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Influence of cardiorespiratory fitness on the association between C-reactive protein and metabolic syndrome prevalence in racially diverse women.
J Womens Health (Larchmt). 2005 Apr; 14(3):233-9.JW

Abstract

BACKGROUND

Metabolic syndrome and C-reactive protein (CRP) are independent predictors of cardiovascular disease (CVD) among women. The extent to which cardiorespiratory fitness influences the relationship between CRP and metabolic syndrome is unknown.

METHODS AND RESULTS

Cross-sectional associations among fitness, CRP, and metabolic syndrome were examined in 135 African American, Native American, and Caucasian women (55 +/- 11 years, 28 +/- 6 kg/m2). Fitness was quantified with a symptom-limited maximal treadmill exercise test. Plasma CRP concentrations were determined with the Dade-Behring high-sensitivity immunoassay. Metabolic syndrome was defined according to NCEP-ATP III. Metabolic syndrome, CRP, and fitness varied (p < 0.05) by race. Race-adjusted CRP values were directly associated (p < 0.05) with each metabolic syndrome component. After adjusting for age and race, the relative odds of metabolic syndrome was 3.6 (95% CI = 1.5 - 8.4) in women with elevated (> 2.0 mg/L) vs. low CRP. Adjustment for smoking, hormone therapy, body mass index (BMI), and HOMA insulin resistance did not eliminate this association (p < 0.05). The association between CRP and the metabolic syndrome was no longer significant (OR = 1.3, 95% CI = 0.9 - 5.9, p = 0.59) after adjustment for fitness.

CONCLUSIONS

Higher cardiorespiratory fitness may be an important consideration in the milieu of vascular inflammation and metabolic syndrome.

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Authors+Show Affiliations

LaMonte MJ
The Cooper Institute, Dallas, Texas 75230, USA. mlamonte@cooperinst.org
Ainsworth BE
No affiliation info available
Durstine JL
No affiliation info available

MeSH

AdultAfrican AmericansBody Mass IndexC-Reactive ProteinCardiovascular DiseasesCardiovascular SystemConfidence IntervalsEthnicityFemaleHumansImmunoassayIndians, North AmericanMetabolic SyndromeMiddle AgedOdds RatioPhysical FitnessPrevalenceRespiratory SystemWhites

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15857269

Citation

LaMonte, Michael J., et al. "Influence of Cardiorespiratory Fitness On the Association Between C-reactive Protein and Metabolic Syndrome Prevalence in Racially Diverse Women." Journal of Women's Health (2002), vol. 14, no. 3, 2005, pp. 233-9.
LaMonte MJ, Ainsworth BE, Durstine JL. Influence of cardiorespiratory fitness on the association between C-reactive protein and metabolic syndrome prevalence in racially diverse women. J Womens Health (Larchmt). 2005;14(3):233-9.
LaMonte, M. J., Ainsworth, B. E., & Durstine, J. L. (2005). Influence of cardiorespiratory fitness on the association between C-reactive protein and metabolic syndrome prevalence in racially diverse women. Journal of Women's Health (2002), 14(3), 233-9.
LaMonte MJ, Ainsworth BE, Durstine JL. Influence of Cardiorespiratory Fitness On the Association Between C-reactive Protein and Metabolic Syndrome Prevalence in Racially Diverse Women. J Womens Health (Larchmt). 2005;14(3):233-9. PubMed PMID: 15857269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of cardiorespiratory fitness on the association between C-reactive protein and metabolic syndrome prevalence in racially diverse women. AU - LaMonte,Michael J, AU - Ainsworth,Barbara E, AU - Durstine,J Larry, PY - 2005/4/29/pubmed PY - 2005/7/20/medline PY - 2005/4/29/entrez SP - 233 EP - 9 JF - Journal of women's health (2002) JO - J Womens Health (Larchmt) VL - 14 IS - 3 N2 - BACKGROUND: Metabolic syndrome and C-reactive protein (CRP) are independent predictors of cardiovascular disease (CVD) among women. The extent to which cardiorespiratory fitness influences the relationship between CRP and metabolic syndrome is unknown. METHODS AND RESULTS: Cross-sectional associations among fitness, CRP, and metabolic syndrome were examined in 135 African American, Native American, and Caucasian women (55 +/- 11 years, 28 +/- 6 kg/m2). Fitness was quantified with a symptom-limited maximal treadmill exercise test. Plasma CRP concentrations were determined with the Dade-Behring high-sensitivity immunoassay. Metabolic syndrome was defined according to NCEP-ATP III. Metabolic syndrome, CRP, and fitness varied (p < 0.05) by race. Race-adjusted CRP values were directly associated (p < 0.05) with each metabolic syndrome component. After adjusting for age and race, the relative odds of metabolic syndrome was 3.6 (95% CI = 1.5 - 8.4) in women with elevated (> 2.0 mg/L) vs. low CRP. Adjustment for smoking, hormone therapy, body mass index (BMI), and HOMA insulin resistance did not eliminate this association (p < 0.05). The association between CRP and the metabolic syndrome was no longer significant (OR = 1.3, 95% CI = 0.9 - 5.9, p = 0.59) after adjustment for fitness. CONCLUSIONS: Higher cardiorespiratory fitness may be an important consideration in the milieu of vascular inflammation and metabolic syndrome. SN - 1540-9996 UR - https://www.unboundmedicine.com/medline/citation/15857269/Influence_of_cardiorespiratory_fitness_on_the_association_between_C_reactive_protein_and_metabolic_syndrome_prevalence_in_racially_diverse_women_ L2 - https://www.liebertpub.com/doi/10.1089/jwh.2005.14.233?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -