Tags

Type your tag names separated by a space and hit enter

The use of acetazolamide in idiopathic intracranial hypertension during pregnancy.
Am J Ophthalmol. 2005 May; 139(5):855-9.AJ

Abstract

PURPOSE

To describe the pregnancy outcomes after the use of acetazolamide in pregnant patients with idiopathic intracranial hypertension (IIH).

DESIGN

Observational case series.

METHODS

setting: Two tertiary care academic neuro-ophthalmology units. patient population: Patients with IIH treated with acetazolamide. observation procedure: Documentation of pregnancy outcome. main outcome measures: Normal pregnancy, fetal loss, or congenital malformation.

RESULTS

Twelve patients were treated with acetazolamide for IIH during pregnancy, and there were no adverse pregnancy outcomes. A critical review of the English language literature on the subject failed to demonstrate any convincing evidence for any adverse effect on pregnancy for acetazolamide.

CONCLUSIONS

Acetazolamide at high doses may produce birth defects in animals, but there is little clinical or experimental evidence to support any adverse effect of the drug on pregnancy outcomes in humans. If the clinical situation warrants the use of acetazolamide in IIH, then the drug probably can be offered after appropriate informed consent.

Authors+Show Affiliations

Department of Ophthalmology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, PFP, Iowa City, IA 52242, USA. andrew-lee@uiowa.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15860291

Citation

Lee, Andrew G., et al. "The Use of Acetazolamide in Idiopathic Intracranial Hypertension During Pregnancy." American Journal of Ophthalmology, vol. 139, no. 5, 2005, pp. 855-9.
Lee AG, Pless M, Falardeau J, et al. The use of acetazolamide in idiopathic intracranial hypertension during pregnancy. Am J Ophthalmol. 2005;139(5):855-9.
Lee, A. G., Pless, M., Falardeau, J., Capozzoli, T., Wall, M., & Kardon, R. H. (2005). The use of acetazolamide in idiopathic intracranial hypertension during pregnancy. American Journal of Ophthalmology, 139(5), 855-9.
Lee AG, et al. The Use of Acetazolamide in Idiopathic Intracranial Hypertension During Pregnancy. Am J Ophthalmol. 2005;139(5):855-9. PubMed PMID: 15860291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The use of acetazolamide in idiopathic intracranial hypertension during pregnancy. AU - Lee,Andrew G, AU - Pless,Misha, AU - Falardeau,Julie, AU - Capozzoli,Tammy, AU - Wall,Michael, AU - Kardon,Randy H, PY - 2004/12/28/accepted PY - 2005/4/30/pubmed PY - 2005/6/9/medline PY - 2005/4/30/entrez SP - 855 EP - 9 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 139 IS - 5 N2 - PURPOSE: To describe the pregnancy outcomes after the use of acetazolamide in pregnant patients with idiopathic intracranial hypertension (IIH). DESIGN: Observational case series. METHODS: setting: Two tertiary care academic neuro-ophthalmology units. patient population: Patients with IIH treated with acetazolamide. observation procedure: Documentation of pregnancy outcome. main outcome measures: Normal pregnancy, fetal loss, or congenital malformation. RESULTS: Twelve patients were treated with acetazolamide for IIH during pregnancy, and there were no adverse pregnancy outcomes. A critical review of the English language literature on the subject failed to demonstrate any convincing evidence for any adverse effect on pregnancy for acetazolamide. CONCLUSIONS: Acetazolamide at high doses may produce birth defects in animals, but there is little clinical or experimental evidence to support any adverse effect of the drug on pregnancy outcomes in humans. If the clinical situation warrants the use of acetazolamide in IIH, then the drug probably can be offered after appropriate informed consent. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/15860291/The_use_of_acetazolamide_in_idiopathic_intracranial_hypertension_during_pregnancy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(04)01634-4 DB - PRIME DP - Unbound Medicine ER -