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Is there a relationship between childhood Helicobacter pylori infection and iron deficiency anemia?
J Trop Pediatr. 2005 Jun; 51(3):166-9.JT

Abstract

An association between Helicobacter pylori infection and iron deficiency anemia has been reported in children, and it has been proposed that H. pylori infection needs to be eradicated to treat absolutely iron deficiency anemia (IDA). We investigated whether there was any correlation between H. pylori infection and iron deficiency (ID) and IDA in children, and whether the eradication of H. pylori infection without iron treatment would lead to the resolution of ID. Hemoglobin and ferritin levels, H. pylori stool antigen test and (14)C urea breath test were measured in 140 children aged 6--16 years (median 9.5 years). Children with H. pylori infection were divided into three groups on the basis of hemoglobin, mean corpuscular volume (MCV), and serum ferritin levels: groups of IDA, ID, and control. All the children received anti-H. pylori combination therapy consisting of amoxicillin, clarithromycin, and lansoprazole. Hemoglobin and MCV values rose significantly compared with baseline values after H. pylori eradication without iron supplementation in children with IDA (p=0.002 and p=0.003, respectively). Ferritin values increased significantly after H. pylori eradication in children with ID (p<0.001). We conclude that complete recovery of ID and IDA can be achieved with H. pylori eradication without iron supplementation in children with H. pylori infection.

Authors+Show Affiliations

Department of Pediatric Hematology, Gülhane Military Medical Academy, Ankara, Turkey. ekurekci@gata.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15855306

Citation

Kurekci, A E., et al. "Is There a Relationship Between Childhood Helicobacter Pylori Infection and Iron Deficiency Anemia?" Journal of Tropical Pediatrics, vol. 51, no. 3, 2005, pp. 166-9.
Kurekci AE, Atay AA, Sarici SU, et al. Is there a relationship between childhood Helicobacter pylori infection and iron deficiency anemia? J Trop Pediatr. 2005;51(3):166-9.
Kurekci, A. E., Atay, A. A., Sarici, S. U., Yesilkaya, E., Senses, Z., Okutan, V., & Ozcan, O. (2005). Is there a relationship between childhood Helicobacter pylori infection and iron deficiency anemia? Journal of Tropical Pediatrics, 51(3), 166-9.
Kurekci AE, et al. Is There a Relationship Between Childhood Helicobacter Pylori Infection and Iron Deficiency Anemia. J Trop Pediatr. 2005;51(3):166-9. PubMed PMID: 15855306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there a relationship between childhood Helicobacter pylori infection and iron deficiency anemia? AU - Kurekci,A E, AU - Atay,A A, AU - Sarici,S U, AU - Yesilkaya,Ediz, AU - Senses,Zeynep, AU - Okutan,Vedat, AU - Ozcan,Okan, Y1 - 2005/04/26/ PY - 2005/4/28/pubmed PY - 2005/9/1/medline PY - 2005/4/28/entrez SP - 166 EP - 9 JF - Journal of tropical pediatrics JO - J Trop Pediatr VL - 51 IS - 3 N2 - An association between Helicobacter pylori infection and iron deficiency anemia has been reported in children, and it has been proposed that H. pylori infection needs to be eradicated to treat absolutely iron deficiency anemia (IDA). We investigated whether there was any correlation between H. pylori infection and iron deficiency (ID) and IDA in children, and whether the eradication of H. pylori infection without iron treatment would lead to the resolution of ID. Hemoglobin and ferritin levels, H. pylori stool antigen test and (14)C urea breath test were measured in 140 children aged 6--16 years (median 9.5 years). Children with H. pylori infection were divided into three groups on the basis of hemoglobin, mean corpuscular volume (MCV), and serum ferritin levels: groups of IDA, ID, and control. All the children received anti-H. pylori combination therapy consisting of amoxicillin, clarithromycin, and lansoprazole. Hemoglobin and MCV values rose significantly compared with baseline values after H. pylori eradication without iron supplementation in children with IDA (p=0.002 and p=0.003, respectively). Ferritin values increased significantly after H. pylori eradication in children with ID (p<0.001). We conclude that complete recovery of ID and IDA can be achieved with H. pylori eradication without iron supplementation in children with H. pylori infection. SN - 0142-6338 UR - https://www.unboundmedicine.com/medline/citation/15855306/Is_there_a_relationship_between_childhood_Helicobacter_pylori_infection_and_iron_deficiency_anemia L2 - https://academic.oup.com/tropej/article-lookup/doi/10.1093/tropej/fmi015 DB - PRIME DP - Unbound Medicine ER -