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Brain responses to visceral and somatic stimuli in irritable bowel syndrome: a central nervous system disorder?
Gastroenterol Clin North Am. 2005 Jun; 34(2):271-9.GC

Abstract

In healthy subjects, the brain regions most consistently activated in visceral and somatic pain are the key regions in the central pain matrix,including the mid/anterior insula, subregions of the ACC, PFC, thalamus,and in some cases, pontine regions such as the dorsal pons and PAG. Functional neuroimaging studies have demonstrated evidence of altered regional brain activation responses during visceral and somatic stimuli in IBS that have been associated with perceptual differences. Although perceptual studies have shown increased sensitivity to rectosigmoid distension in IBS, most somatic pain studies have demonstrated normal or decreased sensitivity compared with controls; however, a recent study showed increased sensitivity to thermal heat. Altered brain responses in IBS,particularly to visceral stimuli, include activation of regions concerned with attentional processes and response selection, corticolimbic regions concerned with emotional and autonomic responses to stimuli, and subcortical regions receiving cortical projections from the latter and afferent input from the soma and viscera. Altered activations of these regions also may be present in the absence of a noxious visceral stimulus. Changes in rCBF of some of these regions have been associated with treatment response in IBS. With regard to differences in cortical processing of visceral versus somatic stimuli in IBS, there have been only two studies. Greater activations of the dorsal ACC, thalamus, and PFC have been shown with visceral stimuli compared with somatic stimuli in IBS. A plausible hypothesis for the observations from brain imaging studies is that IBS patients demonstrate a compromised activation of pain inhibition circuits including those of the cortico-pontine circuit but increased activation of limbic and paralimbic circuits that may be related to pain facilitation.

Authors+Show Affiliations

Center for Neurovisceral Sciences & Women's Health, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90024, USA. linchang@ucla.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15862935

Citation

Chang, Lin. "Brain Responses to Visceral and Somatic Stimuli in Irritable Bowel Syndrome: a Central Nervous System Disorder?" Gastroenterology Clinics of North America, vol. 34, no. 2, 2005, pp. 271-9.
Chang L. Brain responses to visceral and somatic stimuli in irritable bowel syndrome: a central nervous system disorder? Gastroenterol Clin North Am. 2005;34(2):271-9.
Chang, L. (2005). Brain responses to visceral and somatic stimuli in irritable bowel syndrome: a central nervous system disorder? Gastroenterology Clinics of North America, 34(2), 271-9.
Chang L. Brain Responses to Visceral and Somatic Stimuli in Irritable Bowel Syndrome: a Central Nervous System Disorder. Gastroenterol Clin North Am. 2005;34(2):271-9. PubMed PMID: 15862935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain responses to visceral and somatic stimuli in irritable bowel syndrome: a central nervous system disorder? A1 - Chang,Lin, PY - 2005/5/3/pubmed PY - 2005/7/27/medline PY - 2005/5/3/entrez SP - 271 EP - 9 JF - Gastroenterology clinics of North America JO - Gastroenterol Clin North Am VL - 34 IS - 2 N2 - In healthy subjects, the brain regions most consistently activated in visceral and somatic pain are the key regions in the central pain matrix,including the mid/anterior insula, subregions of the ACC, PFC, thalamus,and in some cases, pontine regions such as the dorsal pons and PAG. Functional neuroimaging studies have demonstrated evidence of altered regional brain activation responses during visceral and somatic stimuli in IBS that have been associated with perceptual differences. Although perceptual studies have shown increased sensitivity to rectosigmoid distension in IBS, most somatic pain studies have demonstrated normal or decreased sensitivity compared with controls; however, a recent study showed increased sensitivity to thermal heat. Altered brain responses in IBS,particularly to visceral stimuli, include activation of regions concerned with attentional processes and response selection, corticolimbic regions concerned with emotional and autonomic responses to stimuli, and subcortical regions receiving cortical projections from the latter and afferent input from the soma and viscera. Altered activations of these regions also may be present in the absence of a noxious visceral stimulus. Changes in rCBF of some of these regions have been associated with treatment response in IBS. With regard to differences in cortical processing of visceral versus somatic stimuli in IBS, there have been only two studies. Greater activations of the dorsal ACC, thalamus, and PFC have been shown with visceral stimuli compared with somatic stimuli in IBS. A plausible hypothesis for the observations from brain imaging studies is that IBS patients demonstrate a compromised activation of pain inhibition circuits including those of the cortico-pontine circuit but increased activation of limbic and paralimbic circuits that may be related to pain facilitation. SN - 0889-8553 UR - https://www.unboundmedicine.com/medline/citation/15862935/Brain_responses_to_visceral_and_somatic_stimuli_in_irritable_bowel_syndrome:_a_central_nervous_system_disorder L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-8553(05)00004-X DB - PRIME DP - Unbound Medicine ER -