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Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial.
Age Ageing. 2005 May; 34(3):256-61.AA

Abstract

BACKGROUND

cranberry juice is often given to older people in hospital to prevent urinary tract infection (UTI), although there is little evidence to support its use.

OBJECTIVE

to assess whether cranberry juice ingestion is effective in reducing UTIs in older people in hospital.

DESIGN

randomised, placebo-controlled, double-blind trial.

SETTING

Medicine for the Elderly assessment and rehabilitation hospital wards.

SUBJECTS

376 older patients in hospital.

METHODS

participants were randomised to daily ingestion of 300 ml of cranberry juice or matching placebo beverage. The primary outcome was time to onset of first UTI. Secondary outcomes were adherence to beverage drinking, courses of antibiotics prescribed, and organisms responsible for UTIs.

RESULTS

a total of 21/376 (5.6%) participants developed a symptomatic UTI: 14/189 in the placebo group and 7/187 in the cranberry juice group. These between-group differences were not significant, relative risk (RR) 0.51 [95% CI 0.21-1.22, P = 0.122). Although there were significantly fewer infections with Escherichia coli in the cranberry group (13 versus 4) RR 0.31 [95% CI 0.10-0.94, P = 0.027], this should be interpreted with caution as it was a secondary outcome.

CONCLUSION

despite having the largest sample size of any clinical trial yet to have examined the effect of cranberry juice ingestion, the actual infection rate observed was lower than anticipated, making the study underpowered. This study has confirmed the acceptability of cranberry juice to older people. Larger trials are now required to determine whether it is effective in reducing UTIs in older hospital patients.

Authors+Show Affiliations

Section of Ageing and Health, Division of Medicine and Therapeutics, Department of Medical Microbiology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. m.e.t.mcmurdo@dundee.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15863410

Citation

McMurdo, Marion E T., et al. "Does Ingestion of Cranberry Juice Reduce Symptomatic Urinary Tract Infections in Older People in Hospital? a Double-blind, Placebo-controlled Trial." Age and Ageing, vol. 34, no. 3, 2005, pp. 256-61.
McMurdo ME, Bissett LY, Price RJ, et al. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing. 2005;34(3):256-61.
McMurdo, M. E., Bissett, L. Y., Price, R. J., Phillips, G., & Crombie, I. K. (2005). Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age and Ageing, 34(3), 256-61.
McMurdo ME, et al. Does Ingestion of Cranberry Juice Reduce Symptomatic Urinary Tract Infections in Older People in Hospital? a Double-blind, Placebo-controlled Trial. Age Ageing. 2005;34(3):256-61. PubMed PMID: 15863410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. AU - McMurdo,Marion E T, AU - Bissett,Linda Y, AU - Price,Rosemary J G, AU - Phillips,Gabby, AU - Crombie,Iain K, PY - 2005/5/3/pubmed PY - 2005/9/15/medline PY - 2005/5/3/entrez SP - 256 EP - 61 JF - Age and ageing JO - Age Ageing VL - 34 IS - 3 N2 - BACKGROUND: cranberry juice is often given to older people in hospital to prevent urinary tract infection (UTI), although there is little evidence to support its use. OBJECTIVE: to assess whether cranberry juice ingestion is effective in reducing UTIs in older people in hospital. DESIGN: randomised, placebo-controlled, double-blind trial. SETTING: Medicine for the Elderly assessment and rehabilitation hospital wards. SUBJECTS: 376 older patients in hospital. METHODS: participants were randomised to daily ingestion of 300 ml of cranberry juice or matching placebo beverage. The primary outcome was time to onset of first UTI. Secondary outcomes were adherence to beverage drinking, courses of antibiotics prescribed, and organisms responsible for UTIs. RESULTS: a total of 21/376 (5.6%) participants developed a symptomatic UTI: 14/189 in the placebo group and 7/187 in the cranberry juice group. These between-group differences were not significant, relative risk (RR) 0.51 [95% CI 0.21-1.22, P = 0.122). Although there were significantly fewer infections with Escherichia coli in the cranberry group (13 versus 4) RR 0.31 [95% CI 0.10-0.94, P = 0.027], this should be interpreted with caution as it was a secondary outcome. CONCLUSION: despite having the largest sample size of any clinical trial yet to have examined the effect of cranberry juice ingestion, the actual infection rate observed was lower than anticipated, making the study underpowered. This study has confirmed the acceptability of cranberry juice to older people. Larger trials are now required to determine whether it is effective in reducing UTIs in older hospital patients. SN - 0002-0729 UR - https://www.unboundmedicine.com/medline/citation/15863410/Does_ingestion_of_cranberry_juice_reduce_symptomatic_urinary_tract_infections_in_older_people_in_hospital_A_double_blind_placebo_controlled_trial_ L2 - https://academic.oup.com/ageing/article-lookup/doi/10.1093/ageing/afi101 DB - PRIME DP - Unbound Medicine ER -