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Green tea drinking and multigenetic index on the risk of stomach cancer in a Chinese population.
Int J Cancer. 2005 Oct 10; 116(6):972-83.IJ

Abstract

The purpose of our study was to examine the roles of green tea drinking, other risk and protective factors, and polymorphism of susceptibility genes such as GSTM1, GSTT1, GSTP1, and p53 codon 72 and their possible joint effects on the risk of stomach cancer. A population-based case-control study was conducted in Taixing, China, including 206 newly diagnosed cases with stomach cancer and 415 healthy control subjects. Epidemiological data were collected by in-person interviews using a standard questionnaire. Polymorphisms of susceptibility genes were assayed by PCR-RFLP techniques. A multigenetic index was created by summing up the number of risk genotypes. The data were analyzed using the logistic regression model. A reverse association between green tea drinking and risk of stomach cancer was observed with an adjusted odds ratio (OR) of 0.59 (95% confidence interval [CI] = 0.34-1.01). Dose-response relationship was shown (p-trend < 0.05). A higher score on the multigenetic index was associated with increased risk of stomach cancer with an adjusted OR of 2.21 (95% CI = 1.02-4.79) for those with at least 3 risk genotypes compared to those with <2 risk genotypes. Green tea drinking was suggested to have more than multiplicative interactions with alcohol consumption with an adjusted OR for interaction of 4.57 (95% CI = 1.62-12.89), and with higher multigenetic index with adjusted OR for interaction of 2.31 (95% CI = 0.88-6.03). The protective effect of green tea drinking was observed on the risk of stomach cancer and the possible effect modification by susceptibility genes was suggested.

Authors+Show Affiliations

Department of Epidemiology, Fudan University School of Public Health, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15856451

Citation

Mu, Li-Na, et al. "Green Tea Drinking and Multigenetic Index On the Risk of Stomach Cancer in a Chinese Population." International Journal of Cancer, vol. 116, no. 6, 2005, pp. 972-83.
Mu LN, Lu QY, Yu SZ, et al. Green tea drinking and multigenetic index on the risk of stomach cancer in a Chinese population. Int J Cancer. 2005;116(6):972-83.
Mu, L. N., Lu, Q. Y., Yu, S. Z., Jiang, Q. W., Cao, W., You, N. C., Setiawan, V. W., Zhou, X. F., Ding, B. G., Wang, R. H., Zhao, J., Cai, L., Rao, J. Y., Heber, D., & Zhang, Z. F. (2005). Green tea drinking and multigenetic index on the risk of stomach cancer in a Chinese population. International Journal of Cancer, 116(6), 972-83.
Mu LN, et al. Green Tea Drinking and Multigenetic Index On the Risk of Stomach Cancer in a Chinese Population. Int J Cancer. 2005 Oct 10;116(6):972-83. PubMed PMID: 15856451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Green tea drinking and multigenetic index on the risk of stomach cancer in a Chinese population. AU - Mu,Li-Na, AU - Lu,Qing-Yi, AU - Yu,Shun-Zhang, AU - Jiang,Qing-Wu, AU - Cao,Wei, AU - You,Nai-Chieh, AU - Setiawan,Veronica Wendy, AU - Zhou,Xue-Fu, AU - Ding,Bao-Guo, AU - Wang,Ru-Hong, AU - Zhao,Jinkou, AU - Cai,Lin, AU - Rao,Jian-Yu, AU - Heber,David, AU - Zhang,Zuo-Feng, PY - 2005/4/28/pubmed PY - 2005/10/20/medline PY - 2005/4/28/entrez SP - 972 EP - 83 JF - International journal of cancer JO - Int J Cancer VL - 116 IS - 6 N2 - The purpose of our study was to examine the roles of green tea drinking, other risk and protective factors, and polymorphism of susceptibility genes such as GSTM1, GSTT1, GSTP1, and p53 codon 72 and their possible joint effects on the risk of stomach cancer. A population-based case-control study was conducted in Taixing, China, including 206 newly diagnosed cases with stomach cancer and 415 healthy control subjects. Epidemiological data were collected by in-person interviews using a standard questionnaire. Polymorphisms of susceptibility genes were assayed by PCR-RFLP techniques. A multigenetic index was created by summing up the number of risk genotypes. The data were analyzed using the logistic regression model. A reverse association between green tea drinking and risk of stomach cancer was observed with an adjusted odds ratio (OR) of 0.59 (95% confidence interval [CI] = 0.34-1.01). Dose-response relationship was shown (p-trend < 0.05). A higher score on the multigenetic index was associated with increased risk of stomach cancer with an adjusted OR of 2.21 (95% CI = 1.02-4.79) for those with at least 3 risk genotypes compared to those with <2 risk genotypes. Green tea drinking was suggested to have more than multiplicative interactions with alcohol consumption with an adjusted OR for interaction of 4.57 (95% CI = 1.62-12.89), and with higher multigenetic index with adjusted OR for interaction of 2.31 (95% CI = 0.88-6.03). The protective effect of green tea drinking was observed on the risk of stomach cancer and the possible effect modification by susceptibility genes was suggested. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/15856451/Green_tea_drinking_and_multigenetic_index_on_the_risk_of_stomach_cancer_in_a_Chinese_population_ L2 - https://doi.org/10.1002/ijc.21137 DB - PRIME DP - Unbound Medicine ER -