, AU - Dong,Seok Ho, AU - Kim,Hyo Jong, AU - Chang,Young Woon, AU - Lee,Joung Il, AU - Chang,Rin, PY - 2005/4/28/pubmed PY - 2005/9/9/medline PY - 2005/4/28/entrez SP - 746 EP - 51 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 20 IS - 5 N2 - BACKGROUND: The presence of antibody to the hepatitis B core antigen (anti-HBc) IgG in serum usually means a past infection of the hepatitis B virus (HBV). The clinical characteristics of patients with hepatocellular carcinoma (HCC), who have only a marker for past HBV infection, were investigated. METHODS: A total of 565 HCC patients were classified according to their markers for HBV and the hepatitis C virus (HCV). The clinical features and the survival rate of hepatitis B surface antigen (HBsAg)(-)/anti-HBc(+) patients were compared to those of HBsAg(+) patients. RESULTS: Four hundred and three patients were positive for HBsAg (B group, 71.3%), 64 were positive for anti-HCV (11.3%), and 90 were negative for both HBsAg and anti-HCV (N group, 15.9%). In the N group, 71 were positive for anti-HBc (PB group, 12.6% of total patients). The clinical characteristics of the PB group were different from those of the B group: age at diagnosis (60.6 +/- 9.6 vs 53.3 +/- 10.6 years, P < 0.001), habitual drinking (59.2% vs 23.6%, P < 0.001), family history of liver disease (9.9% vs 38.9%, P < 0.005), detection with periodic screening (28.2% vs 50.4%, P < 0.001), and elevated alpha-fetoprotein (53.5% vs 76.2%, P < 0.001). In both the PB group and the B group, liver cirrhosis was accompanied by a similar high prevalence (74.6% vs 89.1%). However, there was no significant difference in the cumulative survival rate. CONCLUSIONS: The prevalence of HBsAg(-)/anti-HBc(+) HCC is not rare or more common than that of anti-HCV(+) HCC in Korea, a high HBV endemic area. Although some differences in clinical characteristics may imply a different pathogenesis, chronic HBV infection or habitual drinking may be major contributing factors in the development of HCC in these patients. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/15853989/Clinical_features_of_HBsAg_negative_but_anti_HBc_positive_hepatocellular_carcinoma_in_a_hepatitis_B_virus_endemic_area_ L2 - https://doi.org/10.1111/j.1440-1746.2005.03747.x DB - PRIME DP - Unbound Medicine ER -