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Ibotenic acid lesions of the medial prefrontal cortex block the development and expression of 3,4-methylenedioxymethamphetamine-induced behavioral sensitization in rats.
Behav Brain Res. 2005 May 28; 160(2):304-11.BB

Abstract

There is ample evidence that plastic changes in the nervous system require the excitatory amino acid transmission. This appears to be also the case for psychostimulant-induced behavioral sensitization. More specifically the glutamatergic input from the medial prefrontal cortex (mPFC) to the VTA and the NAc appears to be involved in behavioral sensitization processes. However, dissociations regarding the role of the mPFC with respect to the development and expression of sensitization, as well as with respect to the psychostimulant being studied (amphetamine versus cocaine) appear to exist. The present study examined the role of the dorsal mPFC in the development and expression of 3,4-methylenedioxymethamphetamine (MDMA)-induced sensitization. Bilateral ibotenic acid or sham lesions of the dorsal mPFC were performed 7 days prior to or 4 days after a context-dependent sensitization-inducing regimen of MDMA (15 mg/kg i.p.) or saline. Rats were then challenged with MDMA (5 mg/kg i.p.) after 12 days of withdrawal. Ibotenic acid lesions did not affect the activating effects of MDMA, but prevented the development and expression of MDMA sensitization. Thus, the distance traveled during the development phase of sensitization increased in sham-lesioned rats but not in ibotenic-lesioned animals. Similarly, sham-lesioned rats showed a sensitized response when challenged with MDMA after the withdrawal period, an effect not observed in ibotenic-lesioned animals. These data reinforce the view that the dorsal mPFC is involved in psychostimulant sensitization and more specifically they indicate that the dorsal mPFC plays a key role in the development and expression of MDMA-induced behavioral sensitization.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, University of Navarra, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15863226

Citation

Ramos, María, et al. "Ibotenic Acid Lesions of the Medial Prefrontal Cortex Block the Development and Expression of 3,4-methylenedioxymethamphetamine-induced Behavioral Sensitization in Rats." Behavioural Brain Research, vol. 160, no. 2, 2005, pp. 304-11.
Ramos M, Goñi-Allo B, Aguirre N. Ibotenic acid lesions of the medial prefrontal cortex block the development and expression of 3,4-methylenedioxymethamphetamine-induced behavioral sensitization in rats. Behav Brain Res. 2005;160(2):304-11.
Ramos, M., Goñi-Allo, B., & Aguirre, N. (2005). Ibotenic acid lesions of the medial prefrontal cortex block the development and expression of 3,4-methylenedioxymethamphetamine-induced behavioral sensitization in rats. Behavioural Brain Research, 160(2), 304-11.
Ramos M, Goñi-Allo B, Aguirre N. Ibotenic Acid Lesions of the Medial Prefrontal Cortex Block the Development and Expression of 3,4-methylenedioxymethamphetamine-induced Behavioral Sensitization in Rats. Behav Brain Res. 2005 May 28;160(2):304-11. PubMed PMID: 15863226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ibotenic acid lesions of the medial prefrontal cortex block the development and expression of 3,4-methylenedioxymethamphetamine-induced behavioral sensitization in rats. AU - Ramos,María, AU - Goñi-Allo,Beatriz, AU - Aguirre,Norberto, PY - 2004/09/10/received PY - 2004/12/13/revised PY - 2004/12/16/accepted PY - 2005/5/3/pubmed PY - 2005/7/16/medline PY - 2005/5/3/entrez SP - 304 EP - 11 JF - Behavioural brain research JO - Behav. Brain Res. VL - 160 IS - 2 N2 - There is ample evidence that plastic changes in the nervous system require the excitatory amino acid transmission. This appears to be also the case for psychostimulant-induced behavioral sensitization. More specifically the glutamatergic input from the medial prefrontal cortex (mPFC) to the VTA and the NAc appears to be involved in behavioral sensitization processes. However, dissociations regarding the role of the mPFC with respect to the development and expression of sensitization, as well as with respect to the psychostimulant being studied (amphetamine versus cocaine) appear to exist. The present study examined the role of the dorsal mPFC in the development and expression of 3,4-methylenedioxymethamphetamine (MDMA)-induced sensitization. Bilateral ibotenic acid or sham lesions of the dorsal mPFC were performed 7 days prior to or 4 days after a context-dependent sensitization-inducing regimen of MDMA (15 mg/kg i.p.) or saline. Rats were then challenged with MDMA (5 mg/kg i.p.) after 12 days of withdrawal. Ibotenic acid lesions did not affect the activating effects of MDMA, but prevented the development and expression of MDMA sensitization. Thus, the distance traveled during the development phase of sensitization increased in sham-lesioned rats but not in ibotenic-lesioned animals. Similarly, sham-lesioned rats showed a sensitized response when challenged with MDMA after the withdrawal period, an effect not observed in ibotenic-lesioned animals. These data reinforce the view that the dorsal mPFC is involved in psychostimulant sensitization and more specifically they indicate that the dorsal mPFC plays a key role in the development and expression of MDMA-induced behavioral sensitization. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/15863226/Ibotenic_acid_lesions_of_the_medial_prefrontal_cortex_block_the_development_and_expression_of_34_methylenedioxymethamphetamine_induced_behavioral_sensitization_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(04)00478-4 DB - PRIME DP - Unbound Medicine ER -