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Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment.
Fertil Steril. 2005 May; 83(5):1454-60.FS

Abstract

OBJECTIVE

To determine the prevalence of insulin resistance (IR) in a large population of patients with the polycystic ovary syndrome (PCOS).

DESIGN

Prospective, case-control.

SETTING

University medical center.

PATIENT(S)

Two hundred seventy-one PCOS patients and 260 eumenorrheic, non-hirsute, control women.

INTERVENTION(S)

History and physical examination and blood sampling.

MAIN OUTCOME MEASURE(S)

Total T, free T, DHEAS, sex hormone-binding globulin, and fasting glucose and insulin levels; homeostatic model assessment values for IR (HOMA-IR) and percent beta-cell function (HOMA-%beta-cell).

RESULT(S)

Patients with PCOS and controls differed significantly in all parameters studied, except fasting glucose. Because the HOMA-IR and HOMA-%beta-cell values were variably associated with race, age, and body mass index, the HOMA-IR and HOMA-%beta-cell values were then adjusted for these cofounders. After adjustment, 64.4% of PCOS patients were noted to be insulin resistant, and 2.6% had beta-cell dysfunction. Compared with PCOS patients without IR (n = 96), patients with IR (n = 174) were more obese and had higher beta-cell function.

CONCLUSION(S)

In patients with PCOS, the prevalence of IR was 64% according to the HOMA-IR measurement, after adjustment. Patients with IR were more clinically affected. Although IR is a common abnormality in PCOS, it does not seem to be a universal feature.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15866584

Citation

DeUgarte, Catherine Marin, et al. "Prevalence of Insulin Resistance in the Polycystic Ovary Syndrome Using the Homeostasis Model Assessment." Fertility and Sterility, vol. 83, no. 5, 2005, pp. 1454-60.
DeUgarte CM, Bartolucci AA, Azziz R. Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. Fertil Steril. 2005;83(5):1454-60.
DeUgarte, C. M., Bartolucci, A. A., & Azziz, R. (2005). Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. Fertility and Sterility, 83(5), 1454-60.
DeUgarte CM, Bartolucci AA, Azziz R. Prevalence of Insulin Resistance in the Polycystic Ovary Syndrome Using the Homeostasis Model Assessment. Fertil Steril. 2005;83(5):1454-60. PubMed PMID: 15866584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. AU - DeUgarte,Catherine Marin, AU - Bartolucci,Alfred A, AU - Azziz,Ricardo, PY - 2004/07/28/received PY - 2004/11/24/revised PY - 2004/11/24/accepted PY - 2005/5/4/pubmed PY - 2005/12/28/medline PY - 2005/5/4/entrez SP - 1454 EP - 60 JF - Fertility and sterility JO - Fertil. Steril. VL - 83 IS - 5 N2 - OBJECTIVE: To determine the prevalence of insulin resistance (IR) in a large population of patients with the polycystic ovary syndrome (PCOS). DESIGN: Prospective, case-control. SETTING: University medical center. PATIENT(S): Two hundred seventy-one PCOS patients and 260 eumenorrheic, non-hirsute, control women. INTERVENTION(S): History and physical examination and blood sampling. MAIN OUTCOME MEASURE(S): Total T, free T, DHEAS, sex hormone-binding globulin, and fasting glucose and insulin levels; homeostatic model assessment values for IR (HOMA-IR) and percent beta-cell function (HOMA-%beta-cell). RESULT(S): Patients with PCOS and controls differed significantly in all parameters studied, except fasting glucose. Because the HOMA-IR and HOMA-%beta-cell values were variably associated with race, age, and body mass index, the HOMA-IR and HOMA-%beta-cell values were then adjusted for these cofounders. After adjustment, 64.4% of PCOS patients were noted to be insulin resistant, and 2.6% had beta-cell dysfunction. Compared with PCOS patients without IR (n = 96), patients with IR (n = 174) were more obese and had higher beta-cell function. CONCLUSION(S): In patients with PCOS, the prevalence of IR was 64% according to the HOMA-IR measurement, after adjustment. Patients with IR were more clinically affected. Although IR is a common abnormality in PCOS, it does not seem to be a universal feature. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/15866584/Prevalence_of_insulin_resistance_in_the_polycystic_ovary_syndrome_using_the_homeostasis_model_assessment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(05)00373-0 DB - PRIME DP - Unbound Medicine ER -