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Subepidermal blistering disease with autoantibodies to both the p200 autoantigen and the alpha3 chain of laminin 5.
J Am Acad Dermatol. 2005 May; 52(5 Suppl 1):S90-2.JA

Abstract

Anti-p200 pemphigoid and anti-laminin 5 mucous membrane pemphigoid are two distinct autoimmune blistering skin diseases. Patients with anti-p200 pemphigoid demonstrate circulating autoantibodies to an unknown 200-kd acidic noncollagenous glycoprotein of the lower lamina lucida, whereas anti-laminin 5 mucous membrane pemphigoid is characterized by an autoimmune response against the major basement membrane adhesion molecule laminin 5. In this report, we describe a patient who developed a recurrent nonscarring blistering eruption, affecting both skin and mucous membranes. Immunoblotting of dermal extracts and extracellular matrix of cultured keratinocytes revealed circulating autoantibodies directed to the p200 antigen and the alpha3 chain of laminin 5, respectively. The unusual clinical and immunologic profile of this case suggests that molecular specificity of circulating autoantibodies affects the clinical presentation of autoimmune subepidermal blistering skin diseases.

Authors+Show Affiliations

Department of Dermatology, University of Lübeck, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15858518

Citation

Shimanovich, Iakov, et al. "Subepidermal Blistering Disease With Autoantibodies to Both the P200 Autoantigen and the Alpha3 Chain of Laminin 5." Journal of the American Academy of Dermatology, vol. 52, no. 5 Suppl 1, 2005, pp. S90-2.
Shimanovich I, Petersen EE, Weyers W, et al. Subepidermal blistering disease with autoantibodies to both the p200 autoantigen and the alpha3 chain of laminin 5. J Am Acad Dermatol. 2005;52(5 Suppl 1):S90-2.
Shimanovich, I., Petersen, E. E., Weyers, W., Sitaru, C., & Zillikens, D. (2005). Subepidermal blistering disease with autoantibodies to both the p200 autoantigen and the alpha3 chain of laminin 5. Journal of the American Academy of Dermatology, 52(5 Suppl 1), S90-2.
Shimanovich I, et al. Subepidermal Blistering Disease With Autoantibodies to Both the P200 Autoantigen and the Alpha3 Chain of Laminin 5. J Am Acad Dermatol. 2005;52(5 Suppl 1):S90-2. PubMed PMID: 15858518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subepidermal blistering disease with autoantibodies to both the p200 autoantigen and the alpha3 chain of laminin 5. AU - Shimanovich,Iakov, AU - Petersen,Eiko E, AU - Weyers,Wolfgang, AU - Sitaru,Cassian, AU - Zillikens,Detlef, PY - 2005/4/29/pubmed PY - 2006/3/8/medline PY - 2005/4/29/entrez SP - S90 EP - 2 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 52 IS - 5 Suppl 1 N2 - Anti-p200 pemphigoid and anti-laminin 5 mucous membrane pemphigoid are two distinct autoimmune blistering skin diseases. Patients with anti-p200 pemphigoid demonstrate circulating autoantibodies to an unknown 200-kd acidic noncollagenous glycoprotein of the lower lamina lucida, whereas anti-laminin 5 mucous membrane pemphigoid is characterized by an autoimmune response against the major basement membrane adhesion molecule laminin 5. In this report, we describe a patient who developed a recurrent nonscarring blistering eruption, affecting both skin and mucous membranes. Immunoblotting of dermal extracts and extracellular matrix of cultured keratinocytes revealed circulating autoantibodies directed to the p200 antigen and the alpha3 chain of laminin 5, respectively. The unusual clinical and immunologic profile of this case suggests that molecular specificity of circulating autoantibodies affects the clinical presentation of autoimmune subepidermal blistering skin diseases. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/15858518/Subepidermal_blistering_disease_with_autoantibodies_to_both_the_p200_autoantigen_and_the_alpha3_chain_of_laminin_5_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190962204019486 DB - PRIME DP - Unbound Medicine ER -