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Factors predicting the development of metabolic syndrome and type II diabetes against a background of hypertension.
Eur J Clin Invest. 2005 May; 35(5):324-9.EJ

Abstract

BACKGROUND

The metabolic syndrome (MetS), predicting coronary heart disease (CHD), is a compound of risk factors including diabetes, obesity and hypertension. The relationship between the development of MetS, diabetes and CHD in patients with established hypertension is unclear. We hypothesized that patients with hypertension developing MetS are at increased risk of type II diabetes and CHD compared with patients who do not develop MetS.

MATERIALS AND METHODS

We prospectively studied 284 patients (100 with existing/established MetS) with hypertension but without diabetes and CHD over 4 years. MetS and diabetes were diagnosed by the modified NCEP and ADA criteria, and CHD risk by the Framingham risk equation; all patients had annual fasting blood sampling.

RESULTS

Over 4 years of follow up, 75 of the 184 patients (41%) initially free of MetS at baseline subsequently fulfilled the criteria for MetS. These patients (i.e. 'developing MetS') had higher baseline BMI, triglycerides and lower HDL cholesterol, with a higher calculated CHD risk (all P <or= 0.001) than those who did not develop MetS. The 4-year odds ratios of developing diabetes in the patients with established MetS (23%) and the patients developing MetS (13.3%) vs. the patients not developing MetS (3.7%, P < 0.001) were 7.8 (95% CI: 2.6-23.5) and 4.0 (95% CI: 1.2-13.4), respectively.

CONCLUSIONS

Patients with hypertension developing MetS have an increased CHD risk and risk of developing type II diabetes even before fulfilling the criteria for MetS, and the former is comparable to patients with established MetS. These data suggest a high-risk phase not adequately identified by current diagnostic thresholds for MetS.

Authors+Show Affiliations

Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15860044

Citation

Lim, H S., et al. "Factors Predicting the Development of Metabolic Syndrome and Type II Diabetes Against a Background of Hypertension." European Journal of Clinical Investigation, vol. 35, no. 5, 2005, pp. 324-9.
Lim HS, Lip GY, Beevers DG, et al. Factors predicting the development of metabolic syndrome and type II diabetes against a background of hypertension. Eur J Clin Invest. 2005;35(5):324-9.
Lim, H. S., Lip, G. Y., Beevers, D. G., & Blann, A. D. (2005). Factors predicting the development of metabolic syndrome and type II diabetes against a background of hypertension. European Journal of Clinical Investigation, 35(5), 324-9.
Lim HS, et al. Factors Predicting the Development of Metabolic Syndrome and Type II Diabetes Against a Background of Hypertension. Eur J Clin Invest. 2005;35(5):324-9. PubMed PMID: 15860044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors predicting the development of metabolic syndrome and type II diabetes against a background of hypertension. AU - Lim,H S, AU - Lip,G Y H, AU - Beevers,D G, AU - Blann,A D, PY - 2005/4/30/pubmed PY - 2005/8/30/medline PY - 2005/4/30/entrez SP - 324 EP - 9 JF - European journal of clinical investigation JO - Eur J Clin Invest VL - 35 IS - 5 N2 - BACKGROUND: The metabolic syndrome (MetS), predicting coronary heart disease (CHD), is a compound of risk factors including diabetes, obesity and hypertension. The relationship between the development of MetS, diabetes and CHD in patients with established hypertension is unclear. We hypothesized that patients with hypertension developing MetS are at increased risk of type II diabetes and CHD compared with patients who do not develop MetS. MATERIALS AND METHODS: We prospectively studied 284 patients (100 with existing/established MetS) with hypertension but without diabetes and CHD over 4 years. MetS and diabetes were diagnosed by the modified NCEP and ADA criteria, and CHD risk by the Framingham risk equation; all patients had annual fasting blood sampling. RESULTS: Over 4 years of follow up, 75 of the 184 patients (41%) initially free of MetS at baseline subsequently fulfilled the criteria for MetS. These patients (i.e. 'developing MetS') had higher baseline BMI, triglycerides and lower HDL cholesterol, with a higher calculated CHD risk (all P <or= 0.001) than those who did not develop MetS. The 4-year odds ratios of developing diabetes in the patients with established MetS (23%) and the patients developing MetS (13.3%) vs. the patients not developing MetS (3.7%, P < 0.001) were 7.8 (95% CI: 2.6-23.5) and 4.0 (95% CI: 1.2-13.4), respectively. CONCLUSIONS: Patients with hypertension developing MetS have an increased CHD risk and risk of developing type II diabetes even before fulfilling the criteria for MetS, and the former is comparable to patients with established MetS. These data suggest a high-risk phase not adequately identified by current diagnostic thresholds for MetS. SN - 0014-2972 UR - https://www.unboundmedicine.com/medline/citation/15860044/Factors_predicting_the_development_of_metabolic_syndrome_and_type_II_diabetes_against_a_background_of_hypertension_ L2 - https://doi.org/10.1111/j.1365-2362.2005.01495.x DB - PRIME DP - Unbound Medicine ER -