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The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies.
Neurosci Lett. 2005 May 20-27; 380(1-2):161-5.NL

Abstract

We immunohistochemically investigated the degeneration processes of the nigro-striatal and nigro-amygdaloid pathways and the relationship between the loss of dopaminergic neurons and Lewy bodies (LB) formation in the substantia nigra using 15 autopsied cases of dementia with Lewy bodies (DLB). The number of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra and TH-positive axonal terminals in the putamen decreased with a specific pattern. The substantia nigra possessed alpha-synuclein-positive LB-bearing neurons that were almost evenly distributed, while the putamen exhibited diffuse or granular alpha-synuclein-immunostaining. Most of the granular stains were positive for anti-phosphorylated alpha-synuclein antibody, whereas the diffuse stains were negative. These findings suggest that the axonal terminals in the putamen undergo abnormal alpha-synuclein accumulation, but may not always originate from LB-bearing neurons in the substantia nigra. The central amygdaloid nucleus contained anti-alpha-synuclein- and -phosphorylated alpha-synuclein-positive dystrophic axonal terminals, the degree of which was greater for cases with granular staining in the putamen, and which was proportional to the number of alpha-synuclein-positive neurons in the substantia nigra. Thus, the axonal terminals in the central amygdaloid nucleus may have originated from LB-bearing neurons in the substantia nigra. The results of the present study indicate that the nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in DLB, and suggest that the degeneration of the nigro-amygdaloid pathway more strongly reflects LB formation in dopaminergic neurons of the substantia nigra than that of the nigro-striatal pathway. In addition, they indicate that there is no direct relationship between the loss of dopaminergic neurons and LB formation in the substantia nigra.

Authors+Show Affiliations

Department of Psychiatry, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, Tokyo 136-0075, Japan. iseki@juntendo.gmc.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15854770

Citation

Iseki, Eizo, et al. "The Nigro-striatal and Nigro-amygdaloid Pathways Undergo Different Degeneration Processes in Brains of Dementia With Lewy Bodies." Neuroscience Letters, vol. 380, no. 1-2, 2005, pp. 161-5.
Iseki E, Marui W, Yamamoto R, et al. The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies. Neurosci Lett. 2005;380(1-2):161-5.
Iseki, E., Marui, W., Yamamoto, R., Togo, T., Katsuse, O., Kato, M., Iwatsubo, T., Kosaka, K., & Arai, H. (2005). The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies. Neuroscience Letters, 380(1-2), 161-5.
Iseki E, et al. The Nigro-striatal and Nigro-amygdaloid Pathways Undergo Different Degeneration Processes in Brains of Dementia With Lewy Bodies. Neurosci Lett. 2005 May 20-27;380(1-2):161-5. PubMed PMID: 15854770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies. AU - Iseki,Eizo, AU - Marui,Wami, AU - Yamamoto,Ryoko, AU - Togo,Takashi, AU - Katsuse,Omi, AU - Kato,Masanori, AU - Iwatsubo,Takeshi, AU - Kosaka,Kenji, AU - Arai,Heii, Y1 - 2005/02/03/ PY - 2004/12/22/received PY - 2005/01/11/revised PY - 2005/01/12/accepted PY - 2005/4/28/pubmed PY - 2005/7/29/medline PY - 2005/4/28/entrez SP - 161 EP - 5 JF - Neuroscience letters JO - Neurosci Lett VL - 380 IS - 1-2 N2 - We immunohistochemically investigated the degeneration processes of the nigro-striatal and nigro-amygdaloid pathways and the relationship between the loss of dopaminergic neurons and Lewy bodies (LB) formation in the substantia nigra using 15 autopsied cases of dementia with Lewy bodies (DLB). The number of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra and TH-positive axonal terminals in the putamen decreased with a specific pattern. The substantia nigra possessed alpha-synuclein-positive LB-bearing neurons that were almost evenly distributed, while the putamen exhibited diffuse or granular alpha-synuclein-immunostaining. Most of the granular stains were positive for anti-phosphorylated alpha-synuclein antibody, whereas the diffuse stains were negative. These findings suggest that the axonal terminals in the putamen undergo abnormal alpha-synuclein accumulation, but may not always originate from LB-bearing neurons in the substantia nigra. The central amygdaloid nucleus contained anti-alpha-synuclein- and -phosphorylated alpha-synuclein-positive dystrophic axonal terminals, the degree of which was greater for cases with granular staining in the putamen, and which was proportional to the number of alpha-synuclein-positive neurons in the substantia nigra. Thus, the axonal terminals in the central amygdaloid nucleus may have originated from LB-bearing neurons in the substantia nigra. The results of the present study indicate that the nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in DLB, and suggest that the degeneration of the nigro-amygdaloid pathway more strongly reflects LB formation in dopaminergic neurons of the substantia nigra than that of the nigro-striatal pathway. In addition, they indicate that there is no direct relationship between the loss of dopaminergic neurons and LB formation in the substantia nigra. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15854770/The_nigro_striatal_and_nigro_amygdaloid_pathways_undergo_different_degeneration_processes_in_brains_of_dementia_with_Lewy_bodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(05)00094-7 DB - PRIME DP - Unbound Medicine ER -