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Overweight and obesity as risk factors for atrial fibrillation or flutter: the Danish Diet, Cancer, and Health Study.
Am J Med. 2005 May; 118(5):489-95.AJ

Abstract

PURPOSE

We examined the association between the body mass index analyzed as a continuous variable and by categorization according to World Health Organization criteria (normal weight, overweight and obesity) and the risk of a hospital (inpatient as well as outpatient) diagnosis of atrial fibrillation or flutter.

METHODS

Population-based prospective cohort study conducted from December 1993 to December 2001 among 47589 participants (22482 men and 25107 women) without preexisting cardiovascular or endocrine disease and with a mean age at baseline of 56 years (range 50-64 years) in the Danish Diet, Cancer, and Health Study. Subjects were followed up in the Danish National Registry of Patients and in the Danish Civil Registration System.

RESULTS

During follow-up (mean, 5.7 years) atrial fibrillation or flutter developed in 553 subjects (372 men and 181 women). The adjusted hazard ratio for atrial fibrillation or flutter per unit of increase in the body mass index was 1.08 (95% confidence interval [CI]: 1.05 to 1.11) in men and 1.06 (95% CI: 1.03 to 1.09) in women. When using normal weight as a reference, the adjusted hazard ratio for atrial fibrillation or flutter by overweight was 1.75 (95% CI: 1.35 to 2.27) in men and 1.39 (95% CI: 0.99 to 1.94) in women. The adjusted hazard ratio by obesity was 2.35 (95% CI: 1.70 to 3.25) in men and 1.99 (95% CI: 1.31 to 3.02) in women.

CONCLUSION

Overweight and obesity are associated with an increased risk of a diagnosis of atrial fibrillation or flutter.

Authors+Show Affiliations

Department of Cardiology, Aarhus University Hospital, DK 8000 Aarhus C, Denmark. lars.frost@as.aaa.dkNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15866251

Citation

Frost, Lars, et al. "Overweight and Obesity as Risk Factors for Atrial Fibrillation or Flutter: the Danish Diet, Cancer, and Health Study." The American Journal of Medicine, vol. 118, no. 5, 2005, pp. 489-95.
Frost L, Hune LJ, Vestergaard P. Overweight and obesity as risk factors for atrial fibrillation or flutter: the Danish Diet, Cancer, and Health Study. Am J Med. 2005;118(5):489-95.
Frost, L., Hune, L. J., & Vestergaard, P. (2005). Overweight and obesity as risk factors for atrial fibrillation or flutter: the Danish Diet, Cancer, and Health Study. The American Journal of Medicine, 118(5), 489-95.
Frost L, Hune LJ, Vestergaard P. Overweight and Obesity as Risk Factors for Atrial Fibrillation or Flutter: the Danish Diet, Cancer, and Health Study. Am J Med. 2005;118(5):489-95. PubMed PMID: 15866251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overweight and obesity as risk factors for atrial fibrillation or flutter: the Danish Diet, Cancer, and Health Study. AU - Frost,Lars, AU - Hune,Lone Juul, AU - Vestergaard,Peter, PY - 2004/09/13/received PY - 2005/5/4/pubmed PY - 2005/5/28/medline PY - 2005/5/4/entrez SP - 489 EP - 95 JF - The American journal of medicine JO - Am J Med VL - 118 IS - 5 N2 - PURPOSE: We examined the association between the body mass index analyzed as a continuous variable and by categorization according to World Health Organization criteria (normal weight, overweight and obesity) and the risk of a hospital (inpatient as well as outpatient) diagnosis of atrial fibrillation or flutter. METHODS: Population-based prospective cohort study conducted from December 1993 to December 2001 among 47589 participants (22482 men and 25107 women) without preexisting cardiovascular or endocrine disease and with a mean age at baseline of 56 years (range 50-64 years) in the Danish Diet, Cancer, and Health Study. Subjects were followed up in the Danish National Registry of Patients and in the Danish Civil Registration System. RESULTS: During follow-up (mean, 5.7 years) atrial fibrillation or flutter developed in 553 subjects (372 men and 181 women). The adjusted hazard ratio for atrial fibrillation or flutter per unit of increase in the body mass index was 1.08 (95% confidence interval [CI]: 1.05 to 1.11) in men and 1.06 (95% CI: 1.03 to 1.09) in women. When using normal weight as a reference, the adjusted hazard ratio for atrial fibrillation or flutter by overweight was 1.75 (95% CI: 1.35 to 2.27) in men and 1.39 (95% CI: 0.99 to 1.94) in women. The adjusted hazard ratio by obesity was 2.35 (95% CI: 1.70 to 3.25) in men and 1.99 (95% CI: 1.31 to 3.02) in women. CONCLUSION: Overweight and obesity are associated with an increased risk of a diagnosis of atrial fibrillation or flutter. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/15866251/Overweight_and_obesity_as_risk_factors_for_atrial_fibrillation_or_flutter:_the_Danish_Diet_Cancer_and_Health_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(05)00074-4 DB - PRIME DP - Unbound Medicine ER -