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[Effects of various contraceptives on laboratory parameters in diagnosis of thyroid gland function with special reference to the free hormones FT4 and FT3].
Z Gesamte Inn Med. 1992 Feb; 47(2):58-64.ZG

Abstract

The effect of different oral contraceptives with an estrogen content of 30-50 micrograms ethinyloestradiol on thyroid hormones and the binding protein TBG was investigated and quantified for 200 women. The sera of 220 normal persons were analysed to get normal values for T3, T4, FT4, Ft3, TBG and TSH. Under the influence of antiovulatory hormone treatment the thyroxin binding globulin increased to values above 32 mg/l in 65% of all euthyroid women. The median for T4 changed from 97 to 120 nmol/l, respectively from 2.3 to 2.8 nmol/l for T3. We think the combination of TSH, FT4 and T3 to be the best analytical tool for differential diagnosis of hyperthyreose. The FT4 level was nearly independent of variations in TBG concentration, so we can accept the normal range from 10-28 pmol/l for patients with contraceptives as well. In 16% of these euthyroid women the T3 level proved to be in the hyperthyroid range with values above 3.6 nmol/l. The FT3 determination is stronger influenced by protein changes caused by oestrogens than FT4 and should not be accepted as a favourite parameter for patients with oral contraceptives.

Authors+Show Affiliations

Abteilung für Nuklearmedizin, Klinik für Radiologie, Universität Leipzig.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

1585690

Citation

Sorger, D, et al. "[Effects of Various Contraceptives On Laboratory Parameters in Diagnosis of Thyroid Gland Function With Special Reference to the Free Hormones FT4 and FT3]." Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete, vol. 47, no. 2, 1992, pp. 58-64.
Sorger D, Schenk S, Schneider G. [Effects of various contraceptives on laboratory parameters in diagnosis of thyroid gland function with special reference to the free hormones FT4 and FT3]. Z Gesamte Inn Med. 1992;47(2):58-64.
Sorger, D., Schenk, S., & Schneider, G. (1992). [Effects of various contraceptives on laboratory parameters in diagnosis of thyroid gland function with special reference to the free hormones FT4 and FT3]. Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete, 47(2), 58-64.
Sorger D, Schenk S, Schneider G. [Effects of Various Contraceptives On Laboratory Parameters in Diagnosis of Thyroid Gland Function With Special Reference to the Free Hormones FT4 and FT3]. Z Gesamte Inn Med. 1992;47(2):58-64. PubMed PMID: 1585690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of various contraceptives on laboratory parameters in diagnosis of thyroid gland function with special reference to the free hormones FT4 and FT3]. AU - Sorger,D, AU - Schenk,S, AU - Schneider,G, PY - 1992/2/1/pubmed PY - 1992/2/1/medline PY - 1992/2/1/entrez KW - Biology KW - Contraception KW - Contraceptive Methods KW - Endocrine Effects KW - Endocrine System KW - Family Planning KW - Hormones KW - Measurement KW - Oral Contraceptives KW - Physiology KW - Research Methodology KW - Research Report KW - Thyroid Effects SP - 58 EP - 64 JF - Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete JO - Z Gesamte Inn Med VL - 47 IS - 2 N2 - The effect of different oral contraceptives with an estrogen content of 30-50 micrograms ethinyloestradiol on thyroid hormones and the binding protein TBG was investigated and quantified for 200 women. The sera of 220 normal persons were analysed to get normal values for T3, T4, FT4, Ft3, TBG and TSH. Under the influence of antiovulatory hormone treatment the thyroxin binding globulin increased to values above 32 mg/l in 65% of all euthyroid women. The median for T4 changed from 97 to 120 nmol/l, respectively from 2.3 to 2.8 nmol/l for T3. We think the combination of TSH, FT4 and T3 to be the best analytical tool for differential diagnosis of hyperthyreose. The FT4 level was nearly independent of variations in TBG concentration, so we can accept the normal range from 10-28 pmol/l for patients with contraceptives as well. In 16% of these euthyroid women the T3 level proved to be in the hyperthyroid range with values above 3.6 nmol/l. The FT3 determination is stronger influenced by protein changes caused by oestrogens than FT4 and should not be accepted as a favourite parameter for patients with oral contraceptives. SN - 0044-2542 UR - https://www.unboundmedicine.com/medline/citation/1585690/[Effects_of_various_contraceptives_on_laboratory_parameters_in_diagnosis_of_thyroid_gland_function_with_special_reference_to_the_free_hormones_FT4_and_FT3]_ L2 - https://medlineplus.gov/hyperthyroidism.html DB - PRIME DP - Unbound Medicine ER -