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Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer.
Nutr Cancer 2005; 51(2):162-9NC

Abstract

Although many dietary studies have focused on breast cancer risk, few have examined dietary influence on tumor characteristics such as estrogen receptor (ER) status. Because phytoestrogens may modulate hormone levels and ER expression, we analyzed ER status and phytoestrogen intake in a case-case study of 124 premenopausal breast cancer patients. We assessed intake with a food-frequency questionnaire and obtained ER status from medical records. Rather than focusing on risk, we evaluated whether low intakes were more strongly associated with ER-negative tumors than with ER-positive disease. In logistic regression adjusting for potential confounders, threefold greater risks of ER-negative tumors relative to ER-positive tumors were associated with low intake of the isoflavones genistein (odds ratio, OR=3.50; 95% confidence interval, CI=1.43-8.58) and daidzein (OR=3.10; 95% CI=1.31-7.30). Low intake of the flavonoid kaempferol (OR=0.36; 95% CI=0.16-0.83), the trace element boron (OR=0.33; 95% CI=0.13-0.83), and the phytosterol beta-sitosterol (OR=0.42; 95% CI=0.18-0.98) were associated with decreased risk of ER-negative tumors relative to ER-positive disease. Other phytoestrogens were not significantly associated with ER status. Thus, in premenopausal patients, some phytoestrogens may affect breast carcinogenesis by influencing ER status. Such findings suggest new directions for mechanistic research on dietary factors in breast carcinogenesis that may have relevance for prevention and clinical treatment.

Authors+Show Affiliations

Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15860438

Citation

Touillaud, Marina S., et al. "Effect of Dietary Intake of Phytoestrogens On Estrogen Receptor Status in Premenopausal Women With Breast Cancer." Nutrition and Cancer, vol. 51, no. 2, 2005, pp. 162-9.
Touillaud MS, Pillow PC, Jakovljevic J, et al. Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer. Nutr Cancer. 2005;51(2):162-9.
Touillaud, M. S., Pillow, P. C., Jakovljevic, J., Bondy, M. L., Singletary, S. E., Li, D., & Chang, S. (2005). Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer. Nutrition and Cancer, 51(2), pp. 162-9.
Touillaud MS, et al. Effect of Dietary Intake of Phytoestrogens On Estrogen Receptor Status in Premenopausal Women With Breast Cancer. Nutr Cancer. 2005;51(2):162-9. PubMed PMID: 15860438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer. AU - Touillaud,Marina S, AU - Pillow,Patricia C, AU - Jakovljevic,Jelena, AU - Bondy,Melissa L, AU - Singletary,S Eva, AU - Li,Donghui, AU - Chang,Shine, PY - 2005/4/30/pubmed PY - 2005/10/28/medline PY - 2005/4/30/entrez SP - 162 EP - 9 JF - Nutrition and cancer JO - Nutr Cancer VL - 51 IS - 2 N2 - Although many dietary studies have focused on breast cancer risk, few have examined dietary influence on tumor characteristics such as estrogen receptor (ER) status. Because phytoestrogens may modulate hormone levels and ER expression, we analyzed ER status and phytoestrogen intake in a case-case study of 124 premenopausal breast cancer patients. We assessed intake with a food-frequency questionnaire and obtained ER status from medical records. Rather than focusing on risk, we evaluated whether low intakes were more strongly associated with ER-negative tumors than with ER-positive disease. In logistic regression adjusting for potential confounders, threefold greater risks of ER-negative tumors relative to ER-positive tumors were associated with low intake of the isoflavones genistein (odds ratio, OR=3.50; 95% confidence interval, CI=1.43-8.58) and daidzein (OR=3.10; 95% CI=1.31-7.30). Low intake of the flavonoid kaempferol (OR=0.36; 95% CI=0.16-0.83), the trace element boron (OR=0.33; 95% CI=0.13-0.83), and the phytosterol beta-sitosterol (OR=0.42; 95% CI=0.18-0.98) were associated with decreased risk of ER-negative tumors relative to ER-positive disease. Other phytoestrogens were not significantly associated with ER status. Thus, in premenopausal patients, some phytoestrogens may affect breast carcinogenesis by influencing ER status. Such findings suggest new directions for mechanistic research on dietary factors in breast carcinogenesis that may have relevance for prevention and clinical treatment. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/15860438/Effect_of_dietary_intake_of_phytoestrogens_on_estrogen_receptor_status_in_premenopausal_women_with_breast_cancer_ L2 - http://www.tandfonline.com/doi/full/10.1207/s15327914nc5102_6 DB - PRIME DP - Unbound Medicine ER -