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Magnesium deficiency is associated with insulin resistance in obese children.
Diabetes Care 2005; 28(5):1175-81DC

Abstract

OBJECTIVE

Magnesium deficiency has been associated with insulin resistance (IR) and increased risk for type 2 diabetes in adults. This study was designed to determine whether obese children exhibit serum or dietary magnesium deficiency and its potential association with IR.

RESEARCH DESIGN AND METHODS

We studied 24 obese nondiabetic children (BMI > or =85th percentile) and 24 sex- and puberty-matched lean control subjects (BMI <85th percentile). We measured serum magnesium, indexes of insulin sensitivity, dietary magnesium intake (using a food frequency questionnaire), and body composition (by air displacement plethysmography).

RESULTS

Serum magnesium was significantly lower in obese children (0.748 +/- 0.015 mmol/l, means +/- SE) compared with lean children (0.801 +/- 0.012 mmol/l) (P = 0.009). Serum magnesium was inversely correlated with fasting insulin (r(s) = -0.36 [95% CI -0.59 to -0.08]; P = 0.011) and positively correlated with quantitative insulin sensitivity check index (QUICKI) (0.35 [0.06-0.58]; P = 0.015). Dietary magnesium intake was significantly lower in obese children (obese: 0.12 +/- 0.004 vs. lean: 0.14 +/- 0.004 mg/kcal; P = 0.003). Dietary magnesium intake was inversely associated with fasting insulin (-0.43 [-0.64 to -0.16]; P = 0.002) and directly correlated with QUICKI (0.43 [0.16-0.64]; P = 0.002).

CONCLUSIONS

The association between magnesium deficiency and IR is present during childhood. Serum magnesium deficiency in obese children may be secondary to decreased dietary magnesium intake. Magnesium supplementation or increased intake of magnesium-rich foods may be an important tool in the prevention of type 2 diabetes in obese children.

Authors+Show Affiliations

University of Virginia, Department of Pediatrics, Box 800386, Charlottesville, VA 22908, USA. mgh2k@virginia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15855585

Citation

Huerta, Milagros G., et al. "Magnesium Deficiency Is Associated With Insulin Resistance in Obese Children." Diabetes Care, vol. 28, no. 5, 2005, pp. 1175-81.
Huerta MG, Roemmich JN, Kington ML, et al. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care. 2005;28(5):1175-81.
Huerta, M. G., Roemmich, J. N., Kington, M. L., Bovbjerg, V. E., Weltman, A. L., Holmes, V. F., ... Nadler, J. L. (2005). Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care, 28(5), pp. 1175-81.
Huerta MG, et al. Magnesium Deficiency Is Associated With Insulin Resistance in Obese Children. Diabetes Care. 2005;28(5):1175-81. PubMed PMID: 15855585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium deficiency is associated with insulin resistance in obese children. AU - Huerta,Milagros G, AU - Roemmich,James N, AU - Kington,Marit L, AU - Bovbjerg,Viktor E, AU - Weltman,Arthur L, AU - Holmes,Viola F, AU - Patrie,James T, AU - Rogol,Alan D, AU - Nadler,Jerry L, PY - 2005/4/28/pubmed PY - 2005/8/6/medline PY - 2005/4/28/entrez SP - 1175 EP - 81 JF - Diabetes care JO - Diabetes Care VL - 28 IS - 5 N2 - OBJECTIVE: Magnesium deficiency has been associated with insulin resistance (IR) and increased risk for type 2 diabetes in adults. This study was designed to determine whether obese children exhibit serum or dietary magnesium deficiency and its potential association with IR. RESEARCH DESIGN AND METHODS: We studied 24 obese nondiabetic children (BMI > or =85th percentile) and 24 sex- and puberty-matched lean control subjects (BMI <85th percentile). We measured serum magnesium, indexes of insulin sensitivity, dietary magnesium intake (using a food frequency questionnaire), and body composition (by air displacement plethysmography). RESULTS: Serum magnesium was significantly lower in obese children (0.748 +/- 0.015 mmol/l, means +/- SE) compared with lean children (0.801 +/- 0.012 mmol/l) (P = 0.009). Serum magnesium was inversely correlated with fasting insulin (r(s) = -0.36 [95% CI -0.59 to -0.08]; P = 0.011) and positively correlated with quantitative insulin sensitivity check index (QUICKI) (0.35 [0.06-0.58]; P = 0.015). Dietary magnesium intake was significantly lower in obese children (obese: 0.12 +/- 0.004 vs. lean: 0.14 +/- 0.004 mg/kcal; P = 0.003). Dietary magnesium intake was inversely associated with fasting insulin (-0.43 [-0.64 to -0.16]; P = 0.002) and directly correlated with QUICKI (0.43 [0.16-0.64]; P = 0.002). CONCLUSIONS: The association between magnesium deficiency and IR is present during childhood. Serum magnesium deficiency in obese children may be secondary to decreased dietary magnesium intake. Magnesium supplementation or increased intake of magnesium-rich foods may be an important tool in the prevention of type 2 diabetes in obese children. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/15855585/full_citation L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=15855585 DB - PRIME DP - Unbound Medicine ER -