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Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample.
Psychol Med 2005; 35(4):529-38PM

Abstract

BACKGROUND

Case control studies have supported a relationship between low folic acid and vitamin B112 and high homocysteine levels as possible predictors of depression. The results from epidemiological studies are mixed and largely from elderly populations.

METHOD

A random subsample of 412 persons aged 60-64 years from a larger community sample underwent psychiatric and physical assessments, and brain MRI scans. Subjects were assessed using the PRIME-MD Patient Health Questionnaire for syndromal depression and severity of depressive symptoms. Blood measures included serum folic acid, vitamin B12, homocysteine and creatinine levels, and total antioxidant capacity. MRI scans were quantified for brain atrophy, subcortical atrophy, and periventricular and deep white-matter hyperintensity on T2-weighted imaging.

RESULTS

Being in the lowest quartile of homocysteine was associated with fewer depressive symptoms, after adjusting for sex, physical health, smoking, creatinine, folic acid and B12 levels. Being in the lowest quartile of folic acid was associated with increased depressive symptoms, after adjusting for confounding factors, but adjustment for homocysteine reduced the incidence rate ratio for folic acid to a marginal level. Vitamin B12 levels did not have a significant association with depressive symptoms. While white-matter hyperintensities had significant correlations with both homocysteine and depressive symptoms, the brain measures and total antioxidant capacity did not emerge as significant mediating variables.

CONCLUSIONS

Low folic acid and high homocysteine, but not low vitamin B12 levels, are correlates of depressive symptoms in community-dwelling middle-aged individuals. The effects of folic acid and homocysteine are overlapping but distinct.

Authors+Show Affiliations

School of Psychiatry, University of New South Wales, Sydney, Australia. p.sachdev@unsw.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15856723

Citation

Sachdev, Perminder S., et al. "Relationship of Homocysteine, Folic Acid and Vitamin B12 With Depression in a Middle-aged Community Sample." Psychological Medicine, vol. 35, no. 4, 2005, pp. 529-38.
Sachdev PS, Parslow RA, Lux O, et al. Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample. Psychol Med. 2005;35(4):529-38.
Sachdev, P. S., Parslow, R. A., Lux, O., Salonikas, C., Wen, W., Naidoo, D., ... Jorm, A. F. (2005). Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample. Psychological Medicine, 35(4), pp. 529-38.
Sachdev PS, et al. Relationship of Homocysteine, Folic Acid and Vitamin B12 With Depression in a Middle-aged Community Sample. Psychol Med. 2005;35(4):529-38. PubMed PMID: 15856723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample. AU - Sachdev,Perminder S, AU - Parslow,Ruth A, AU - Lux,Ora, AU - Salonikas,Chris, AU - Wen,Wei, AU - Naidoo,Daya, AU - Christensen,Helen, AU - Jorm,Anthony F, PY - 2005/4/29/pubmed PY - 2005/8/24/medline PY - 2005/4/29/entrez SP - 529 EP - 38 JF - Psychological medicine JO - Psychol Med VL - 35 IS - 4 N2 - BACKGROUND: Case control studies have supported a relationship between low folic acid and vitamin B112 and high homocysteine levels as possible predictors of depression. The results from epidemiological studies are mixed and largely from elderly populations. METHOD: A random subsample of 412 persons aged 60-64 years from a larger community sample underwent psychiatric and physical assessments, and brain MRI scans. Subjects were assessed using the PRIME-MD Patient Health Questionnaire for syndromal depression and severity of depressive symptoms. Blood measures included serum folic acid, vitamin B12, homocysteine and creatinine levels, and total antioxidant capacity. MRI scans were quantified for brain atrophy, subcortical atrophy, and periventricular and deep white-matter hyperintensity on T2-weighted imaging. RESULTS: Being in the lowest quartile of homocysteine was associated with fewer depressive symptoms, after adjusting for sex, physical health, smoking, creatinine, folic acid and B12 levels. Being in the lowest quartile of folic acid was associated with increased depressive symptoms, after adjusting for confounding factors, but adjustment for homocysteine reduced the incidence rate ratio for folic acid to a marginal level. Vitamin B12 levels did not have a significant association with depressive symptoms. While white-matter hyperintensities had significant correlations with both homocysteine and depressive symptoms, the brain measures and total antioxidant capacity did not emerge as significant mediating variables. CONCLUSIONS: Low folic acid and high homocysteine, but not low vitamin B12 levels, are correlates of depressive symptoms in community-dwelling middle-aged individuals. The effects of folic acid and homocysteine are overlapping but distinct. SN - 0033-2917 UR - https://www.unboundmedicine.com/medline/citation/15856723/Relationship_of_homocysteine_folic_acid_and_vitamin_B12_with_depression_in_a_middle_aged_community_sample_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15856723.ui DB - PRIME DP - Unbound Medicine ER -