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Euphorbia thymifolia suppresses herpes simplex virus-2 infection by directly inactivating virus infectivity.
Clin Exp Pharmacol Physiol. 2005 May-Jun; 32(5-6):346-9.CE

Abstract

1. The ethyl acetate (EtOAc) extract and 3-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-d-glucose (3OG46HG) of Euphorbia thymifolia Linnea have been shown to exhibit anti-herpes simplex virus (HSV)-2 activity in vitro. In the present study, we investigated the mode of action of these two compounds in suppressing HSV-2 multiplication. 2. The results demonstrated that the EtOAc extract and 3OG46HG affected virus infectivity in a dose-dependent manner. The EtOAc extract significantly reduced virus infectivity at a concentration of 4.0 microg/mL, whereas 3OG46HG obviously diminished virus infectivity at concentration of a 0.5 microg/mL. The virucidal ability of the EtOAc extract was affected by the incubation period, but not by the incubation temperature. In the case of the action of 3OG46HG against HSV-2, the effects of incubation time and temperature were negligible. 3. In summary, the EtOAc extract and 3OG46HG of E. thymifolia are concluded to inhibit HSV-2 multiplication by reducing virus infectivity.

Authors+Show Affiliations

Yang CM
Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Cheng HY
No affiliation info available
Lin TC
No affiliation info available
Chiang LC
No affiliation info available
Lin CC
No affiliation info available

MeSH

AnimalsAntiviral AgentsChlorocebus aethiopsDose-Response Relationship, DrugEuphorbiaHerpes SimplexHerpesvirus 2, HumanPlant ExtractsVero Cells

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15854140

Citation

Yang, Chien-Min, et al. "Euphorbia Thymifolia Suppresses Herpes Simplex Virus-2 Infection By Directly Inactivating Virus Infectivity." Clinical and Experimental Pharmacology & Physiology, vol. 32, no. 5-6, 2005, pp. 346-9.
Yang CM, Cheng HY, Lin TC, et al. Euphorbia thymifolia suppresses herpes simplex virus-2 infection by directly inactivating virus infectivity. Clin Exp Pharmacol Physiol. 2005;32(5-6):346-9.
Yang, C. M., Cheng, H. Y., Lin, T. C., Chiang, L. C., & Lin, C. C. (2005). Euphorbia thymifolia suppresses herpes simplex virus-2 infection by directly inactivating virus infectivity. Clinical and Experimental Pharmacology & Physiology, 32(5-6), 346-9.
Yang CM, et al. Euphorbia Thymifolia Suppresses Herpes Simplex Virus-2 Infection By Directly Inactivating Virus Infectivity. Clin Exp Pharmacol Physiol. 2005 May-Jun;32(5-6):346-9. PubMed PMID: 15854140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Euphorbia thymifolia suppresses herpes simplex virus-2 infection by directly inactivating virus infectivity. AU - Yang,Chien-Min, AU - Cheng,Hua-Yew, AU - Lin,Ta-Chen, AU - Chiang,Lien-Chai, AU - Lin,Chun-Ching, PY - 2005/4/28/pubmed PY - 2006/1/18/medline PY - 2005/4/28/entrez SP - 346 EP - 9 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 32 IS - 5-6 N2 - 1. The ethyl acetate (EtOAc) extract and 3-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-d-glucose (3OG46HG) of Euphorbia thymifolia Linnea have been shown to exhibit anti-herpes simplex virus (HSV)-2 activity in vitro. In the present study, we investigated the mode of action of these two compounds in suppressing HSV-2 multiplication. 2. The results demonstrated that the EtOAc extract and 3OG46HG affected virus infectivity in a dose-dependent manner. The EtOAc extract significantly reduced virus infectivity at a concentration of 4.0 microg/mL, whereas 3OG46HG obviously diminished virus infectivity at concentration of a 0.5 microg/mL. The virucidal ability of the EtOAc extract was affected by the incubation period, but not by the incubation temperature. In the case of the action of 3OG46HG against HSV-2, the effects of incubation time and temperature were negligible. 3. In summary, the EtOAc extract and 3OG46HG of E. thymifolia are concluded to inhibit HSV-2 multiplication by reducing virus infectivity. SN - 0305-1870 UR - https://www.unboundmedicine.com/medline/citation/15854140/Euphorbia_thymifolia_suppresses_herpes_simplex_virus_2_infection_by_directly_inactivating_virus_infectivity_ DB - PRIME DP - Unbound Medicine ER -