Tags

Type your tag names separated by a space and hit enter

Two residues in the hemagglutinin of A/Fujian/411/02-like influenza viruses are responsible for antigenic drift from A/Panama/2007/99.
Virology. 2005 May 25; 336(1):113-9.V

Abstract

The H3N2 vaccine strain (A/Panama/2007/99) for the 2003-2004 influenza season did not antigenically match the circulating A/Fujian/411/02-like H3N2 viruses and had reduced effectiveness against influenza outbreaks. A/Wyoming/03/2003, an A/Fujian-like virus, was recommended as the vaccine strain for the 2004-2005 season. A/Wyoming differed from A/Panama by 16 amino acids in the HA1 molecule. Reverse genetics was used to determine the minimal amino acid changes that were responsible for the antigenic drift from A/Panama to A/Wyoming. After substitutions of 2 of the 16 amino acids in the HA (H155T, Q156H), the A/Panama HA variant was antigenically equivalent to A/Wyoming as determined by hemagglutination inhibition and microneutralization assays using ferret postinfection antisera. Conversely, A/Wyoming containing the His-155 and Gln-156 residues from A/Panama was antigenically equivalent to A/Panama. These results indicated that only these two HA residues specified the antigenic drift from A/Panama to A/Wyoming; other amino acid differences between these two H3N2 viruses had minimal impact on virus antigenicity but impacted virus replication efficiency in eggs.

Authors+Show Affiliations

MedImmune Vaccines, Inc., 297 North Bernardo Avenue, Mountain View, CA 94043, USA. jinh@medimmune.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15866076

Citation

Jin, Hong, et al. "Two Residues in the Hemagglutinin of A/Fujian/411/02-like Influenza Viruses Are Responsible for Antigenic Drift From A/Panama/2007/99." Virology, vol. 336, no. 1, 2005, pp. 113-9.
Jin H, Zhou H, Liu H, et al. Two residues in the hemagglutinin of A/Fujian/411/02-like influenza viruses are responsible for antigenic drift from A/Panama/2007/99. Virology. 2005;336(1):113-9.
Jin, H., Zhou, H., Liu, H., Chan, W., Adhikary, L., Mahmood, K., Lee, M. S., & Kemble, G. (2005). Two residues in the hemagglutinin of A/Fujian/411/02-like influenza viruses are responsible for antigenic drift from A/Panama/2007/99. Virology, 336(1), 113-9.
Jin H, et al. Two Residues in the Hemagglutinin of A/Fujian/411/02-like Influenza Viruses Are Responsible for Antigenic Drift From A/Panama/2007/99. Virology. 2005 May 25;336(1):113-9. PubMed PMID: 15866076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two residues in the hemagglutinin of A/Fujian/411/02-like influenza viruses are responsible for antigenic drift from A/Panama/2007/99. AU - Jin,Hong, AU - Zhou,Helen, AU - Liu,Hui, AU - Chan,Winnie, AU - Adhikary,Lopa, AU - Mahmood,Kutubuddin, AU - Lee,Min-Shi, AU - Kemble,George, PY - 2005/01/19/received PY - 2005/03/04/revised PY - 2005/03/10/accepted PY - 2005/5/4/pubmed PY - 2005/7/1/medline PY - 2005/5/4/entrez SP - 113 EP - 9 JF - Virology JO - Virology VL - 336 IS - 1 N2 - The H3N2 vaccine strain (A/Panama/2007/99) for the 2003-2004 influenza season did not antigenically match the circulating A/Fujian/411/02-like H3N2 viruses and had reduced effectiveness against influenza outbreaks. A/Wyoming/03/2003, an A/Fujian-like virus, was recommended as the vaccine strain for the 2004-2005 season. A/Wyoming differed from A/Panama by 16 amino acids in the HA1 molecule. Reverse genetics was used to determine the minimal amino acid changes that were responsible for the antigenic drift from A/Panama to A/Wyoming. After substitutions of 2 of the 16 amino acids in the HA (H155T, Q156H), the A/Panama HA variant was antigenically equivalent to A/Wyoming as determined by hemagglutination inhibition and microneutralization assays using ferret postinfection antisera. Conversely, A/Wyoming containing the His-155 and Gln-156 residues from A/Panama was antigenically equivalent to A/Panama. These results indicated that only these two HA residues specified the antigenic drift from A/Panama to A/Wyoming; other amino acid differences between these two H3N2 viruses had minimal impact on virus antigenicity but impacted virus replication efficiency in eggs. SN - 0042-6822 UR - https://www.unboundmedicine.com/medline/citation/15866076/Two_residues_in_the_hemagglutinin_of_A/Fujian/411/02_like_influenza_viruses_are_responsible_for_antigenic_drift_from_A/Panama/2007/99_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(05)00155-8 DB - PRIME DP - Unbound Medicine ER -