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Breast fine-needle aspirates with scant cellularity are clinically useful.
Am J Surg. 2005 May; 189(5):621-5; discussion 625-6.AJ

Abstract

INTRODUCTION

Fine-needle aspirates (FNAs) with scant cellularity are considered inadequate by current cytopathology standards. We hypothesized that such aspirates are clinically useful.

METHODS

A 10-year database of palpable breast lumps evaluated by FNA-based triple test (TT; FNA, breast imaging studies, and clinical breast examination) and triple test scores (TTSs; 3-9) was examined to identify FNAs with scant cellularity but without evidence of malignancy (negative SC-FNAs). These FNAs were correlated with the occurrence of any subsequent cancers (false-negative SC-FNAs) and with TTSs.

RESULTS

Among a total of 324 negative SC-FNAs, 9 cancers were subsequently found at sampled sites. Seven were associated with a suspicious or malignant TTS (scores of 5 or greater) and therefore still correctly diagnosed as malignant or suspicious for malignancy. The remaining two cancers were missed by both SC-FNA and TTS (false-negative rate for TTS of 0.6%); both had scores of 4 because of suspicious imaging.

CONCLUSIONS

Scantly cellular but negative FNAs are useful (can avoid unnecessary invasive breast biopsy) in the evaluation of palpable breast masses, especially when interpreted in the context of the TT and TTS.

Authors+Show Affiliations

Department of Surgery, Division of Surgical Oncology, L-223A, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA. vettoj@ohsu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15862508

Citation

Vetto, John T., et al. "Breast Fine-needle Aspirates With Scant Cellularity Are Clinically Useful." American Journal of Surgery, vol. 189, no. 5, 2005, pp. 621-5; discussion 625-6.
Vetto JT, Pommier RF, Shih RL, et al. Breast fine-needle aspirates with scant cellularity are clinically useful. Am J Surg. 2005;189(5):621-5; discussion 625-6.
Vetto, J. T., Pommier, R. F., Shih, R. L., Campagna, J., Robbins, D., & Schmidt, W. A. (2005). Breast fine-needle aspirates with scant cellularity are clinically useful. American Journal of Surgery, 189(5), 621-5; discussion 625-6.
Vetto JT, et al. Breast Fine-needle Aspirates With Scant Cellularity Are Clinically Useful. Am J Surg. 2005;189(5):621-5; discussion 625-6. PubMed PMID: 15862508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast fine-needle aspirates with scant cellularity are clinically useful. AU - Vetto,John T, AU - Pommier,Rodney F, AU - Shih,Richard L, AU - Campagna,Jess, AU - Robbins,Debra, AU - Schmidt,Waldemar A, PY - 2004/12/23/received PY - 2005/01/25/revised PY - 2005/01/25/accepted PY - 2005/5/3/pubmed PY - 2005/6/14/medline PY - 2005/5/3/entrez SP - 621-5; discussion 625-6 JF - American journal of surgery JO - Am J Surg VL - 189 IS - 5 N2 - INTRODUCTION: Fine-needle aspirates (FNAs) with scant cellularity are considered inadequate by current cytopathology standards. We hypothesized that such aspirates are clinically useful. METHODS: A 10-year database of palpable breast lumps evaluated by FNA-based triple test (TT; FNA, breast imaging studies, and clinical breast examination) and triple test scores (TTSs; 3-9) was examined to identify FNAs with scant cellularity but without evidence of malignancy (negative SC-FNAs). These FNAs were correlated with the occurrence of any subsequent cancers (false-negative SC-FNAs) and with TTSs. RESULTS: Among a total of 324 negative SC-FNAs, 9 cancers were subsequently found at sampled sites. Seven were associated with a suspicious or malignant TTS (scores of 5 or greater) and therefore still correctly diagnosed as malignant or suspicious for malignancy. The remaining two cancers were missed by both SC-FNA and TTS (false-negative rate for TTS of 0.6%); both had scores of 4 because of suspicious imaging. CONCLUSIONS: Scantly cellular but negative FNAs are useful (can avoid unnecessary invasive breast biopsy) in the evaluation of palpable breast masses, especially when interpreted in the context of the TT and TTS. SN - 0002-9610 UR - https://www.unboundmedicine.com/medline/citation/15862508/Breast_fine_needle_aspirates_with_scant_cellularity_are_clinically_useful_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9610(05)00171-6 DB - PRIME DP - Unbound Medicine ER -