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Obesity, smooth muscle, and airway hyperresponsiveness.
J Allergy Clin Immunol 2005; 115(5):925-7JA

Abstract

Both asthma and obesity are large and growing public health issues. Mounting evidence now implicates obesity as a major risk factor for asthma, thus linking these 2 major epidemics. Moreover, both in human subjects and in mice, obesity appears to predispose toward airway hyperresponsiveness. This review describes potential mechanisms whereby obesity might modify airway smooth muscle function to explain these observations. These mechanisms include both static and dynamic mechanical factors attributable to decreases in functional residual capacity and decreases in tidal volume that are observed in the obese. They include also obesity-related changes in lung development, chronic systemic inflammation (including increased serum levels of inflammatory cytokines and chemokines), and adipocyte-derived factors, including leptin, adiponectin, and plasminogen activator inhibitor.

Authors+Show Affiliations

Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15867846

Citation

Shore, Stephanie A., and Jeffrey J. Fredberg. "Obesity, Smooth Muscle, and Airway Hyperresponsiveness." The Journal of Allergy and Clinical Immunology, vol. 115, no. 5, 2005, pp. 925-7.
Shore SA, Fredberg JJ. Obesity, smooth muscle, and airway hyperresponsiveness. J Allergy Clin Immunol. 2005;115(5):925-7.
Shore, S. A., & Fredberg, J. J. (2005). Obesity, smooth muscle, and airway hyperresponsiveness. The Journal of Allergy and Clinical Immunology, 115(5), pp. 925-7.
Shore SA, Fredberg JJ. Obesity, Smooth Muscle, and Airway Hyperresponsiveness. J Allergy Clin Immunol. 2005;115(5):925-7. PubMed PMID: 15867846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity, smooth muscle, and airway hyperresponsiveness. AU - Shore,Stephanie A, AU - Fredberg,Jeffrey J, PY - 2005/5/4/pubmed PY - 2005/6/23/medline PY - 2005/5/4/entrez SP - 925 EP - 7 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 115 IS - 5 N2 - Both asthma and obesity are large and growing public health issues. Mounting evidence now implicates obesity as a major risk factor for asthma, thus linking these 2 major epidemics. Moreover, both in human subjects and in mice, obesity appears to predispose toward airway hyperresponsiveness. This review describes potential mechanisms whereby obesity might modify airway smooth muscle function to explain these observations. These mechanisms include both static and dynamic mechanical factors attributable to decreases in functional residual capacity and decreases in tidal volume that are observed in the obese. They include also obesity-related changes in lung development, chronic systemic inflammation (including increased serum levels of inflammatory cytokines and chemokines), and adipocyte-derived factors, including leptin, adiponectin, and plasminogen activator inhibitor. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/15867846/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674905003258 DB - PRIME DP - Unbound Medicine ER -