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Obesity, smooth muscle, and airway hyperresponsiveness.

Abstract

Both asthma and obesity are large and growing public health issues. Mounting evidence now implicates obesity as a major risk factor for asthma, thus linking these 2 major epidemics. Moreover, both in human subjects and in mice, obesity appears to predispose toward airway hyperresponsiveness. This review describes potential mechanisms whereby obesity might modify airway smooth muscle function to explain these observations. These mechanisms include both static and dynamic mechanical factors attributable to decreases in functional residual capacity and decreases in tidal volume that are observed in the obese. They include also obesity-related changes in lung development, chronic systemic inflammation (including increased serum levels of inflammatory cytokines and chemokines), and adipocyte-derived factors, including leptin, adiponectin, and plasminogen activator inhibitor.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA.

    Source

    MeSH

    Adiponectin
    Animals
    Asthma
    Cytokines
    Functional Residual Capacity
    Humans
    Inflammation
    Intercellular Signaling Peptides and Proteins
    Leptin
    Muscle, Smooth
    Obesity
    Plasminogen Activators
    Respiratory System

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    15867846

    Citation

    Shore, Stephanie A., and Jeffrey J. Fredberg. "Obesity, Smooth Muscle, and Airway Hyperresponsiveness." The Journal of Allergy and Clinical Immunology, vol. 115, no. 5, 2005, pp. 925-7.
    Shore SA, Fredberg JJ. Obesity, smooth muscle, and airway hyperresponsiveness. J Allergy Clin Immunol. 2005;115(5):925-7.
    Shore, S. A., & Fredberg, J. J. (2005). Obesity, smooth muscle, and airway hyperresponsiveness. The Journal of Allergy and Clinical Immunology, 115(5), pp. 925-7.
    Shore SA, Fredberg JJ. Obesity, Smooth Muscle, and Airway Hyperresponsiveness. J Allergy Clin Immunol. 2005;115(5):925-7. PubMed PMID: 15867846.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Obesity, smooth muscle, and airway hyperresponsiveness. AU - Shore,Stephanie A, AU - Fredberg,Jeffrey J, PY - 2005/5/4/pubmed PY - 2005/6/23/medline PY - 2005/5/4/entrez SP - 925 EP - 7 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 115 IS - 5 N2 - Both asthma and obesity are large and growing public health issues. Mounting evidence now implicates obesity as a major risk factor for asthma, thus linking these 2 major epidemics. Moreover, both in human subjects and in mice, obesity appears to predispose toward airway hyperresponsiveness. This review describes potential mechanisms whereby obesity might modify airway smooth muscle function to explain these observations. These mechanisms include both static and dynamic mechanical factors attributable to decreases in functional residual capacity and decreases in tidal volume that are observed in the obese. They include also obesity-related changes in lung development, chronic systemic inflammation (including increased serum levels of inflammatory cytokines and chemokines), and adipocyte-derived factors, including leptin, adiponectin, and plasminogen activator inhibitor. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/15867846/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674905003258 DB - PRIME DP - Unbound Medicine ER -