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The pathogenesis of bloating and visible distension in irritable bowel syndrome.
Gastroenterol Clin North Am 2005; 34(2):257-69GC

Abstract

Abdominal bloating is a relevant, troublesome, and poorly understood clinical problem. Despite its clinical importance, bloating remains substantially ignored, without proper clinical classification, known pathophysiology, and effective treatment. It is not even clear to what extent the complaints of individual patients correlate with objective evidence of abdominal distension, and this uncertainly regarding the subjective or objective origin of the complaints further adds to confusion. This article proposed a framework for investigating bloating, considering key factors potentially involved in its pathophysiology: distorted sensation, physical abdominal expansion, and abdominal wall dystony. Some data indicate that patients complaining of bloating have impaired transit and tolerance of intestinal gas loads. The problem does not seem to be too much gas,however, but rather abnormal responses to gas. Furthermore, abnormal control of abdominal muscle activity in these patients may contribute to objective distension. Bloating, like many other abdominal symptoms,probably represents a heterogeneous condition produced by a combination of pathophysiological mechanisms that differ among individual patients,resulting in a polymorphic clinical presentation.

Authors+Show Affiliations

University Hospital Vall d'Hebron, Autonomous University of Barcelona, PG Vall d'Hebron S/N, Barcelona 08035, Spain. fernando.azpiroz@wol.esNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15862934

Citation

Azpiroz, Fernando, and Juan R. Malagelada. "The Pathogenesis of Bloating and Visible Distension in Irritable Bowel Syndrome." Gastroenterology Clinics of North America, vol. 34, no. 2, 2005, pp. 257-69.
Azpiroz F, Malagelada JR. The pathogenesis of bloating and visible distension in irritable bowel syndrome. Gastroenterol Clin North Am. 2005;34(2):257-69.
Azpiroz, F., & Malagelada, J. R. (2005). The pathogenesis of bloating and visible distension in irritable bowel syndrome. Gastroenterology Clinics of North America, 34(2), pp. 257-69.
Azpiroz F, Malagelada JR. The Pathogenesis of Bloating and Visible Distension in Irritable Bowel Syndrome. Gastroenterol Clin North Am. 2005;34(2):257-69. PubMed PMID: 15862934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The pathogenesis of bloating and visible distension in irritable bowel syndrome. AU - Azpiroz,Fernando, AU - Malagelada,Juan R, PY - 2005/5/3/pubmed PY - 2005/7/27/medline PY - 2005/5/3/entrez SP - 257 EP - 69 JF - Gastroenterology clinics of North America JO - Gastroenterol. Clin. North Am. VL - 34 IS - 2 N2 - Abdominal bloating is a relevant, troublesome, and poorly understood clinical problem. Despite its clinical importance, bloating remains substantially ignored, without proper clinical classification, known pathophysiology, and effective treatment. It is not even clear to what extent the complaints of individual patients correlate with objective evidence of abdominal distension, and this uncertainly regarding the subjective or objective origin of the complaints further adds to confusion. This article proposed a framework for investigating bloating, considering key factors potentially involved in its pathophysiology: distorted sensation, physical abdominal expansion, and abdominal wall dystony. Some data indicate that patients complaining of bloating have impaired transit and tolerance of intestinal gas loads. The problem does not seem to be too much gas,however, but rather abnormal responses to gas. Furthermore, abnormal control of abdominal muscle activity in these patients may contribute to objective distension. Bloating, like many other abdominal symptoms,probably represents a heterogeneous condition produced by a combination of pathophysiological mechanisms that differ among individual patients,resulting in a polymorphic clinical presentation. SN - 0889-8553 UR - https://www.unboundmedicine.com/medline/citation/15862934/The_pathogenesis_of_bloating_and_visible_distension_in_irritable_bowel_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-8553(05)00007-5 DB - PRIME DP - Unbound Medicine ER -