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Melt sonocrystallization of ibuprofen: effect on crystal properties.
Eur J Pharm Sci. 2005 May; 25(1):41-8.EJ

Abstract

This study deals with development of melt sonocrystallization technique for ibuprofen agglomerates and characterization of their physicochemical, micromeritic and compressional properties. Melt sonocrystallization process was developed for ibuprofen in which ibuprofen melt was poured in deionized water maintained at 25 degrees C and simultaneously subjected to ultrasonic energy. The agglomerates obtained were evaluated using Scanning electron microscopy (SEM), Differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), Fourier transformed infrared spectroscopy (FTIR), intrinsic dissolution rate, BET analysis, solubility, image analysis, Heckel plot analysis and friability studies. The irregular agglomerates with porous surface were obtained. The agglomerates comprised of crystals having different crystal habits such as needles, plates, and some hollow tubes. Solubility, specific surface area and intrinsic dissolution rate increased with the treatment of ultrasonic energy. SEM and XRPD confirmed crystal habit changes. Improvement in compressional properties and reduction in sticking was observed due to the change in crystal habit. Crystal habit changes and lattice defects during processing have caused favorable changes in the physicochemical and compressional properties of the drug.

Authors+Show Affiliations

Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune 411038, Maharashtra State, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15854799

Citation

Manish, Maheshwari, et al. "Melt Sonocrystallization of Ibuprofen: Effect On Crystal Properties." European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, vol. 25, no. 1, 2005, pp. 41-8.
Manish M, Harshal J, Anant P. Melt sonocrystallization of ibuprofen: effect on crystal properties. Eur J Pharm Sci. 2005;25(1):41-8.
Manish, M., Harshal, J., & Anant, P. (2005). Melt sonocrystallization of ibuprofen: effect on crystal properties. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 25(1), 41-8.
Manish M, Harshal J, Anant P. Melt Sonocrystallization of Ibuprofen: Effect On Crystal Properties. Eur J Pharm Sci. 2005;25(1):41-8. PubMed PMID: 15854799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melt sonocrystallization of ibuprofen: effect on crystal properties. AU - Manish,Maheshwari, AU - Harshal,Jahagirdar, AU - Anant,Paradkar, PY - 2004/08/20/received PY - 2005/01/11/revised PY - 2005/01/14/accepted PY - 2005/4/28/pubmed PY - 2005/8/12/medline PY - 2005/4/28/entrez SP - 41 EP - 8 JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences JO - Eur J Pharm Sci VL - 25 IS - 1 N2 - This study deals with development of melt sonocrystallization technique for ibuprofen agglomerates and characterization of their physicochemical, micromeritic and compressional properties. Melt sonocrystallization process was developed for ibuprofen in which ibuprofen melt was poured in deionized water maintained at 25 degrees C and simultaneously subjected to ultrasonic energy. The agglomerates obtained were evaluated using Scanning electron microscopy (SEM), Differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), Fourier transformed infrared spectroscopy (FTIR), intrinsic dissolution rate, BET analysis, solubility, image analysis, Heckel plot analysis and friability studies. The irregular agglomerates with porous surface were obtained. The agglomerates comprised of crystals having different crystal habits such as needles, plates, and some hollow tubes. Solubility, specific surface area and intrinsic dissolution rate increased with the treatment of ultrasonic energy. SEM and XRPD confirmed crystal habit changes. Improvement in compressional properties and reduction in sticking was observed due to the change in crystal habit. Crystal habit changes and lattice defects during processing have caused favorable changes in the physicochemical and compressional properties of the drug. SN - 0928-0987 UR - https://www.unboundmedicine.com/medline/citation/15854799/Melt_sonocrystallization_of_ibuprofen:_effect_on_crystal_properties_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-0987(05)00051-5 DB - PRIME DP - Unbound Medicine ER -