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Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years.
J Allergy Clin Immunol 2005; 115(5):946-52JA

Abstract

BACKGROUND

The relationship between mite and pet allergen exposure in infancy and the subsequent development of sensitization and asthma is complex.

OBJECTIVE

We prospectively investigated the effect of allergen exposure at 3 months of age on the development of sensitization, wheeze, and physician-diagnosed asthma in the first 4 years of life in a birth cohort of children with and without an atopic mother.

METHODS

Children participated in the Prevention and Incidence of Asthma and Mite Allergy study. Allergen exposure at 3 months of age was determined from mattress dust samples. Specific IgE to inhalant allergens was measured at 4 years of age, and information about wheeze and physician-diagnosed asthma was collected with yearly questionnaires.

RESULTS

Mite and cat allergen exposure in infancy were associated with an increased risk of specific sensitization to house dust mite and cat, respectively, at 4 years of age. There were borderline significant associations between cat allergen exposure and persistent wheeze in the total study population and between dog allergen exposure and persistent wheeze in children with a nonatopic mother. In children with an atopic mother, there was some indication of a positive association between mite allergen exposure and physician-diagnosed asthma.

CONCLUSION

Early house dust mite and cat allergen exposure might lead to sensitization and, in case of cat allergen exposure, to persistent wheeze. Early mite and dog allergen exposure might lead to asthma and persistent wheeze, respectively, but only in subgroups defined by maternal atopy.

Authors+Show Affiliations

Center for Prevention and Health Services Research, National Institute for Public Health and Environment, Bilthoven, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15867850

Citation

Brussee, Jessica E., et al. "Allergen Exposure in Infancy and the Development of Sensitization, Wheeze, and Asthma at 4 Years." The Journal of Allergy and Clinical Immunology, vol. 115, no. 5, 2005, pp. 946-52.
Brussee JE, Smit HA, van Strien RT, et al. Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years. J Allergy Clin Immunol. 2005;115(5):946-52.
Brussee, J. E., Smit, H. A., van Strien, R. T., Corver, K., Kerkhof, M., Wijga, A. H., ... Brunekreef, B. (2005). Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years. The Journal of Allergy and Clinical Immunology, 115(5), pp. 946-52.
Brussee JE, et al. Allergen Exposure in Infancy and the Development of Sensitization, Wheeze, and Asthma at 4 Years. J Allergy Clin Immunol. 2005;115(5):946-52. PubMed PMID: 15867850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years. AU - Brussee,Jessica E, AU - Smit,Henriette A, AU - van Strien,Robert T, AU - Corver,Karen, AU - Kerkhof,Marjan, AU - Wijga,Alet H, AU - Aalberse,Rob C, AU - Postma,Dirkje, AU - Gerritsen,Jorrit, AU - Grobbee,Diederick E, AU - de Jongste,Johan C, AU - Brunekreef,Bert, PY - 2005/5/4/pubmed PY - 2005/6/23/medline PY - 2005/5/4/entrez SP - 946 EP - 52 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 115 IS - 5 N2 - BACKGROUND: The relationship between mite and pet allergen exposure in infancy and the subsequent development of sensitization and asthma is complex. OBJECTIVE: We prospectively investigated the effect of allergen exposure at 3 months of age on the development of sensitization, wheeze, and physician-diagnosed asthma in the first 4 years of life in a birth cohort of children with and without an atopic mother. METHODS: Children participated in the Prevention and Incidence of Asthma and Mite Allergy study. Allergen exposure at 3 months of age was determined from mattress dust samples. Specific IgE to inhalant allergens was measured at 4 years of age, and information about wheeze and physician-diagnosed asthma was collected with yearly questionnaires. RESULTS: Mite and cat allergen exposure in infancy were associated with an increased risk of specific sensitization to house dust mite and cat, respectively, at 4 years of age. There were borderline significant associations between cat allergen exposure and persistent wheeze in the total study population and between dog allergen exposure and persistent wheeze in children with a nonatopic mother. In children with an atopic mother, there was some indication of a positive association between mite allergen exposure and physician-diagnosed asthma. CONCLUSION: Early house dust mite and cat allergen exposure might lead to sensitization and, in case of cat allergen exposure, to persistent wheeze. Early mite and dog allergen exposure might lead to asthma and persistent wheeze, respectively, but only in subgroups defined by maternal atopy. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/15867850/Allergen_exposure_in_infancy_and_the_development_of_sensitization_wheeze_and_asthma_at_4_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674905005270 DB - PRIME DP - Unbound Medicine ER -