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Clozapine attenuates the locomotor sensitisation and the prepulse inhibition deficit induced by a repeated oral administration of Catha edulis extract and cathinone in rats.
Behav Brain Res. 2005 May 28; 160(2):365-73.BB

Abstract

Locomotor sensitisation and deficits in prepulse inhibition (PPI) induced by psychostimulants are two paradigms that have been widely studied as animal behavioural models of psychosis. Clozapine is one of the atypical antipsychotic agents which has been widely employed to reverse the aforementioned behavioural changes in these usual models. In this particular study, locomotor sensitisation and prepulse inhibition deficit were induced under the same context by intermittent oral administration of S-(-)-cathinone or Catha edulis extract in rats. The rats were then challenged by administration of the atypical antipsychotic drug, clozapine and were finally challenged with psychostimulants after 2-week of withdrawal. Locomotor activity and PPI were assessed and later analyses of the neurotransmitter levels were made. The results of this experiment show that repeated oral administration of cathinone or C. edulis extract enhanced locomotor and exploratory activity and lead to a gradual deficit in prepulse inhibition. This locomotor sensitisation and PPI deficit could be reversed by administration of clozapine. A challenge with psychostimulant on day 40 (i.e., after 2-week of withdrawal) resulted in a response similar to the initial exposure (day 1). Neurotransmitter level analyses showed a significant increase in the level of dopamine in the prefrontal cortex (p < 0.05). There was also a significant decrease in the level of 5-hydroxytryptamine (5-HT) in the nucleus accumbens (p < 0.05) and its metabolite, 5-hydroxyindole acetic acid (5-HIAA) in the prefrontal cortex (p < 0.01). In the remaining regions (anterior and posterior striatum), there were no significant changes. In conclusion, this is the first study to demonstrate that repeated administration of C. edulis extract, or commercial cathinone, induces prepulse inhibition deficit and clozapine reverses both C. edulis or cathinone-induced sensitised locomotion and prepulse inhibition deficit.

Authors+Show Affiliations

Department of Neuropharmacology, Zoological Institute, Faculty of Biology, University of Tuebingen, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

15863233

Citation

Banjaw, Mehret Yerdaw, et al. "Clozapine Attenuates the Locomotor Sensitisation and the Prepulse Inhibition Deficit Induced By a Repeated Oral Administration of Catha Edulis Extract and Cathinone in Rats." Behavioural Brain Research, vol. 160, no. 2, 2005, pp. 365-73.
Banjaw MY, Fendt M, Schmidt WJ. Clozapine attenuates the locomotor sensitisation and the prepulse inhibition deficit induced by a repeated oral administration of Catha edulis extract and cathinone in rats. Behav Brain Res. 2005;160(2):365-73.
Banjaw, M. Y., Fendt, M., & Schmidt, W. J. (2005). Clozapine attenuates the locomotor sensitisation and the prepulse inhibition deficit induced by a repeated oral administration of Catha edulis extract and cathinone in rats. Behavioural Brain Research, 160(2), 365-73.
Banjaw MY, Fendt M, Schmidt WJ. Clozapine Attenuates the Locomotor Sensitisation and the Prepulse Inhibition Deficit Induced By a Repeated Oral Administration of Catha Edulis Extract and Cathinone in Rats. Behav Brain Res. 2005 May 28;160(2):365-73. PubMed PMID: 15863233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clozapine attenuates the locomotor sensitisation and the prepulse inhibition deficit induced by a repeated oral administration of Catha edulis extract and cathinone in rats. AU - Banjaw,Mehret Yerdaw, AU - Fendt,Markus, AU - Schmidt,Werner J, Y1 - 2005/02/05/ PY - 2004/10/22/received PY - 2004/12/21/revised PY - 2005/01/10/accepted PY - 2005/5/3/pubmed PY - 2005/7/16/medline PY - 2005/5/3/entrez SP - 365 EP - 73 JF - Behavioural brain research JO - Behav. Brain Res. VL - 160 IS - 2 N2 - Locomotor sensitisation and deficits in prepulse inhibition (PPI) induced by psychostimulants are two paradigms that have been widely studied as animal behavioural models of psychosis. Clozapine is one of the atypical antipsychotic agents which has been widely employed to reverse the aforementioned behavioural changes in these usual models. In this particular study, locomotor sensitisation and prepulse inhibition deficit were induced under the same context by intermittent oral administration of S-(-)-cathinone or Catha edulis extract in rats. The rats were then challenged by administration of the atypical antipsychotic drug, clozapine and were finally challenged with psychostimulants after 2-week of withdrawal. Locomotor activity and PPI were assessed and later analyses of the neurotransmitter levels were made. The results of this experiment show that repeated oral administration of cathinone or C. edulis extract enhanced locomotor and exploratory activity and lead to a gradual deficit in prepulse inhibition. This locomotor sensitisation and PPI deficit could be reversed by administration of clozapine. A challenge with psychostimulant on day 40 (i.e., after 2-week of withdrawal) resulted in a response similar to the initial exposure (day 1). Neurotransmitter level analyses showed a significant increase in the level of dopamine in the prefrontal cortex (p < 0.05). There was also a significant decrease in the level of 5-hydroxytryptamine (5-HT) in the nucleus accumbens (p < 0.05) and its metabolite, 5-hydroxyindole acetic acid (5-HIAA) in the prefrontal cortex (p < 0.01). In the remaining regions (anterior and posterior striatum), there were no significant changes. In conclusion, this is the first study to demonstrate that repeated administration of C. edulis extract, or commercial cathinone, induces prepulse inhibition deficit and clozapine reverses both C. edulis or cathinone-induced sensitised locomotion and prepulse inhibition deficit. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/15863233/Clozapine_attenuates_the_locomotor_sensitisation_and_the_prepulse_inhibition_deficit_induced_by_a_repeated_oral_administration_of_Catha_edulis_extract_and_cathinone_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(05)00016-1 DB - PRIME DP - Unbound Medicine ER -