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Omega-3 fatty acids and neuropsychiatric disorders.
Reprod Nutr Dev 2005 Jan-Feb; 45(1):1-28RN

Abstract

Epidemiological evidence suggests that dietary consumption of the long chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), commonly found in fish or fish oil, may modify the risk for certain neuropsychiatric disorders. As evidence, decreased blood levels of omega-3 fatty acids have been associated with several neuropsychiatric conditions, including Attention Deficit (Hyperactivity) Disorder, Alzheimer's Disease, Schizophrenia and Depression. Supplementation studies, using individual or combination omega-3 fatty acids, suggest the possibility for decreased symptoms associated with some of these conditions. Thus far, however, the benefits of supplementation, in terms of decreasing disease risk and/or aiding in symptom management, are not clear and more research is needed. The reasons for blood fatty acid alterations in these disorders are not known, nor are the potential mechanisms by which omega-3 fatty acids may function in normal neuronal activity and neuropsychiatric disease prevention and/or treatment. It is clear, however, that DHA is the predominant n-3 fatty acid found in the brain and that EPA plays an important role as an anti-inflammatory precursor. Both DHA and EPA can be linked with many aspects of neural function, including neurotransmission, membrane fluidity, ion channel and enzyme regulation and gene expression. This review summarizes the knowledge in terms of dietary omega-3 fatty acid intake and metabolism, as well as evidence pointing to potential mechanisms of omega-3 fatty acids in normal brain functioning, development of neuropsychiatric disorders and efficacy of omega-3 fatty acid supplementation in terms of symptom management.

Authors+Show Affiliations

Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15865053

Citation

Young, Genevieve, and Julie Conquer. "Omega-3 Fatty Acids and Neuropsychiatric Disorders." Reproduction, Nutrition, Development, vol. 45, no. 1, 2005, pp. 1-28.
Young G, Conquer J. Omega-3 fatty acids and neuropsychiatric disorders. Reprod Nutr Dev. 2005;45(1):1-28.
Young, G., & Conquer, J. (2005). Omega-3 fatty acids and neuropsychiatric disorders. Reproduction, Nutrition, Development, 45(1), pp. 1-28.
Young G, Conquer J. Omega-3 Fatty Acids and Neuropsychiatric Disorders. Reprod Nutr Dev. 2005;45(1):1-28. PubMed PMID: 15865053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acids and neuropsychiatric disorders. AU - Young,Genevieve, AU - Conquer,Julie, PY - 2005/5/4/pubmed PY - 2005/7/26/medline PY - 2005/5/4/entrez SP - 1 EP - 28 JF - Reproduction, nutrition, development JO - Reprod. Nutr. Dev. VL - 45 IS - 1 N2 - Epidemiological evidence suggests that dietary consumption of the long chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), commonly found in fish or fish oil, may modify the risk for certain neuropsychiatric disorders. As evidence, decreased blood levels of omega-3 fatty acids have been associated with several neuropsychiatric conditions, including Attention Deficit (Hyperactivity) Disorder, Alzheimer's Disease, Schizophrenia and Depression. Supplementation studies, using individual or combination omega-3 fatty acids, suggest the possibility for decreased symptoms associated with some of these conditions. Thus far, however, the benefits of supplementation, in terms of decreasing disease risk and/or aiding in symptom management, are not clear and more research is needed. The reasons for blood fatty acid alterations in these disorders are not known, nor are the potential mechanisms by which omega-3 fatty acids may function in normal neuronal activity and neuropsychiatric disease prevention and/or treatment. It is clear, however, that DHA is the predominant n-3 fatty acid found in the brain and that EPA plays an important role as an anti-inflammatory precursor. Both DHA and EPA can be linked with many aspects of neural function, including neurotransmission, membrane fluidity, ion channel and enzyme regulation and gene expression. This review summarizes the knowledge in terms of dietary omega-3 fatty acid intake and metabolism, as well as evidence pointing to potential mechanisms of omega-3 fatty acids in normal brain functioning, development of neuropsychiatric disorders and efficacy of omega-3 fatty acid supplementation in terms of symptom management. SN - 0926-5287 UR - https://www.unboundmedicine.com/medline/citation/15865053/Omega_3_fatty_acids_and_neuropsychiatric_disorders_ L2 - https://medlineplus.gov/childmentalhealth.html DB - PRIME DP - Unbound Medicine ER -