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Phytosterols in nonfat and low-fat beverages have no impact on the LDL size phenotype.
Eur J Clin Nutr 2005; 59(6):801-4EJ

Abstract

OBJECTIVE

To examine the impact of nonfat and low-fat phytosterol-enriched beverages on low-density lipoprotein (LDL) electrophoretic characteristics.

DESIGN

Double-blind, randomized, crossover, placebo-controlled dietary trial.

SETTING

Diets were prepared and consumed at the Mary Emily Clinical Nutrition Research Unit of McGill University. Analyses were performed at the Institute on Nutraceuticals and Functional Foods of Laval University.

SUBJECTS AND INTERVENTION

In total, 15 moderately hypercholesterolemic persons consumed each of three experimental diets that each comprised a different beverage: nonfat placebo (NF control), nonfat with phytosterols (NFPS) or low-fat with phytosterols (LFPS). Participants consumed three beverages daily at meal time for a total of 1.8 g of phytosterols per day. Nondenaturing 2-16% polyacrylamide gradient gel electrophoreses were used to characterize LDL size characteristics.

RESULTS

The NFPS and LFPS beverage induced no significant changes in several features of the LDL size phenotype compared to the control diet.

CONCLUSION

The consumption of phytosterol-supplemented nonfat and low-fat beverages is not associated with clinically meaningful changes in the LDL particle size phenotype.

Authors+Show Affiliations

Institute on Nutraceuticals and Functional Foods, Laval University, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15856068

Citation

Charest, A, et al. "Phytosterols in Nonfat and Low-fat Beverages Have No Impact On the LDL Size Phenotype." European Journal of Clinical Nutrition, vol. 59, no. 6, 2005, pp. 801-4.
Charest A, Vanstone C, St-Onge MP, et al. Phytosterols in nonfat and low-fat beverages have no impact on the LDL size phenotype. Eur J Clin Nutr. 2005;59(6):801-4.
Charest, A., Vanstone, C., St-Onge, M. P., Parson, W., Jones, P. J., & Lamarche, B. (2005). Phytosterols in nonfat and low-fat beverages have no impact on the LDL size phenotype. European Journal of Clinical Nutrition, 59(6), pp. 801-4.
Charest A, et al. Phytosterols in Nonfat and Low-fat Beverages Have No Impact On the LDL Size Phenotype. Eur J Clin Nutr. 2005;59(6):801-4. PubMed PMID: 15856068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytosterols in nonfat and low-fat beverages have no impact on the LDL size phenotype. AU - Charest,A, AU - Vanstone,C, AU - St-Onge,M P, AU - Parson,W, AU - Jones,P J H, AU - Lamarche,B, PY - 2005/4/28/pubmed PY - 2005/9/30/medline PY - 2005/4/28/entrez SP - 801 EP - 4 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 IS - 6 N2 - OBJECTIVE: To examine the impact of nonfat and low-fat phytosterol-enriched beverages on low-density lipoprotein (LDL) electrophoretic characteristics. DESIGN: Double-blind, randomized, crossover, placebo-controlled dietary trial. SETTING: Diets were prepared and consumed at the Mary Emily Clinical Nutrition Research Unit of McGill University. Analyses were performed at the Institute on Nutraceuticals and Functional Foods of Laval University. SUBJECTS AND INTERVENTION: In total, 15 moderately hypercholesterolemic persons consumed each of three experimental diets that each comprised a different beverage: nonfat placebo (NF control), nonfat with phytosterols (NFPS) or low-fat with phytosterols (LFPS). Participants consumed three beverages daily at meal time for a total of 1.8 g of phytosterols per day. Nondenaturing 2-16% polyacrylamide gradient gel electrophoreses were used to characterize LDL size characteristics. RESULTS: The NFPS and LFPS beverage induced no significant changes in several features of the LDL size phenotype compared to the control diet. CONCLUSION: The consumption of phytosterol-supplemented nonfat and low-fat beverages is not associated with clinically meaningful changes in the LDL particle size phenotype. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/15856068/Phytosterols_in_nonfat_and_low_fat_beverages_have_no_impact_on_the_LDL_size_phenotype_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602142 DB - PRIME DP - Unbound Medicine ER -