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Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia.
Blood. 1992 Jun 01; 79(11):3067-70.Blood

Abstract

Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL) has a poor prognosis when treated with conventional chemotherapy. We analyzed the outcome of 67 HLA-identical sibling bone marrow transplants (BMTs) for Ph1-positive ALL reported to the International Bone Marrow Transplant Registry (IBMTR). Twenty-one of 67 (31%) transplant recipients survived in continuous complete remission more than 2 years after transplant. Two-year actuarial probabilities (95% confidence interval) of leukemia-free survival were 38% (23% to 55%) for 33 patients transplanted in first remission, 41% (23% to 61%) for 22 patients transplanted after relapse, and 25% (9% to 53%) for 12 patients failing to achieve remission with conventional chemotherapy. These data indicate that transplants are effective treatment for Ph1-positive ALL.

Authors+Show Affiliations

Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1586748

Citation

Barrett, A J., et al. "Bone Marrow Transplantation for Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia." Blood, vol. 79, no. 11, 1992, pp. 3067-70.
Barrett AJ, Horowitz MM, Ash RC, et al. Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood. 1992;79(11):3067-70.
Barrett, A. J., Horowitz, M. M., Ash, R. C., Atkinson, K., Gale, R. P., Goldman, J. M., Henslee-Downey, P. J., Herzig, R. H., Speck, B., & Zwaan, F. E. (1992). Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood, 79(11), 3067-70.
Barrett AJ, et al. Bone Marrow Transplantation for Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia. Blood. 1992 Jun 1;79(11):3067-70. PubMed PMID: 1586748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. A1 - Barrett,A J, AU - Horowitz,M M, AU - Ash,R C, AU - Atkinson,K, AU - Gale,R P, AU - Goldman,J M, AU - Henslee-Downey,P J, AU - Herzig,R H, AU - Speck,B, AU - Zwaan,F E, PY - 1992/6/1/pubmed PY - 1992/6/1/medline PY - 1992/6/1/entrez SP - 3067 EP - 70 JF - Blood JO - Blood VL - 79 IS - 11 N2 - Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL) has a poor prognosis when treated with conventional chemotherapy. We analyzed the outcome of 67 HLA-identical sibling bone marrow transplants (BMTs) for Ph1-positive ALL reported to the International Bone Marrow Transplant Registry (IBMTR). Twenty-one of 67 (31%) transplant recipients survived in continuous complete remission more than 2 years after transplant. Two-year actuarial probabilities (95% confidence interval) of leukemia-free survival were 38% (23% to 55%) for 33 patients transplanted in first remission, 41% (23% to 61%) for 22 patients transplanted after relapse, and 25% (9% to 53%) for 12 patients failing to achieve remission with conventional chemotherapy. These data indicate that transplants are effective treatment for Ph1-positive ALL. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/1586748/Bone_marrow_transplantation_for_Philadelphia_chromosome_positive_acute_lymphoblastic_leukemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-4971(20)71242-5 DB - PRIME DP - Unbound Medicine ER -